GlyConnect

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taxonomy (1) protein (13) source (7) structure (10) composition (1) disease (10) reference (19) site (20) peptide (13)

Taxonomy

Homo sapiens (Human)

Protein

Source

Reported structure

Composition

Hex:7 HexNAc:2 (avg mass : 1559.4021 )

Disease

Reference

Quantitative Longitudinal Inventory of the N-Glycoproteome of Human Milk from a Single Donor Reveals the Highly Variable Repertoire and Dynamic Site-Specific Changes (2020 - Jing Zhu, Yu-Hsien Lin, Kelly A Dingess, Marko Mank, Bernd Stahl, Albert J R Heck) / Status : Reviewed
A novel, ultrasensitive approach for quantitative carbohydrate composition and linkage analysis using LC-ESI ion trap tandem mass spectrometry (2019 - Kathirvel Alagesan, Daniel Varon Silva, Peter H Seeberger, Daniel Kolarich) / Status : Reviewed
Site-Specific Profiling of Serum Glycoproteins Using N-Linked Glycan and Glycosite Analysis Revealing Atypical N-Glycosylation Sites on Albumin and α-1B-Glycoprotein (2018 - Shisheng Sun, Yingwei Hu, Li Jia, Shadi Toghi Eshghi, Yang Liu, Punit Shah, Hui Zhang) / Status : Unreviewed
Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
A Microarray-Matrix-assisted Laser Desorption/Ionization-Mass Spectrometry Approach for Site-specific Protein N-glycosylation Analysis, as Demonstrated for Human Serum Immunoglobulin M (IgM) (2015 - Martin Pabst, Simon Karl Küster, Fabian Wahl, Jasmin Krismer, Petra S.Dittrich, Renato Zenobi) / Status : Reviewed
A Method for Comprehensive Glycosite-Mapping and Direct Quantitation of Serum Glycoproteins (2015 - Qiuting Hong, L. Renee Ruhaak, Carol Stroble, Evan Parker, Jincui Huang, Emanual Maverakis, Carlito B. Lebrilla) / Status : Reviewed
The serum immunoglobulin G glycosylation signature of gastric cancer (2015 - L. Renee Ruhaak, Donald A. Barkauskas, Javier Torres, Cara L. Cooke, Lauren D. Wu, Carol Stroble, Sureyya Ozcan, Cynthia C. Williams, Margarita Camorlinga, David M. Rocke, Carlito B. Lebrilla, Jay V. Solnick,) / Status : Reviewed
A single glycan on IgE is indispensable for initiation of anaphylaxis (2015 - Kai-Ting C. Shade, Barbara Platzer, Nathaniel Washburn, Vinidhra Mani, Yannic C. Bartsch, Michelle Conroy, Jose D. Pagan, Carlos Bosques, Thorsten R. Mempel, Edda Fiebiger, Robert M. Anthony) / Status : Reviewed
Expression and glycoengineering of functionally active heteromultimeric IgM in plants (2014 - Loos A, Gruber C, Altmann F, Mehofer U, Hensel F, Grandits M, Oostenbrink C, Stadlmayr G, Furtmüller PG, Steinkellner H) / Status : Reviewed
Efficient and accurate glycopeptide identification pipeline for high-throughput site-specific N-glycosylation analysis (2014 - Liu M, Zhang Y, Chen Y, Yan G, Shen C, Cao J, Zhou X, Liu X, Zhang L, Shen H, Lu H, He F, Yang P) / Status : Reviewed
Site-specific N-glycosylation analysis of human immunoglobulin E. (2014 - Plomp R, Hensbergen PJ, Rombouts Y, Zauner G, Dragan I, Koeleman CA, Deelder AM, Wuhrer M) / Status : Reviewed
Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels, (2014 - Atfa Sassi, Sandra Lazaroski, Gang Wu, Stuart M. Haslam, Manfred Fliegauf, Fethi Mellouli, Turkan Patiroglu, Ekrem Unal, Mehmet Akif Ozdemir, Zineb Jouhadi, Khadija Khadir, Leila Ben-Khemis, Meriem Ben-Ali, Imen Ben-Mustapha, Lamia Borchani, Dietmar Pfeifer, Thilo Jakob, Monia Khemiri, A. Charlotta Asplund, Manuela O. Gustafsson, Karin E. Lundin, Elin Falk-Sörqvist, Lotte N. Moens, Hatice Eke Gungor, Karin R. Engelhardt, Magdalena Dziadzio, Hans Stauss, Bernhard Fleckenstein, Rebecca Meier, Khairunnadiya Prayitno, Andrea Maul-Pavicic, Sandra Schaffer, Mirzokhid Rakhmanov, Philipp Henneke, Helene Kraus, Hermann Eibel, Uwe Kölsch, Sellama Nadifi, Mats Nilsson, Mohamed Bejaoui, Alejandro A. Schäffer, C.I. Edvard Smith, Anne Dell, Mohamed-Ridha Barbouche, Bodo Grimbacher) / Status : Reviewed
GlycoSpectrumScan: Fishing Glycopeptides from MS Spectra of Protease Digests of Human Colostrum sIgA (2010 - Nandan Deshpande, Pia H. Jensen, Nicolle H. Packer, Daniel Kolarich) / Status : Reviewed
Human Serum IgM Glycosylation: IDENTIFICATION OF GLYCOFORMS THAT CAN BIND TO MANNAN-BINDING LECTIN (2005 - James N.Arnold, Mark R.Wormald, David M.Suter, Catherine M.Radcliffe, David J.Harvey, Raymond A.Dwek, Pauline M.Rudd, Robert B.Sim) / Status : Reviewed
The Glycosylation of Human Serum IgD and IgE and the Accessibility of Identified Oligomannose Structures for Interaction with Mannan-Binding Lectin (2004 - James N. Arnold, Catherine M. Radcliffe, Mark R. Wormald, Louise Royle, David J. Harvey, Max Crispin, Raymond A. Dwek, Robert B. Sim and Pauline M. Rudd) / Status : Reviewed
Comparative study of the N-glycans of human monoclonal immunoglobulins M produced by hybridoma and parental cells. (2000 - Fukuta K, Abe R, Yokomatsu T, Kono N, Nagatomi Y, Asanagi M, Shimazaki Y, Makino T) / Status : Reviewed
Control of bisecting GlcNAc addition to N-linked sugar chains. (2000 - Fukuta K, Abe R, Yokomatsu T, Omae F, Asanagi M, Makino T) / Status : Reviewed
The conformational effects of N-glycosylation on the tailpiece from serum IgM. (1991 - Wormald M, Wooten E, Bazzo R, Edge C, Feinstein A, Rademacher T, Dwek R) / Status : Reviewed
Structures of the oligosaccharides present at the three asparagine-linked glycosylation sites of human IgD. (1983 - S J Mellis, J U Baenziger) / Status : Reviewed

Reported glycosite

Immunoglobulin alpha (non secretory) / Homo sapiens
- Asn-144
Immunoglobulin epsilon chain c region / Homo sapiens
- Undefined site
- Asn-275
Immunoglobulin gamma / Homo sapiens
- Undefined site
Immunoglobulin gamma-1 heavy chain / Homo sapiens
- Undefined site
Immunoglobulin heavy constant alpha 1 / Homo sapiens
- Asn-144
- Asn-340
Immunoglobulin heavy constant alpha 2 / Homo sapiens
- Asn-131
- Asn-205
Immunoglobulin heavy constant delta / Homo sapiens
- Undefined site
- Asn-225
Immunoglobulin heavy constant gamma 1 / Homo sapiens
- Asn-180
Immunoglobulin heavy constant gamma 2 / Homo sapiens
- Undefined site
Immunoglobulin heavy constant gamma 2 - heavy chain 1 / Homo sapiens
- Undefined site
Immunoglobulin heavy constant mu / Homo sapiens
- Undefined site
- Asn-209
- Asn-279
- Asn-440
Immunoglobulin J chain / Homo sapiens
- Asn-71
Immunoglobulin superfamily member 8 / Homo sapiens
- Asn-327

Mass spectrometry observed peptide

IIVPINNRENISDPTSPIR (19aa)
- P01591 Asn-71 Immunoglobulin J chain / Homo sapiens
RLSLHRPALEDLLLGSEANLTCTLTGLRD (29aa)
- P01876 Asn-144 Immunoglobulin heavy constant alpha 1 / Homo sapiens
LSLHRPALEDLLLGSEANLTCTLTGLR (27aa)
- P01877 Asn-144 Immunoglobulin alpha (non secretory) / Homo sapiens
- P01876 Asn-144 Immunoglobulin alpha (non secretory) / Homo sapiens
- P01877 Asn-131 Immunoglobulin heavy constant alpha 2 / Homo sapiens
- P01876 Asn-144 Immunoglobulin heavy constant alpha 1 / Homo sapiens
EEQYNSTYR (9aa)
- P01857 Asn-180 Immunoglobulin heavy constant gamma 1 / Homo sapiens
TPLTANITK (9aa)
- P01877 Asn-205 Immunoglobulin heavy constant alpha 2 / Homo sapiens
GITFQQNASSMCVPDQDTAIR (21aa)
- P01871 Asn-209 Immunoglobulin heavy constant mu / Homo sapiens
SHPNATFSAVGE (12aa)
- P01871 Asn-279 Immunoglobulin heavy constant mu / Homo sapiens
IGPGEPIEIICNVSGAIPPAGR (22aa)
- Q969P0 Asn-327 Immunoglobulin superfamily member 8 / Homo sapiens
IAGKPTHVNVSVVMAEVDGTCY (22aa)
- P01876 Asn-340 Immunoglobulin heavy constant alpha 1 / Homo sapiens
RLAGKPTHVNVSVVMAEVDGTCY- (24aa)
- P01876 Asn-340 Immunoglobulin heavy constant alpha 1 / Homo sapiens
STGKPTLYNVSLVMSDTAGTC (21aa)
- P01871 Asn-440 Immunoglobulin heavy constant mu / Homo sapiens
STGKPTLYNVSLV(MSO)SDTAGTCY (26aa)
- P01871 Asn-440 Immunoglobulin heavy constant mu / Homo sapiens
STGKPTLYNVSLVMSDTAGTCY (22aa)
- P01871 Asn-440 Immunoglobulin heavy constant mu / Homo sapiens

- N-Linked / High-Mannose (avg mass : 1559.4021)
- N-Linked / High-Mannose (avg mass : 1559.4021)
- N-Linked / High-Mannose (avg mass : 1559.4021)
- N-Linked / High-Mannose (avg mass : 1559.4021)
- N-Linked / High-Mannose (avg mass : 1559.4021)
- N-Linked / High-Mannose (avg mass : 1559.4021)
- N-Linked / High-Mannose (avg mass : 1559.4021)
- N-Linked / High-Mannose (avg mass : 1559.4021)
- N-Linked / High-Mannose (avg mass : 1559.4021)
- N-Linked / Undefined core (avg mass : 1559.4021)

- Hex:7 HexNAc:2 / N-Linked (avg mass : 1559.4021)