Blood Plasma

Taxonomy

• Homo sapiens (Human)

Protein

• A disintegrin and metalloproteinase with thrombospondin motifs (13adamts13) / Homo sapiens    Q76LX8
• Coagulation factor VII / Homo sapiens    P08709
• Immunoglobulin heavy constant alpha 1 / Homo sapiens    P01876

Source

• Blood Plasma (UBERON_0001969)  

Reported structure

• O-Linked / Core 0 / GalNAc
• O-Linked / O-Fuc / Fuc
• O-Linked / O-Glc / Glc

Composition

• dHex:1 (avg mass : 164.1583 )
• HexNAc:1 (avg mass : 221.2103 )
• Hex:1 (avg mass : 180.1577 )

Disease

• Control/Healthy
• Myeloma, Multiple (DOID:9538)

Reference

• Identification of N-linked glycosylation and putative O-fucosylation, C-mannosylation sites in plasma derived ADAMTS13 (2014 - Sorvillo N, Kaijen PH, Matsumoto M, Fujimura Y, van der Zwaan C, Verbij FC, Pos W, Fijnheer R, Voorberg J, Meijer AB) / Status : Reviewed
• Naturally Occurring Structural Isomers in Serum IgA1 O-Glycosylation (2012 - Kazuo Takahashi, Archer D. Smith, IV, Knud Poulsen, Mogens Kilian, Bruce A. Julian, Jiri Mestecky, Jan Novak, Matthew B. Renfrow) / Status : Reviewed
• Human plasma and recombinant factor VII. Characterization of O-glycosylations at serine residues 52 and 60 and effects of site-directed mutagenesis of serine 52 to alanine. (1991 - Bjoern S, Foster D, Thim L, Wiberg F, Christensen M, Komiyama Y, Pedersen A, Kisiel W) / Status : Reviewed

Reported glycosite

• A disintegrin and metalloproteinase with thrombospondin motifs (13adamts13) / Homo sapiens
  •        Ser-698
  •        Ser-907
  •        Ser-1087
• Coagulation factor VII / Homo sapiens
  •        Undefined site
  •        Ser-112
• Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •        Thr-106
  •        Thr-109
  •        Ser-111
  •        Ser-113
  •        Thr-114
  •        Thr-117

Mass spectrometry observed peptide

• HYTNPSQDVTVPCPVPSTPPTPSP (24aa)
  •    P01876    Ser-111     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Ser-113     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Thr-109     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Thr-106     Immunoglobulin heavy constant alpha 1 / Homo sapiens
• STPPTPSPSCCHPR (14aa)
  •    P01876    Thr-117     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Thr-114     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Ser-113     Immunoglobulin heavy constant alpha 1 / Homo sapiens