Colon

Taxonomy

• Homo sapiens (Human)

Protein

• Keratin, type i cytoskeletal 18 / Homo sapiens    P05783
• Keratin, type II cytoskeletal 8 / Homo sapiens    P05787
• Unspecified mucin / Homo sapiens    

Source

• Colon (UBERON_0001155)   HT-29 (CVCL_0320)  
• Colon (UBERON_0001155)   LS174T (CVCL_1384)  

Reported structure

• O-Linked / Core 0 / GalNAc
• O-Linked / O-GlcNAc / GlcNAc(b

Composition

• HexNAc:1 (avg mass : 221.2103 )

Disease

• Adenocarcinoma (DOID:299)
• Adenocarcinoma, Grade II (DOID:299)

Reference

• Neutralization of pH in the Golgi apparatus causes redistribution of glycosyltransferases and changes in the O-glycosylation of mucins. (2001 - Axelsson M, Karlsson N, Steel D, Ouwendijk J, Nilsson T, Hansson G) / Status : Reviewed
• Identification and mutational analysis of the glycosylation sites of human keratin 18. (1995 - Ku N, Omary M) / Status : Reviewed
• Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18. (1991 - Chou C, Smith A, Omary M) / Status : Reviewed

Reported glycosite

• Keratin, type i cytoskeletal 18 / Homo sapiens
  •        Ser-30
  •        Ser-49
• Keratin, type II cytoskeletal 8 / Homo sapiens
  •        Undefined site
• Unspecified mucin / Homo sapiens
  •        Undefined site

Mass spectrometry observed peptide