Structure

Taxonomy

• Homo sapiens (Human)

Protein

• Immunoglobulin heavy constant alpha 1 / Homo sapiens    P01876

Source

• Blood Plasma (UBERON_0001969)  
• Blood Serum (UBERON_0001977)  

Reported structure

• O-Linked / Core 0 / GalNAc

Composition

• HexNAc:1 (avg mass : 221.2103 )

Disease

• Control/Healthy
• Myeloma, Multiple (DOID:9538)

Reference

• Naturally Occurring Structural Isomers in Serum IgA1 O-Glycosylation (2012 - Kazuo Takahashi, Archer D. Smith, IV, Knud Poulsen, Mogens Kilian, Bruce A. Julian, Jiri Mestecky, Jan Novak, Matthew B. Renfrow) / Status : Reviewed
• O-linked oligosaccharides from human serum immunoglobulin A1. (1989 - Field M, Dwek R, Edge C, Rademacher T) / Status : Reviewed
• Structure of the carbohydrate units of IgA1 immunoglobulin. II. Stucture of the O-glycosidically linked oligosaccharide units. (1974 - Baenziger J, Kornfeld S) / Status : Reviewed

Reported glycosite

• Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •        Undefined site
  •        Ser-105
  •        Thr-106
  •        Thr-109
  •        Ser-111
  •        Ser-113
  •        Thr-114
  •        Thr-117

Mass spectrometry observed peptide

• HYTNPSQDVTVPCPVPSTPPTPSP (24aa)
  •    P01876    Ser-111     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Ser-113     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Thr-109     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Thr-106     Immunoglobulin heavy constant alpha 1 / Homo sapiens
• STPPTPSPSCCHPR (14aa)
  •    P01876    Ser-113     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Thr-117     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Thr-114     Immunoglobulin heavy constant alpha 1 / Homo sapiens

GalNAc

RES
1b:a-dgal-HEX-1:5
2s:n-acetyl
LIN
1:1d(2+1)2n