GlyConnect

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taxonomy (1) protein (18) source (5) structure (1) composition (1) disease (4) reference (10) site (25) peptide (10)

Taxonomy

Homo sapiens (Human)

Protein

Source

Reported structure

N-Linked / High-Mannose / Man(a1-3)[Man(a1-6)]Man(a1-6)[Man(a1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

Hex:6 HexNAc:2 (avg mass : 1397.2597 )

Disease

Reference

Quantitative Longitudinal Inventory of the N-Glycoproteome of Human Milk from a Single Donor Reveals the Highly Variable Repertoire and Dynamic Site-Specific Changes (2020 - Jing Zhu, Yu-Hsien Lin, Kelly A Dingess, Marko Mank, Bernd Stahl, Albert J R Heck) / Status : Reviewed
A novel, ultrasensitive approach for quantitative carbohydrate composition and linkage analysis using LC-ESI ion trap tandem mass spectrometry (2019 - Kathirvel Alagesan, Daniel Varon Silva, Peter H Seeberger, Daniel Kolarich) / Status : Reviewed
A Microarray-Matrix-assisted Laser Desorption/Ionization-Mass Spectrometry Approach for Site-specific Protein N-glycosylation Analysis, as Demonstrated for Human Serum Immunoglobulin M (IgM) (2015 - Martin Pabst, Simon Karl Küster, Fabian Wahl, Jasmin Krismer, Petra S.Dittrich, Renato Zenobi) / Status : Reviewed
A Method for Comprehensive Glycosite-Mapping and Direct Quantitation of Serum Glycoproteins (2015 - Qiuting Hong, L. Renee Ruhaak, Carol Stroble, Evan Parker, Jincui Huang, Emanual Maverakis, Carlito B. Lebrilla) / Status : Reviewed
GlycoSpectrumScan: Fishing Glycopeptides from MS Spectra of Protease Digests of Human Colostrum sIgA (2010 - Nandan Deshpande, Pia H. Jensen, Nicolle H. Packer, Daniel Kolarich) / Status : Reviewed
Human Serum IgM Glycosylation: IDENTIFICATION OF GLYCOFORMS THAT CAN BIND TO MANNAN-BINDING LECTIN (2005 - James N.Arnold, Mark R.Wormald, David M.Suter, Catherine M.Radcliffe, David J.Harvey, Raymond A.Dwek, Pauline M.Rudd, Robert B.Sim) / Status : Reviewed
The Glycosylation of Human Serum IgD and IgE and the Accessibility of Identified Oligomannose Structures for Interaction with Mannan-Binding Lectin (2004 - James N. Arnold, Catherine M. Radcliffe, Mark R. Wormald, Louise Royle, David J. Harvey, Max Crispin, Raymond A. Dwek, Robert B. Sim and Pauline M. Rudd) / Status : Reviewed
Multiple interactions of IgG with its core oligosaccharide can modulate recognition by complement and human Fc gamma recpetor I and influence the synthesis of its oligosaccharide chains (1996 - Lund, Takahashi, Pound, Goodall, Jefferis) / Status : Reviewed
The conformational effects of N-glycosylation on the tailpiece from serum IgM. (1991 - Wormald M, Wooten E, Bazzo R, Edge C, Feinstein A, Rademacher T, Dwek R) / Status : Reviewed
Structures of the oligosaccharides present at the three asparagine-linked glycosylation sites of human IgD. (1983 - S J Mellis, J U Baenziger) / Status : Reviewed

Reported glycosite

Immunoglobulin alpha (non secretory) / Homo sapiens
- Asn-144
Immunoglobulin alpha-2 heavy chain (secretory) - heavy chain 2 / Homo sapiens
- Undefined site
Immunoglobulin alpha-2 heavy chain (secretory) - heavy chain 3 / Homo sapiens
- Undefined site
Immunoglobulin epsilon chain c region / Homo sapiens
- Undefined site
Immunoglobulin gamma-3 (anti-nip antibody) / Homo sapiens
- Undefined site
Immunoglobulin gamma-3-[da265] (anti-nip antibody) / Homo sapiens
- Undefined site
Immunoglobulin gamma-3-[fa241] (anti-nip antibody) / Homo sapiens
- Undefined site
Immunoglobulin gamma-3-[fa243] (anti-nip antibody) / Homo sapiens
- Undefined site
Immunoglobulin gamma-3-[ra301] (anti-nip antibody) / Homo sapiens
- Undefined site
Immunoglobulin gamma-3-[va264] (anti-nip antibody) / Homo sapiens
- Undefined site
Immunoglobulin gamma-3-[ya296] (anti-nip antibody) / Homo sapiens
- Undefined site
Immunoglobulin heavy constant alpha 1 / Homo sapiens
- Undefined site
- Asn-144
- Asn-340
Immunoglobulin heavy constant delta / Homo sapiens
- Undefined site
- Asn-225
Immunoglobulin heavy constant epsilon - heavy chain 1 / Homo sapiens
- Undefined site
Immunoglobulin heavy constant epsilon - heavy chain 2 / Homo sapiens
- Undefined site
Immunoglobulin heavy constant gamma 2 / Homo sapiens
- Undefined site
Immunoglobulin heavy constant gamma 2 - heavy chain 1 / Homo sapiens
- Undefined site
Immunoglobulin heavy constant mu / Homo sapiens
- Undefined site
- Asn-46
- Asn-279
- Asn-439
- Asn-440

Mass spectrometry observed peptide

YKNNSDISSTR (11aa)
- P01871 Asn-46 Immunoglobulin heavy constant mu / Homo sapiens
NNSDISSTR (9aa)
- P01871 Asn-46 Immunoglobulin heavy constant mu / Homo sapiens
RLSLHRPALEDLLLGSEANLTCTLTGLRD (29aa)
- P01876 Asn-144 Immunoglobulin heavy constant alpha 1 / Homo sapiens
LSLHRPALEDLLLGSEANLTCTLTGLR (27aa)
- P01877 Asn-144 Immunoglobulin alpha (non secretory) / Homo sapiens
- P01876 Asn-144 Immunoglobulin alpha (non secretory) / Homo sapiens
SHPNATFSAVGE (12aa)
- P01871 Asn-279 Immunoglobulin heavy constant mu / Homo sapiens
LAGKPTHVNVSVVMAEVDGTCY (22aa)
- P01876 Asn-340 Immunoglobulin heavy constant alpha 1 / Homo sapiens
KTIDRLAGKPTHVNVSVVMAEVDGTCY- (28aa)
- P01876 Asn-340 Immunoglobulin heavy constant alpha 1 / Homo sapiens
RLAGKPTHVNVSVVMAEVDGTCY- (24aa)
- P01876 Asn-340 Immunoglobulin heavy constant alpha 1 / Homo sapiens
KSTGKPTLYNVSLVMSDTAGTCY- (24aa)
- P01871 Asn-439 Immunoglobulin heavy constant mu / Homo sapiens
STGKPTLYNVSLV(MSO)SDTAGTCY (26aa)
- P01871 Asn-440 Immunoglobulin heavy constant mu / Homo sapiens

- N-Linked / High-Mannose (avg mass : 1397.2597)

Cross-references

GlyTouCan : G80966KZ

UniCarb-DB :

Composition

IUPAC

Man(a1-3)[Man(a1-6)]Man(a1-6)[Man(a1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc

GlycoCT

RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:b-dglc-HEX-1:5
4s:n-acetyl
5b:b-dman-HEX-1:5
6b:a-dman-HEX-1:5
7b:a-dman-HEX-1:5
8b:a-dman-HEX-1:5
9b:a-dman-HEX-1:5
10b:a-dman-HEX-1:5
LIN
1:1d(2+1)2n
2:1o(4+1)3d
3:3d(2+1)4n
4:3o(4+1)5d
5:5o(3+1)6d
6:6o(2+1)7d
7:5o(6+1)8d
8:8o(3+1)9d
9:8o(6+1)10d