Hex:1 HexNAc:1

Taxonomy

• Homo sapiens (Human)

Protein

• Immunoglobulin gamma-3 (anti-GDob1 allotype G3m(g) / monoclonal) / Homo sapiens    P01860
• Immunoglobulin gamma-3 (anti-GDob1 allotype G3m(s) / monoclonal) / Homo sapiens    P01860
• Immunoglobulin heavy constant alpha 1 / Homo sapiens    P01876
• Immunoglobulin heavy constant delta / Homo sapiens    P01880
• Immunoglobulin heavy constant gamma 3 / Homo sapiens    P01860
• Immunoglobulin heavy variable 4-39 / Homo sapiens    P01824

Source

• Blood (UBERON_0000178)  
• Blood Plasma (UBERON_0001969)  
• Blood Serum (UBERON_0001977)  
• Colostrum (UBERON_0001914)  
• Milk (UBERON_0001913)  
• HEK293-F (CVCL_6642)  

Reported structure

• O-Linked / Core 1 / Gal(b1-3)GalNAc
• O-Linked / Core 8 / Gal(a1-3)GalNAc
• O-Linked / Undefined core / Gal(?1-3)GalNAc

Composition

• Hex:1 HexNAc:1 (avg mass : 383.3527 )

Disease

• Control/Healthy
• Multiple myeloma (DOID:9538)
• Myeloma (DOID:0070004)

Reference

• Hinge-Region O-Glycosylation of Human Immunoglobulin G3 (IgG3) (2015 - Rosina Plomp, Gillian Dekkers, Yoann Rombouts, Remco Visser, Carolien A.M.Koeleman, Guinevere S.M.Kammeijer, Bas C.Jansen, Theo Rispens, Paul J.Hensbergen, Gestur Vidarsson, Manfred Wuhrer) / Status : Reviewed
• Naturally Occurring Structural Isomers in Serum IgA1 O-Glycosylation (2012 - Kazuo Takahashi, Archer D. Smith, IV, Knud Poulsen, Mogens Kilian, Bruce A. Julian, Jiri Mestecky, Jan Novak, Matthew B. Renfrow) / Status : Reviewed
• GlycoSpectrumScan: Fishing Glycopeptides from MS Spectra of Protease Digests of Human Colostrum sIgA (2010 - Nandan Deshpande, Pia H. Jensen, Nicolle H. Packer, Daniel Kolarich) / Status : Reviewed
• The Glycosylation of Human Serum IgD and IgE and the Accessibility of Identified Oligomannose Structures for Interaction with Mannan-Binding Lectin (2004 - James N. Arnold, Catherine M. Radcliffe, Mark R. Wormald, Louise Royle, David J. Harvey, Max Crispin, Raymond A. Dwek, Robert B. Sim and Pauline M. Rudd) / Status : Reviewed
• The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fc alpha receptor interactions. (1998 - Mattu T, Pleass R, Willis A, Kilian M, Wormald M, Lellouch A, Rudd P, Woof J, Dwek R) / Status : Reviewed
• Analysis of glycoform of O-glycan from human myeloma immunoglobulin A1 by gas-phase hydrazinolysis following pyridylamination of oligosaccharides. (1992 - Iwase H, Ishii-Karakasa I, Fujii E, Hotta K, Hiki Y, Kobayashi Y) / Status : Reviewed
• O-linked oligosaccharides from human serum immunoglobulin A1. (1989 - Field M, Dwek R, Edge C, Rademacher T) / Status : Reviewed
• Structures of the O-glycosidically linked oligosaccharides of human IgD. (1983 - Mellis S, Baenziger J) / Status : Reviewed
• Structures of the O-glycosidically linked oligosaccharides of human IgD. (1983 - S J Mellis, J U Baenziger) / Status : Reviewed
• Heterogeneity of the glycans O-glycosidically linked to the hinge region of secretory immunoglobulins from human milk. (1981 - Pierce-Cretel A, Pamblanco M, Strecker G, Montreuil J, Spik G) / Status : Reviewed
• Structure of the carbohydrate units of IgA1 immunoglobulin. II. Stucture of the O-glycosidically linked oligosaccharide units. (1974 - Baenziger J, Kornfeld S) / Status : Reviewed

Reported glycosite

• Immunoglobulin gamma-3 (anti-GDob1 allotype G3m(g) / monoclonal) / Homo sapiens
  •        Thr-122
  •        Thr-137
  •        Thr-152
• Immunoglobulin gamma-3 (anti-GDob1 allotype G3m(s) / monoclonal) / Homo sapiens
  •        Thr-122
  •        Thr-137
  •        Thr-152
• Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •        Undefined site
  •        Thr-106
  •        Thr-109
  •        Ser-111
  •        Ser-113
  •        Thr-114
  •        Thr-117
  •        Ser-119
  •        Ser-121
• Immunoglobulin heavy constant delta / Homo sapiens
  •        Undefined site
  •        Ser-109
  •        Thr-126
  •        Thr-127
  •        Thr-131
  •        Thr-132
• Immunoglobulin heavy constant gamma 3 / Homo sapiens
  •        Thr-122
  •        Thr-137
  •        Thr-152
• Immunoglobulin heavy variable 4-39 / Homo sapiens
  •        Undefined site

Mass spectrometry observed peptide

• HYTNPSQDVTVPCPVPSTPPTPSP (24aa)
  •    P01876    Thr-109     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Ser-111     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Thr-106     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Ser-113     Immunoglobulin heavy constant alpha 1 / Homo sapiens
• STPPTPSPSCCHPR (14aa)
  •    P01876    Thr-117     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Thr-114     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Ser-113     Immunoglobulin heavy constant alpha 1 / Homo sapiens
• SCDTPPPCPR (10aa)
  •    P01860    Thr-137     Immunoglobulin gamma-3 (anti-GDob1 allotype G3m(g) / monoclonal) / Homo sapiens
  •    P01860    Thr-152     Immunoglobulin gamma-3 (anti-GDob1 allotype G3m(s) / monoclonal) / Homo sapiens
  •    P01860    Thr-122     Immunoglobulin heavy constant gamma 3 / Homo sapiens
  •    P01860    Thr-137     Immunoglobulin heavy constant gamma 3 / Homo sapiens
  •    P01860    Thr-137     Immunoglobulin gamma-3 (anti-GDob1 allotype G3m(s) / monoclonal) / Homo sapiens
  •    P01860    Thr-122     Immunoglobulin gamma-3 (anti-GDob1 allotype G3m(g) / monoclonal) / Homo sapiens
  •    P01860    Thr-152     Immunoglobulin heavy constant gamma 3 / Homo sapiens
  •    P01860    Thr-122     Immunoglobulin gamma-3 (anti-GDob1 allotype G3m(s) / monoclonal) / Homo sapiens
  •    P01860    Thr-152     Immunoglobulin gamma-3 (anti-GDob1 allotype G3m(g) / monoclonal) / Homo sapiens