Tryptase alpha/beta-1

Taxonomy

• Homo sapiens (Human)

Protein

• Tryptase alpha/beta-1 / Homo sapiens    Q15661

Source

• Mammary Gland (UBERON_0001911)  

Reported structure

Composition

• Hex:3 HexNAc:2 (avg mass : 910.8325 )
• Hex:3 HexNAc:2 dHex:1 (avg mass : 1056.9755 )
• Hex:4 HexNAc:2 dHex:1 (avg mass : 1219.1179 )
• Hex:4 HexNAc:3 dHex:1 NeuAc:1 (avg mass : 1713.5708 )
• Hex:5 HexNAc:2 (avg mass : 1235.1173 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:2 (avg mass : 2370.1661 )
• Hex:5 HexNAc:5 dHex:1 NeuAc:2 (avg mass : 2573.3611 )
• Hex:6 HexNAc:2 (avg mass : 1397.2597 )
• Hex:6 HexNAc:3 NeuAc:1 (avg mass : 1891.7126 )
• Hex:6 HexNAc:3 dHex:1 NeuAc:1 (avg mass : 2037.8556 )
• Hex:12 HexNAc:2 (avg mass : 2370.1141 )

Disease

• Cancer, breast (DOID:1612)

Reference

• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed

Reported glycosite

• Tryptase alpha/beta-1 / Homo sapiens
  •        Asn-132
  •        Asn-233

Mass spectrometry observed peptide

• IIVHPQFYIIQTGADIALLELEEPVNISSR (30aa)
  •    Q15661    Asn-132     Tryptase alpha/beta-1 / Homo sapiens
  •    VAR_064285   115:T→I   dbSNP:rs199625169
  •    VAR_064286   116:A→I
  •    VAR_064287   118:I→T   dbSNP:rs202044288
  •    VAR_064288   133:V→I   dbSNP:rs200334042
  •    VAR_051830   136:H→R   dbSNP:rs1064780
• VNGTWLQAGVVSWDEGCAQPNRPGIYTR (28aa)
  •    Q15661    Asn-233     Tryptase alpha/beta-1 / Homo sapiens
• VNGTWLQAGVVSWGEGCAQPNRPGIYTR (28aa)
  •    Q15661    Asn-233     Tryptase alpha/beta-1 / Homo sapiens