GlyConnect

Taxonomy (1) Protein (1) Source (1) Structure (0) Composition (12) Disease (1) Site (2) Peptide (3)

Taxonomy

Homo sapiens (Human)

Protein

Tryptase alpha/beta-1 / Homo sapiens Q15661

Source

Mammary Gland (UBERON_0001911)

Reported structure

Composition

Disease

Cancer, breast (DOID:1612)

Reported glycosite

Tryptase alpha/beta-1 / Homo sapiens :
- Asn-132
- Asn-233

Mass spectrometry validated peptide

IIVHPQFYIIQTGADIALLELEEPVNISSR (30aa)
- Q15661 Asn-132
- VAR_064285 115:T→I dbSNP:rs199625169
- VAR_064286 116:A→I
- VAR_064287 118:I→T dbSNP:rs202044288
- VAR_064288 133:V→I dbSNP:rs200334042
- VAR_051830 136:H→R dbSNP:rs1064780
VNGTWLQAGVVSWGEGCAQPNRPGIYTR (28aa)
- Q15661 Asn-233
VNGTWLQAGVVSWDEGCAQPNRPGIYTR (28aa)
- Q15661 Asn-233

- Hex:6 HexNAc:3 NeuAc:1 (avg mass : 1891.7126 )
- Hex:5 HexNAc:5 dHex:1 NeuAc:2 (avg mass : 2573.3611 )
- Hex:4 HexNAc:2 dHex:1 (avg mass : 1219.1179 )
- Hex:4 HexNAc:3 dHex:1 NeuAc:1 (avg mass : 1713.5708 )
- Hex:6 HexNAc:3 dHex:1 NeuAc:1 (avg mass : 2037.8556 )
- Hex:12 HexNAc:2 (avg mass : 2370.1141 )
- Hex:6 HexNAc:2 (avg mass : 1397.2597 )
- Hex:5 HexNAc:2 (avg mass : 1235.1173 )
- Hex:5 HexNAc:4 dHex:1 NeuAc:2 (avg mass : 2370.1661 )
- Hex:3 HexNAc:2 dHex:1 (avg mass : 1056.9755 )
- Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )
- Hex:3 HexNAc:2 (avg mass : 910.8325 )

Protein and gene references

UniProtKB : Q15661

neXtProt : NX_Q15661

GeneCards : TPSAB1

3D structure from PDB

Select a PDB entry

Github Wiki

3D visualization by LiteMol

References (1)

Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018)
Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang
Pubmed : 29741879 DOI : 10.1021/acs.analchem.8b01137
Status : Unreviewed