Title Year Authors Journal Status External references Biological associations
Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies for Glycopeptide Analysis 2021 Rebeca Kawahara, Kathirvel Alagesan, Marshall Bern, Meng Bo, Weiqian Cao, Robert J Chalkley, Kai Cheng, Matthew S. Choo, Nathan Edwards, Radoslav Goldman, Marcus Hoffmann, Yingwei Hu, Yifan Huang, Jin Young Kim, Doron Kletter, Benoit Liquet-Weiland, Mingqi Liu, Yehia Mechref, Sriram Neelamegham, Terry Nguyen-Khuong, Jonas Nilsson, Adam Pap, Gun Wook Park, Benjamin L. Parker, Cassandra L. Pegg, Josef M. Penninger, Toan K. Phung, Markus Pioch, Erdmann Rapp, Enes Sakalli, Miloslav Sanda, Benjamin L. Schulz, Nichollas Scott, Georgy Sofronov, Johannes Stadlmann, Sergey Vakhrushev, Christina Woo, Hung-Yi Wu, Pengyuan Yang, Wantao Ying, Zhang Yong, Hui Zhang, Jingfu Zhao, Joseph Zaia, Stuart M. Haslam, Giuseppe Palmisano, Jong Shin Yoo, Goran Larson, Kai-Hooi Khoo, Katalin F. Medzihradszky, Daniel Kolarich, Nicolle H. Packer, and Morten Thaysen-Andersen bioRxiv Reviewed

    Reported structure

    Disease

Site-specific O-glycosylation analysis of SARS-CoV-2 spike protein produced in insect and human cells 2021 Ieva Bagdonaite, Andrew J. Thompson, Xiaoning Wang, Max Søgaard, Cyrielle Fougeroux, Martin Frank, Jolene K. Diedrich, John R. Yates 3rd, Ali Salanti, Sergey Y. Vakhrushev, James C. Paulson, Hans H. Wandall Viruses Reviewed

    Protein

    Reported glycosite

Cysteine Aminoethylation Enables the Site-Specific Glycosylation Analysis of Recombinant Human Erythropoietin using Trypsin 2020 Steffen Lippold, Alexander Büttner, Matthew S.F. Choo, Michaela Hook, Coen J. de Jong, Terry Nguyen-Khuong, Markus Haberger, Dietmar Reusch, Manfred Wuhrer, Noortje de Haan Anal Chem Reviewed

    Disease

Quantitative Longitudinal Inventory of the N-Glycoproteome of Human Milk from a Single Donor Reveals the Highly Variable Repertoire and Dynamic Site-Specific Changes 2020 Jing Zhu, Yu-Hsien Lin, Kelly A Dingess, Marko Mank, Bernd Stahl, Albert J R Heck J Proteome Res Reviewed

    Disease

Identification of protein O-glycosylation site and corresponding glycans using liquid chromatography-tandem mass spectrometry via mapping accurate mass and retention time shift 2014 Huang LJ, Lin JH, Tsai JH, Chu YY, Chen YW, Chen SL, Chen SH J Chromatogr A Reviewed

    Source

    Disease

    Mass spectrometry observed peptide

The O-glycomap of lubricin, a novel mucin responsible for joint lubrication, identified by site-specific glycopeptide analysis 2014 Ali L, Flowers SA, Jin C, Bennet EP, Ekwall AK, Karlsson NG Mol Cell Proteomics Reviewed

    Mass spectrometry observed peptide

Identification of N-linked glycosylation and putative O-fucosylation, C-mannosylation sites in plasma derived ADAMTS13 2014 Sorvillo N, Kaijen PH, Matsumoto M, Fujimura Y, van der Zwaan C, Verbij FC, Pos W, Fijnheer R, Voorberg J, Meijer AB J Thromb Haemost Reviewed

    Disease

    Mass spectrometry observed peptide

Electron Transfer Dissociation (ETD): The Mass Spectrometric Breakthrough Essential for O-GlcNAc Protein Site Assignments-A Study of the O-GlcNAcylated Protein Host Cell Factor C1 2013 Samuel A Myers, Salima Daou, El Bachir Affar, Al Burlingame Proteomics Reviewed

    Disease

Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD 2012 Halim A, Nilsson J, Rüetschi U, Hesse C, Larson G Mol Cell Proteomics Reviewed

    Reported structure

    Disease

    Mass spectrometry observed peptide

Determination of site-specific glycan heterogeneity on glycoproteins 2012 Kolarich D1, Jensen PH, Altmann F, Packer NH. Nat Protoc Reviewed

    Source

    Disease

    Mass spectrometry observed peptide

Naturally Occurring Structural Isomers in Serum IgA1 O-Glycosylation 2012 Kazuo Takahashi, Archer D. Smith, IV, Knud Poulsen, Mogens Kilian, Bruce A. Julian, Jiri Mestecky, Jan Novak, Matthew B. Renfrow J Proteome Res Reviewed
Modification of Histones by Sugar β-N-acetylglucosamine (GlcNAc) Occurs on Multiple Residues, Including Histone H3 Serine 10, and Is Cell Cycle-Regulated 2011 Suisheng Zhang, Kevin Roche, Heinz-Peter Nasheuer, Noel Francis Lowndes J Biol Chem Reviewed

    Protein

  • Histone H3 / Homo sapiens    P68431

    Disease

Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody 2011 Scott A Yuzwa, Anuj K Yadav, Yuliya Skorobogatko, Thomas Clark, Keith Vosseller, David J Vocadlo Amino acids Unreviewed

    Source

    Disease

Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation 2011 Caroline Smet-Nocca, Malgorzata Broncel, Jean-Michel Wieruszeski, Caroline Tokarski, Xavier Hanoulle, Arnaud Leroy, Isabelle Landrieu, Christian Rolando, Guy Lippens, Christian P R Hackenberger Mol Biosyst Unreviewed

    Source

    Disease

Extensive Crosstalk Between O-GlcNAcylation and Phosphorylation Regulates Cytokinesis 2010 Zihao Wang, Namrata D Udeshi, Chad Slawson, Philip D Compton, Kaoru Sakabe, Win D Cheung, Jeffrey Shabanowitz, Donald F Hunt, Gerald W Hart Sci Signal Reviewed

    Disease

Affinity enrichment and characterization of mucin core-1 type glycopeptides from bovine serum 2009 Darula Z, Medzihradszky KF. Mol Cell Proteomics Reviewed

    Reported structure

    Disease

    Mass spectrometry observed peptide

Site-specific GlcNAcylation of Human Erythrocyte Proteins: Potential Biomarker(s) for Diabetes 2009 Zihao Wang, Kyoungsook Park, Frank Comer, Linda C Hsieh-Wilson, Christopher D Saudek, Gerald W Hart Diabetes Reviewed

    Disease

Loss of p53 Enhances Catalytic Activity of IKKbeta Through O-linked beta-N-acetyl Glucosamine Modification 2009 Keiko Kawauchi, Keigo Araki, Kei Tobiume, Nobuyuki Tanaka Proc Natl Acad Sci USA Reviewed

    Disease

O-GlcNAc Regulates FoxO Activation in Response to Glucose 2008 Michael P Housley, Joseph T Rodgers, Namrata D Udeshi, Timothy J Kelly, Jeffrey Shabanowitz, Donald F Hunt, Pere Puigserver, Gerald W Hart J Biol Chem Reviewed
The diversity of O-linked glycans expressed during Drosophila melanogaster development reflects stage- and tissue-specific requirements for cell signaling. 2008 Kazuhiro Aoki, Mindy Porterfield, Samuel S Lee, Brian Dong, Khoi Nguyen, Katherine H McGlamry, Michael Tiemeyer J Biol Chem Reviewed

    Protein

    Disease

    Reported glycosite

    Mass spectrometry observed peptide

Glycomic studies of Drosophila melanogaster embryos. 2006 Simon J North, Kate Koles, Caleb Hembd, Howard R Morris, Anne Dell, Vladislav M Panin, Stuart M Haslam Glycoconj J Reviewed

    Protein

    Disease

    Reported glycosite

    Mass spectrometry observed peptide

Occurrence of O-linked Xyl-GlcNAc and Xyl-Glc disaccharides in trocarin, a factor Xa homolog from snake venom 2003 Joseph JS, Valiyavettil M, Gowda DC, Kini RM J Thromb Haemost Reviewed

    Disease

    Mass spectrometry observed peptide

The capsid protein of a plant single-stranded RNA virus is modified by O-linked N-acetylglucosamine 2002 Fernandez-Fernandez, Camafeita, Bonay, Mendez, Albar, Garcia J Biol Chem Reviewed

    Source

    Disease

    Mass spectrometry observed peptide

Intestinal mucins from cystic fibrosis mice show increased fucosylation due to an induced Fucalpha1-2 glycosyltransferase. 2002 Thomsson KA, Hinojosa-Kurtzberg M, Axelsson KA, Domino SE, Lowe JB, Gendler SJ, Hansson GC Biochem J Reviewed

    Protein

  • Muc2 / Mus musculus    

    Mass spectrometry observed peptide

C-mannosylation and O-fucosylation of the thrombospondin type 1 module. 2001 Hofsteenge J, Huwiler K, Macek B, Hess D, Lawler J, Mosher D, Peter-Katalinic J J Biol Chem Reviewed

    Mass spectrometry observed peptide

Neutralization of pH in the Golgi apparatus causes redistribution of glycosyltransferases and changes in the O-glycosylation of mucins. 2001 Axelsson M, Karlsson N, Steel D, Ouwendijk J, Nilsson T, Hansson G Glycobiology Reviewed

    Protein

  • Unspecified mucin / Homo sapiens    

    Mass spectrometry observed peptide

Glycosylated polyproline II rods with kinks as a structural motif in plant hydroxyproline-rich glycoproteins 2001 Ferris, Woessner, Waffenschmidt, Kilz, Drees, Goodenough Biochemistry Reviewed

    Disease

    Mass spectrometry observed peptide

Multiple O-glycoforms on the spore coat protein SP96 in Dictyostelium discoideum. Fuc(alpha1-3)GlcNAc-alpha-1-P-Ser is the major modification. 2000 Mreyen M, Champion A, Srinivasan S, Karuso P, Williams K, Packer N J Biol Chem Reviewed

    Disease

    Mass spectrometry observed peptide

Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modules. 2000 Moloney D, Shair L, Lu F, Xia J, Locke R, Matta K, Haltiwanger R J Biol Chem Reviewed

    Protein

  • Notch 1 / Cricetulus griseus    

    Disease

    Mass spectrometry observed peptide

Isolation and characterization of glycophorin from nucleated (chicken) erythrocytes. 2000 Duk M, Krotkiewski H, Stasyk T, Lutsik-Kordovsky M, Syper D, Lisowska E Arch Biochem Biophys Reviewed

    Protein

  • Glycophorin / Gallus gallus    

    Disease

    Mass spectrometry observed peptide

Alternative O-glycosylation/O-phosphorylation of the murine estrogen receptor beta. 2000 Cheng X, Cole R, Zaia J, Hart G Biochemistry Reviewed

    Disease

    Mass spectrometry observed peptide

Functional analysis of O-linked oligosaccharides in threonine/serine-rich region of Aspergillus glucoamylase by expression in mannosyltransferase-disruptants of yeast. 1999 Goto M, Tsukamoto M, Kwon I, Ekino K, Furukawa K Eur J Biochem Reviewed

    Source

    Composition

  • Hex:1 (avg mass : 180.1577 )

    Disease

    Mass spectrometry observed peptide

X-ray crystallography and mass spectroscopy reveal that the N-lobe of human transferrin expressed in Pichia pastoris is folded correctly but is glycosylated on serine-32. 1999 Bewley M, Tam B, Grewal J, He S, Shewry S, Murphy M, Mason A, Woodworth R, Baker E, MacGillivray R Biochemistry Reviewed

    Source

    Reported structure

    Composition

  • Hex:1 (avg mass : 180.1577 )

    Disease

    Mass spectrometry observed peptide

Schizosaccharomyces pombe produces novel Gal0-2Man1-3 O-linked oligosaccharides. 1999 Gemmill T, Trimble R Glycobiology Reviewed

    Source

    Composition

  • Hex:1 (avg mass : 180.1577 )

    Disease

    Mass spectrometry observed peptide

High prevalence of 2-mono- and 2,6-di-substituted manol-terminating sequences among O-glycans released from brain glycopeptides by reductive alkaline hydrolysis. 1999 Chai W, Yuen C, Kogelberg H, Carruthers R, Margolis R, Feizi T, Lawson A Eur J Biochem Reviewed

    Disease

    Mass spectrometry observed peptide

Purification and characterization of the MUC1 mucin-type glycoprotein, epitectin, from human urine: structures of the major oligosaccharide alditols. 1998 Bhavanandan V, Zhu Q, Yamakami K, Dilulio N, Nair S, Capon C, Lemoine J, Fournet B Glycoconj J Reviewed

    Protein

  • Mucin-1 / Homo sapiens    P15941

    Mass spectrometry observed peptide

Structural analysis of oligosaccharide-alditols released by reductive beta-elimination from the jelly coats of the anuran Bufo arenarum. 1998 Morelle W, Cabada M, Strecker G Eur J Biochem Reviewed

    Protein

  • Mucin / Bufo arenarum    

    Disease

    Mass spectrometry observed peptide

Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity. 1998 Prakobphol A, Thomsson K, Hansson G, Rosen S, Singer M, Phillips N, Medzihradszky K, Burlingame A, Leffler H, Fisher S Biochemistry Reviewed

    Protein

  • Mucin-7 / Homo sapiens    Q8TAX7

    Disease

    Mass spectrometry observed peptide

Reduction of O-linked N-acetylglucosamine-modified assembly protein-3 in Alzheimer's disease. 1998 Yao P, Coleman P J Neurosci Reviewed

    Mass spectrometry observed peptide

SV40 large T antigen is modified with O-linked N-acetylglucosamine but not with other forms of glycosylation. 1998 Medina L, Grove K, Haltiwanger R Glycobiology Reviewed

    Disease

    Mass spectrometry observed peptide

Structure of the O-glycopeptides isolated from bovine milk component PP3. 1998 Coddeville B, Girardet J, Plancke Y, Campagna S, Linden G, Spik G Glycoconj J Reviewed

    Protein

  • Lactophorin / Bos taurus    P80195

    Disease

    Mass spectrometry observed peptide

Structural study of the O-linked sugar chains of human leukocyte tyrosine phosphatase CD45. 1998 Furukawa K, Funakoshi Y, Autero M, Horejsi V, Kobata A, Gahmberg C Eur J Biochem Reviewed

    Disease

    Mass spectrometry observed peptide

An evaluation of sialation of the nucleoporin p62. 1998 Fang B, Hanover J, Miller M Arch Biochem Biophys Reviewed

    Mass spectrometry observed peptide

Detection of O-mannosyl glycans in rabbit skeletal muscle alpha-dystroglycan. 1998 Sasaki T, Yamada H, Matsumura K, Shimizu T, Kobata A, Endo T Biochim Biophys Acta Reviewed

    Composition

  • Hex:1 (avg mass : 180.1577 )

    Disease

    Mass spectrometry observed peptide

Phosphorylation and O-glycosylation sites of human chromogranin A (CGA79-439) from urine of patients with carcinoid tumors. 1998 Gadroy P, Stridsberg M, Capon C, Michalski J, Strub J, Van Dorsselaer A, Aunis D, Metz-Boutigue M J Biol Chem Reviewed

    Mass spectrometry observed peptide

Neutral core oligosaccharides of bovine submaxillary mucin--use of lead tetraacetate in the cold for establishing branch positions. 1998 Martensson S, Levery S, Fang T, Bendiak B Eur J Biochem Reviewed

    Protein

  • Mucin / Bos taurus    

    Disease

    Mass spectrometry observed peptide

Cytochrome b558/566 from the archaeon Sulfolobus acidocaldarius. A novel highly glycosylated, membrane-bound b-type hemoprotein. 1998 Hettmann T, Schmidt C, Anemller S, Zhringer U, Moll H, Petersen A, Schfer G J Biol Chem Reviewed

    Composition

  • Hex:1 (avg mass : 180.1577 )

    Disease

    Mass spectrometry observed peptide

Structural analysis of the oligosaccharide-alditols released by reductive beta-elimination from oviducal mucins of Rana temporaria. 1997 Maes E, Florea D, Delplace F, Lemoine J, Plancke Y, Strecker G Glycoconj J Reviewed

    Protein

  • Mucin / Rana temporaria    

    Disease

    Mass spectrometry observed peptide

Structure of the O-linked oligosaccharides from a major thyroid cell surface glycoprotein. 1997 Edge A, Spiro R Arch Biochem Biophys Reviewed

    Protein

  • Gp-3 / Bos taurus    

    Disease

    Mass spectrometry observed peptide

The glycosylation of rat intestinal Muc2 mucin varies between rat strains and the small and large intestine. A study of O-linked oligosaccharides by a mass spectrometric approach. 1997 Karlsson N, Herrmann A, Karlsson H, Johansson M, Carlstedt I, Hansson G J Biol Chem Reviewed

    Disease

    Mass spectrometry observed peptide

Glycosylation analysis and protein structure determination of murine fetal antigen 1 (mFA1)--the circulating gene product of the delta-like protein (dlk), preadipocyte factor 1 (Pref-1) and stromal-cell-derived protein 1 (SCP-1) cDNAs. 1997 Krogh T, Bachmann E, Teisner B, Skjdt K, Hjrup P Eur J Biochem Reviewed

    Disease

    Mass spectrometry observed peptide

A subpopulation of estrogen receptors are modified by O-linked N-acetylglucosamine. 1997 Jiang M, Hart G J Biol Chem Reviewed

    Mass spectrometry observed peptide

Sulphated mucin oligosaccharides from porcine small intestine analysed by four-sector tandem mass spectrometry. 1996 Karlsson N, Karlsson H, Hansson G J Mass Spectrom Reviewed

    Protein

  • Mucin / Sus scrofa    

    Disease

    Mass spectrometry observed peptide

Mucin-type glycoprotein from Drosophila melanogaster embryonic cells: characterization of carbohydrate component. 1996 Kramerov A, Arbatsky N, Rozovsky Y, Mikhaleva E, Polesskaya O, Gvozdev V, Shibaev V FEBS Lett Reviewed

    Disease

    Mass spectrometry observed peptide

Identification of O-linked N-acetylglucosamine modification of ankyrinG isoforms targeted to nodes of Ranvier. 1996 Zhang X, Bennett V J Biol Chem Reviewed

    Protein

  • Ankyrin 3 / Bos taurus    E1BNC9

    Disease

    Mass spectrometry observed peptide

Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246. 1996 Hoffman RC, Andersen H, Walker K, Krakover JD, Patel S, Stamm MR, Osborn SG Biochemistry Reviewed

    Disease

    Mass spectrometry observed peptide

Comparison of O-linked carbohydrate chains in MUC-1 mucin from normal breast epithelial cell lines and breast carcinoma cell lines. Demonstration of simpler and fewer glycan chains in tumor cells. 1996 Lloyd KO, Burchell J, Kudryashov V, Yin BW, Taylor-Papadimitriou J J Biol Chem Reviewed

    Protein

  • Mucin-1 / Homo sapiens    P15941

    Mass spectrometry observed peptide

Insect immunity. The inducible antibacterial peptide diptericin carries two O-glycans necessary for biological activity. 1995 Bulet P, Hegy G, Lambert J, van Dorsselaer A, Hoffmann J, Hetru C Biochemistry Reviewed

    Disease

    Mass spectrometry observed peptide

The serine-rich Entamoeba histolytica protein is a phosphorylated membrane protein containing O-linked terminal N-acetylglucosamine residues. 1995 Stanley Jr S, Tian K, Koester J, Li E J Biol Chem Reviewed

    Source

    Disease

    Mass spectrometry observed peptide

c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas. 1995 Chou T, Hart G, Dang C J Biol Chem Reviewed

    Disease

    Mass spectrometry observed peptide

Identification and mutational analysis of the glycosylation sites of human keratin 18. 1995 Ku N, Omary M J Biol Chem Reviewed

    Mass spectrometry observed peptide

Altered sialylation of CD45 in HIV-1-infected T lymphocytes. 1994 Lefebvre J, Giordanengo V, Doglio A, Cagnon L, Breittmayer J, Peyron J, Lesimple J Virology Reviewed

    Mass spectrometry observed peptide

O- and N-glycosylation of the Leishmania mexicana-secreted acid phosphatase. Characterization of a new class of phosphoserine-linked glycans. 1994 Ilg T, Overath P, Ferguson M, Rutherford T, Campbell D, McConville M J Biol Chem Reviewed

    Disease

    Mass spectrometry observed peptide

Site-specific glycosylation of the human cytomegalovirus tegument basic phosphoprotein (UL32) at serine 921 and serine 952. 1994 Greis K, Gibson W, Hart G J Virol Reviewed

    Disease

    Mass spectrometry observed peptide

Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2. 1993 Carlsson S, Lycksell P, Fukuda M Arch Biochem Biophys Reviewed

    Mass spectrometry observed peptide

O-linked neutral sugar chains of porcine zona pellucida glycoproteins. 1993 Hirano T, Takasaki S, Hedrick J, Wardrip N, Amano J, Kobata A Eur J Biochem Reviewed

    Disease

    Mass spectrometry observed peptide

Studies on O-glycans of Plasmodium-falciparum-infected human erythrocytes. Evidence for O-GlcNAc and O-GlcNAc-transferase in malaria parasites. 1993 Dieckmann-Schuppert A, Bause E, Schwarz R Eur J Biochem Reviewed

    Mass spectrometry observed peptide

Characterization of two different glycosylated domains from the insoluble mucin complex of rat small intestine. 1993 Carlstedt I, Herrmann A, Karlsson H, Sheehan J, Fransson L, Hansson G J Biol Chem Reviewed

    Disease

    Mass spectrometry observed peptide

Structures of mucin-type sugar chains on human erythropoietins purified from urine and the culture medium of recombinant Chinese hamster ovary cells. 1993 Inoue N, Takeuchi M, Asano K, Shimizu R, Takasaki S, Kobata A Arch Biochem Biophys Reviewed