Colon

Taxonomy

• Homo sapiens (Human)

Protein

• Keratin, type i cytoskeletal 18 / Homo sapiens    P05783
• Keratin, type II cytoskeletal 8 / Homo sapiens    P05787
• Muc1f (delta tr) / Homo sapiens    P15941
• Mucin / Homo sapiens
• Recombinant Mucin-1 Muc1f (delta tr) / Homo sapiens    P15941
• Recombinant Mucin-1 Muc1f/2tr / Homo sapiens    P15941    Q02817
• Recombinant Mucin-1 Muc1f/4tr / Homo sapiens    P15941    Q99102
• Recombinant Mucin-1 Muc1f/5actr / Homo sapiens    P15941    P98088
• Recombinant Mucin-1 Muc1f/5btr / Homo sapiens    P15941    Q9HC84
• Rgm / Homo sapiens

Source

• Colon (UBERON_0001155)   Caco-2 (CVCL_0025)  
• Colon (UBERON_0001155)   HT-29 (CVCL_0320)  
• Colon (UBERON_0001155)   LS174T (CVCL_1384)  
• Colon (UBERON_0001155)  

Reported structure

• O-Linked / Core 0 / GalNAc
• N-Linked/O-Linked / Truncated If N-Linked / GlcNAc
• O-Linked / Undefined core / GlcNAc
• O-Linked / Undefined core / Gal(?1-3)GalNAc
• O-Linked / Core 1 / Gal(b1-3)GalNAc
• O-Linked / Undefined core / NeuAc(?2-6)GalNAc
• O-Linked / Core 0 / NeuAc(a2-6)GalNAc
• O-Linked / No-core / Fuc(?1-?)Gal(?1-3)GalNAc
• O-Linked / Core 1 / Fuc(a1-2)Gal(b1-3)GalNAc
• O-Linked / Undefined core / Gal(?1-3)[GlcNAc(?1-6)]GalNAc
• O-Linked / Undefined core / Gal(b1-3)GalNAc+"+ GlcNAc(?1-?)"
• O-Linked / Undefined core / GlcNAc(?1-?)Gal(?1-3)GalNAc
• O-Linked / Undefined core / Gal(?1-3)[NeuAc(?2-6)]GalNAc
• O-Linked / Core 1 / Gal(b1-3)[NeuAc(a2-6)]GalNAc
• O-Linked / Core 1 / Gal(b1-3)GalNAc+"+ NeuAc(a2-?)"
• O-Linked / Undefined core / NeuAc(?2-?)Gal(?1-3)GalNAc
• O-Linked / Core 5 / GalNAc(a1-3)[NeuAc(a2-6)]GalNAc
• O-Linked / Core 3 / GlcNAc(b1-3)[NeuAc(a2-6)]GalNAc
• O-Linked / No-core / Gal(?1-?)GlcNAc(?1-6)[Gal(?1-3)]GalNAc
• O-Linked / No-core / Gal(?1-?)GlcNAc(?1-?)Gal(?1-3)GalNAc
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc
• O-Linked / Undefined core / NeuAc(?2-?)Gal(?1-3)[GlcNAc(?1-6)]GalNAc
• O-Linked / No-core / Fuc(?1-?)[Gal(?1-?)]GlcNAc(?1-6)[Gal(?1-3)]GalNAc
• O-Linked / No-core / Fuc(?1-?)[Gal(?1-?)]GlcNAc(?1-?)Gal(?1-3)GalNAc
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc+"+ Fuc(a1-2)"
• O-Linked / No-core / Gal(?1-?)GlcNAc(?1-?)[GlcNAc(?1-?)]Gal(?1-3)GalNAc
• O-Linked / No-core / NeuAc(?2-?)Gal(?1-3)[NeuAc(?2-6)]GalNAc
• O-Linked / Core 1 / NeuAc(a2-?)Gal(b1-3)[NeuAc(a2-6)]GalNAc
• O-Linked / Undefined core / Gal(?1-?)GlcNAc(?1-6)[NeuAc(?2-?)Gal(?1-3)]GalNAc
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc+"+ NeuAc(a2-?)"
• O-Linked / No-core / NeuAc(?2-?)Gal(?1-?)GlcNAc(?1-6)[Gal(?1-3)]GalNAc
• O-Linked / No-core / Fuc(?1-?)Gal(?1-?)[Fuc(?1-?)]GlcNAc(?1-?)Gal(?1-3)GalNAc
• O-Linked / No-core / Gal(?1-?)GlcNAc(?1-?)[Gal(?1-?)GlcNAc(?1-?)]Gal(?1-3)GalNAc
• O-Linked / Undefined core / Gal(b1-3)GalNAc+"+ 2 x Gal(b1-4)GlcNAc(b1-?)"
• O-Linked / No-core / Fuc(?1-?)[Gal(?1-?)]GlcNAc(?1-6)[NeuAc(?2-?)Gal(?1-3)]GalNAc
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc+"+ Fuc(a1-2) + NeuAc(a2-?)"
• O-Linked / No-core / Fuc(?1-?)[Gal(?1-?)]GlcNAc(?1-?)[Gal(?1-?)GlcNAc(?1-?)]Gal(?1-3)GalNAc
• O-Linked / Core 2 / NeuAc(a2-?)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-?)Gal(b1-3)]GalNAc

Composition

• HexNAc:1 (avg mass : 221.2103 )
• HexNAc:1 NeuAc:1 (avg mass : 512.4682 )
• HexNAc:2 NeuAc:1 (avg mass : 715.6632 )
• Hex:1 HexNAc:1 (avg mass : 383.3527 )
• Hex:1 HexNAc:1 NeuAc:1 (avg mass : 674.6106 )
• Hex:1 HexNAc:1 NeuAc:2 (avg mass : 965.8685 )
• Hex:1 HexNAc:1 dHex:1 (avg mass : 529.4957 )
• Hex:1 HexNAc:2 (avg mass : 586.5477 )
• Hex:1 HexNAc:2 NeuAc:1 (avg mass : 877.8056 )
• Hex:2 HexNAc:2 (avg mass : 748.6901 )
• Hex:2 HexNAc:2 NeuAc:1 (avg mass : 1039.948 )
• Hex:2 HexNAc:2 NeuAc:2 (avg mass : 1331.2059 )
• Hex:2 HexNAc:2 dHex:1 (avg mass : 894.8331 )
• Hex:2 HexNAc:2 dHex:1 NeuAc:1 (avg mass : 1186.091 )
• Hex:2 HexNAc:2 dHex:2 (avg mass : 1040.9761 )
• Hex:2 HexNAc:3 (avg mass : 951.8851 )
• Hex:3 HexNAc:3 (avg mass : 1114.0275 )
• Hex:3 HexNAc:3 dHex:1 (avg mass : 1260.1705 )

Disease

• Adenocarcinoma (DOID:299)
• Adenocarcinoma, Grade II (DOID:299)

Reference

• In vivo glycosylation of mucin tandem repeats (2001 - Silverman, Parry, Sutton-Smith, Burdick, McDermott, Reid, Batra, Morris, Hollingsworth, Dell, Harris) / Status : Reviewed
• Neutralization of pH in the Golgi apparatus causes redistribution of glycosyltransferases and changes in the O-glycosylation of mucins. (2001 - Axelsson M, Karlsson N, Steel D, Ouwendijk J, Nilsson T, Hansson G) / Status : Reviewed
• Identification and mutational analysis of the glycosylation sites of human keratin 18. (1995 - Ku N, Omary M) / Status : Reviewed
• Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18. (1991 - Chou C, Smith A, Omary M) / Status : Reviewed
• Structures of the major oligosaccharides from a human rectal adenocarcinoma glycoprotein. (1983 - Kurosaka A, Nakajima H, Funakoshi I, Matsuyama M, Nagayo T, Yamashina I) / Status : Reviewed

Reported glycosite

• Keratin, type i cytoskeletal 18 / Homo sapiens
  •        Ser-29
  •        Ser-30
  •        Ser-48
• Keratin, type II cytoskeletal 8 / Homo sapiens
  •        Undefined site
• Muc1f (delta tr) / Homo sapiens
  •        Undefined site
• Mucin / Homo sapiens
  •        Undefined site
• Recombinant Mucin-1 Muc1f (delta tr) / Homo sapiens
  •        Undefined site
• Recombinant Mucin-1 Muc1f/2tr / Homo sapiens
  •        Undefined site
• Recombinant Mucin-1 Muc1f/4tr / Homo sapiens
  •        Undefined site
• Recombinant Mucin-1 Muc1f/5actr / Homo sapiens
  •        Undefined site
• Recombinant Mucin-1 Muc1f/5btr / Homo sapiens
  •        Undefined site
• Rgm / Homo sapiens
  •        Undefined site

Mass spectrometry observed peptide