Mucosa of Small Intestine

Taxonomy

• Mus musculus (House mouse)
• Rattus norvegicus (Norway rat)

Protein

• Muc2 / Mus musculus
• Mucin / Rattus norvegicus

Source

• Mucosa of Small Intestine (UBERON_0001204)  

Reported structure

• O-Linked / Core 0 / GalNAc
• O-Linked / Undefined core / Gal(?1-3)GalNAc
• O-Linked / Core 1 / Fuc(a1-2)Gal(b1-3)GalNAc
• O-Linked / Undefined core / Gal(?1-3)[GlcNAc(?1-6)]GalNAc
• O-Linked / Core 1 / GalNAc(?1-?)Gal(?1-3)GalNAc
• O-Linked / Undefined core / GlcNAc(?1-?)Gal(?1-3)GalNAc
• O-Linked / Core 1 / NeuAc(a2-3)Gal(b1-3)GalNAc
• O-Linked / Undefined core / NeuGc(?2-?)Gal(?1-3)GalNAc
• O-Linked / Core 2 / Fuc(a1-2)Gal(b1-3)[GlcNAc(b1-6)]GalNAc
• O-Linked / Undefined core / Gal(?1-4)GlcNAc(?1-6)[Gal(?1-3)]GalNAc
• O-Linked / Core 2 / GalNAc(?1-?)Gal(?1-3)[GlcNAc(?1-6)]GalNAc
• O-Linked / Core 2 / GlcNAc(?1-?)Gal(?1-3)[GlcNAc(?1-6)]GalNAc
• O-Linked / Undefined core / GalNAc(?1-?)[NeuAc(?2-?)]Gal(?1-3)GalNAc
• O-Linked / Core 2 / NeuAc(a2-3)Gal(b1-3)[GlcNAc(b1-6)]GalNAc
• O-Linked / Undefined core / GalNAc(?1-?)[NeuGc(?2-?)]Gal(?1-3)GalNAc
• O-Linked / Undefined core / NeuGc(?2-?)Gal(?1-3)[GlcNAc(?1-6)]GalNAc
• O-Linked / Core 1 / Fuc(a1-2)Gal(?1-?)GlcNAc(?1-?)Gal(?1-3)GalNAc
• O-Linked / Core 2 / Fuc(a1-2)Gal(b1-3)[Gal(?1-?)GlcNAc(b1-6)]GalNAc
• O-Linked / Undefined core / Fuc(a1-2)Gal(b1-3)GlcNAc(?1-6)[Gal(?1-3)]GalNAc
• O-Linked / Undefined core / Fuc(a1-2)Gal(b1-4)GlcNAc(?1-6)[Gal(?1-3)]GalNAc
• O-Linked / Core 2 / Fuc(a1-2)Gal(b1-3)GlcNAc(b1-6)[Fuc(a1-2)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Fuc(a1-2)Gal(b1-4)GlcNAc(b1-6)[Fuc(a1-2)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-3)[GlcNAc(b1-6)]GalNAc
• O-Linked / Undefined core / GalNAc(?1-?)[NeuGc(?2-?)]Gal(?1-3)[GlcNAc(?1-6)]GalNAc
• O-Linked / Undefined core / Fuc(?1-2)Gal(?1-?)GlcNAc(?1-6)[NeuAc(?2-?)Gal(?1-3)]GalNAc
• O-Linked / Undefined core / Fuc(?1-2)Gal(?1-?)GlcNAc(?1-6)[NeuGc(?2-?)Gal(?1-3)]GalNAc

Composition

• HexNAc:1 (avg mass : 221.2103 )
• Hex:1 HexNAc:1 (avg mass : 383.3527 )
• Hex:1 HexNAc:1 NeuGc:1 (avg mass : 690.61 )
• Hex:1 HexNAc:1 NeuAc:1 (avg mass : 674.6106 )
• Hex:1 HexNAc:1 dHex:1 (avg mass : 529.4957 )
• Hex:1 HexNAc:2 (avg mass : 586.5477 )
• Hex:1 HexNAc:2 NeuGc:1 (avg mass : 893.805 )
• Hex:1 HexNAc:2 NeuAc:1 (avg mass : 877.8056 )
• Hex:1 HexNAc:2 dHex:1 (avg mass : 732.6907 )
• Hex:1 HexNAc:3 (avg mass : 789.7427 )
• Hex:1 HexNAc:3 NeuGc:1 (avg mass : 1097.0 )
• Hex:1 HexNAc:3 NeuAc:1 (avg mass : 1081.0006 )
• Hex:2 HexNAc:2 (avg mass : 748.6901 )
• Hex:2 HexNAc:2 dHex:1 (avg mass : 894.8331 )
• Hex:2 HexNAc:2 dHex:1 NeuGc:1 (avg mass : 1202.0904 )
• Hex:2 HexNAc:2 dHex:1 NeuAc:1 (avg mass : 1186.091 )
• Hex:2 HexNAc:2 dHex:2 (avg mass : 1040.9761 )

Disease

• Cystic Fibrosis (DOID:1485)
• Parasite Nippostrongylus brasiliensis infection

Reference

• Intestinal mucins from cystic fibrosis mice show increased fucosylation due to an induced Fucalpha1-2 glycosyltransferase. (2002 - Thomsson KA, Hinojosa-Kurtzberg M, Axelsson KA, Domino SE, Lowe JB, Gendler SJ, Hansson GC) / Status : Reviewed
• Identification of transient glycosylation alterations of sialylated mucin oligosaccharides during infection by the rat intestinal parasite Nippostrongylus brasiliensis. (2000 - Karlsson N, Olson F, Jovall P, Andersch Y, Enerbck L, Hansson G) / Status : Reviewed

Reported glycosite

• Muc2 / Mus musculus
  •        Undefined site
• Mucin / Rattus norvegicus
  •        Undefined site

Mass spectrometry observed peptide