Structure

Taxonomy

• Homo sapiens (Human)
• Bos taurus (Bovine)
• Mus musculus (House mouse)
• Rattus norvegicus (Norway rat)
• Gallus gallus (Chicken)
• Human cytomegalovirus (strain ad169)

Protein

• Keratin, type i cytoskeletal 18 / Homo sapiens    P05783
• Myc proto-oncogene protein / Homo sapiens    P01106
• Serum response factor (srf) / Homo sapiens    P11831
• Alpha crystallin - a and b chains / Bos taurus    P02470    P02510
• Alpha crystallin a chain (a1 subunit) / Bos taurus    P02470
• Alpha crystallin a chain (a2 subunit) / Bos taurus    P02470
• Estrogen receptor / Mus musculus    P19785
• Estrogen receptor beta / Mus musculus    O08537
• Neurofilament triplet l protein / Rattus norvegicus    P19527
• Neurofilament triplet m protein / Rattus norvegicus    P12839
• Talin / Gallus gallus    P54939
• Large structural phosphoprotein / Human cytomegalovirus (strain ad169)    P08318

Source

• Colon (UBERON_0001155)   HT-29 (CVCL_0320)  
• Gizzard Smooth Muscle (UBERON_0011903)  
• Lens of Camera-Type Eye (UBERON_0000965)  
• Ovary (UBERON_0000992)   Sf9 (CVCL_0549)  
• Prepuce of Penis (UBERON_0001332)   Fibroblast (CL_0000057)  
• Uterine Cervix (UBERON_0000002)   HeLa (CVCL_0030)  
• Neurofilament (GO_0005883)  

Reported structure

• O-Linked / Undefined core / GlcNAc

Composition

• HexNAc:1 (avg mass : 221.2103 )

Disease

• Adenocarcinoma, Grade II (DOID:299)
• Carcinoma (DOID:305)

Reference

• Alternative O-glycosylation/O-phosphorylation of the murine estrogen receptor beta. (2000 - Cheng X, Cole R, Zaia J, Hart G) / Status : Reviewed
• A subpopulation of estrogen receptors are modified by O-linked N-acetylglucosamine. (1997 - Jiang M, Hart G) / Status : Reviewed
• c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas. (1995 - Chou T, Hart G, Dang C) / Status : Reviewed
• Identification and mutational analysis of the glycosylation sites of human keratin 18. (1995 - Ku N, Omary M) / Status : Reviewed
• Site-specific glycosylation of the human cytomegalovirus tegument basic phosphoprotein (UL32) at serine 921 and serine 952. (1994 - Greis K, Gibson W, Hart G) / Status : Reviewed
• Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M. (1993 - Dong D, Xu Z, Chevrier M, Cotter R, Cleveland D, Hart G) / Status : Reviewed
• The cytoskeletal protein talin is O-glycosylated. (1992 - Hagmann J, Grob M, Burger M) / Status : Reviewed
• Vertebrate lens alpha-crystallins are modified by O-linked N-acetylglucosamine. (1992 - Roquemore E, Dell A, Morris H, Panico M, Reason A, Savoy L, Wistow G, Zigler J, Earles B, Hart G) / Status : Reviewed
• Identification of O-GlcNAc attachment sites in transcription factors. (1991 - Reason A, Dell A, Morris H, Panico M, Treisman R, Marais R, Hart G, Haltiwanger R) / Status : Reviewed
• Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18. (1991 - Chou C, Smith A, Omary M) / Status : Reviewed
• Bovine lens alpha-crystalline subunits are modified by O-linked GlcNAc. (1991 - Roquemore E, Dell A, Hart G) / Status : Reviewed
• Virion basic phosphoprotein from human cytomegalovirus contains O-linked N-acetylglucosamine. (1988 - Benko D, Haltiwanger R, Hart G, Gibson W) / Status : Reviewed

Reported glycosite

• Keratin, type i cytoskeletal 18 / Homo sapiens
  •        Ser-29
  •        Ser-30
  •        Ser-48
• Myc proto-oncogene protein / Homo sapiens
  •        Thr-58
• Serum response factor (srf) / Homo sapiens
  •        Ser-277
  •        Ser-316
• Alpha crystallin - a and b chains / Bos taurus
  •        Ser-162
• Alpha crystallin a chain (a1 subunit) / Bos taurus
  •        Ser-162
• Alpha crystallin a chain (a2 subunit) / Bos taurus
  •        Ser-162
• Estrogen receptor / Mus musculus
  •        Thr-575
• Estrogen receptor beta / Mus musculus
  •        Ser-61
• Neurofilament triplet l protein / Rattus norvegicus
  •        Thr-20
  •        Ser-26
• Neurofilament triplet m protein / Rattus norvegicus
  •        Thr-47
  •        Thr-430
• Talin / Gallus gallus
  •        Thr-18
  •        Thr-27
• Large structural phosphoprotein / Human cytomegalovirus (strain ad169)
  •        Ser-921
  •        Ser-952

Mass spectrometry observed peptide

GlcNAc

RES
1b:x-dglc-HEX-1:5
2s:n-acetyl
LIN
1:1d(2+1)2n