GlyConnect

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taxonomy (3) protein (8) source (9) structure (1) composition (1) disease (6) reference (13) site (8) peptide (0)

Taxonomy

Protein

Source

Reported structure

O-Linked / Core 2 / Fuc(a1-2)Gal(b1-3)[Gal(b1-4)GlcNAc(b1-6)]GalNAc

Composition

Hex:2 HexNAc:2 dHex:1 (avg mass : 894.8331 )

Disease

Reference

Colorectal cancer cell lines show striking diversity of their O-glycome reflecting the cellular differentiation phenotype (2021 - Katarina Madunić, Tao Zhang, Oleg A Mayboroda, Stephanie Holst, Kathrin Stavenhagen, Chunsheng Jin, Niclas G Karlsson, Guinevere S M Lageveen-Kammeijer, Manfred Wuhrer) / Status : Reviewed
Recombinant MUC1 probe authentically reflects cell-specific O-glycosylation profiles of endogenous breast cancer mucin. High density and prevalent core 2-based glycosylation. (2002 - Muller S, Hanisch FG) / Status : Reviewed
The broad diversity of neutral and sialylated oligosaccharides derived from human salivary mucins. (1992 - Klein A, Carnoy C, Wieruszeski J, Strecker G, Strang A, van Halbeek H, Roussel P, Lamblin G) / Status : Reviewed
Neutral oligosaccharides of bovine submaxillary mucin. A combined mass spectrometry and 1H-NMR study. (1992 - Chai W, Hounsell E, Cashmore G, Rosankiewicz J, Bauer C, Feeney J, Feizi T, Lawson A) / Status : Reviewed
Quantitation and structures of oligosaccharide chains in human trachea mucin glycoproteins. (1992 - Sangadala S, Bhat U, Mendicino J) / Status : Reviewed
Characterisation of minor tetra- to hepta-saccharides O-linked to human meconium glycoproteins by t.l.c.-m.s. microsequencing of neoglycolipid derivatives in conjunction with conventional m.s. and 1H-n.m.r. spectroscopy. (1991 - Lawson A, Hounsell E, Stoll M, Feeney J, Chai W, Rosankiewicz J, Feizi T) / Status : Reviewed
Structures of O-glycosidically linked oligosaccharides isolated from human meconium glycoproteins. (1989 - Capon C, Leroy Y, Wieruszeski J, Ricart G, Strecker G, Montreuil J, Fournet B) / Status : Reviewed
Primary structure of twenty three neutral and monosialylated oligosaccharides O-glycosidically linked to the human secretory immunoglobulin A hinge region determined by a combination of permethylation analysis and 400-MHz 1H-NMR spectroscopy. (1989 - Pierce-Cretel A, Decottignies J, Wieruszeski J, Strecker G, Montreuil J, Spik G) / Status : Reviewed
Primary structure of neutral oligosaccharides derived from respiratory-mucus glycoproteins of a patient suffering from bronchiectasis, determined by combination of 500-MHz 1H-NMR spectroscopy and quantitative sugar analysis. 1. Structure of 16 oligosaccharides having the Gal beta(1---3)GalNAc-ol cor (1988 - Klein A, Lamblin G, Lhermitte M, Roussel P, Breg J, Van Halbeek H, Vliegenthart J) / Status : Reviewed
Further characterization, by a combined high-performance liquid chromatography/1H-NMR approach, of the heterogeneity displayed by the neutral carbohydrate chains of human bronchial mucins. (1984 - Lamblin G, Boersma A, Lhermitte M, Roussel P, Mutsaers J, van Halbeek H, Vliegenthart J) / Status : Reviewed
The combination of normal-phase and reverse-phase high-pressure liquid chromatography with NMR for the isolation and characterization of oligosaccharide alditols from ovarian cyst mucins. (1984 - Dua V, Dube V, Bush C) / Status : Reviewed
Immunochemical studies on blood groups. Structures and immunochemical properties of oligosaccharides from two fractions of blood group substance from human ovarian cyst fluid differing in B, I, and i activities and reactivity toward concanavalin A. (1976 - Maisonrouge-McAuliffe F, Kabat E) / Status : Reviewed
Immunochemical studies on blood groups. Immunochemical properties of B-active and non-B-active blood group substances from horse gastric mucosae and the relative size distributions of oligosaccharides liberated by base-borohydride. (1976 - Newman W, Kabat E) / Status : Reviewed

Reported glycosite

Glycoprotein ln / Homo sapiens
- Undefined site
Immunoglobulin heavy constant alpha 1 / Homo sapiens
- Undefined site
Muc1 fusion protein / Homo sapiens
- Undefined site
Uncharacterized protein from Meconium / Homo sapiens
- Undefined site
Uncharacterized protein from Ovary / Homo sapiens
- Undefined site
Unspecified mucin / Homo sapiens
- Undefined site
Mucin / Bos taurus
- Undefined site
Mucin / Equus caballus
- Undefined site

Mass spectrometry observed peptide

- O-Linked / Core 2 (avg mass : 894.8331)

3D structure from GLYCAM

Cross-references

GlyTouCan : G94514IB

GlyGen : G94514IB

ChEBI : 155152

UniCarb-DB :

Composition

Hex:2 HexNAc:2 dHex:1

IUPAC

Fuc(a1-2)Gal(b1-3)[Gal(b1-4)GlcNAc(b1-6)]GalNAc

GlycoCT

RES
1b:a-dgal-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:a-lgal-HEX-1:5|6:d
5b:b-dglc-HEX-1:5
6s:n-acetyl
7b:b-dgal-HEX-1:5
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:3o(2+1)4d
4:1o(6+1)5d
5:5d(2+1)6n
6:5o(4+1)7d

GWS

freeEnd--?a1D-GalNAc,p(--3b1D-Gal,p--2a1L-Fuc,p)--6b1D-GlcNAc,p--4b1D-Gal,p$MONO,Und,0,0,freeEnd

Glycam

LFucpa1-2DGalpb1-3[DGalpb1-4DGlcpNAcb1-6]DGalpNAca1-OH

SMILES

C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O[C@@H]2[C@H]([C@H]([C@H](O[C@H]2O[C@@H]3[C@H]([C@H](O[C@@H]([C@@H]3O)CO[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O[C@H]5[C@@H]([C@H]([C@H]([C@H](O5)CO)O)O)O)O)NC(=O)C)O)NC(=O)C)CO)O)O)O)O)O

InCHI key

RDOQVZSBOIGGIF-OQDAOTKMSA-N

InCHI

InChI=1S/C34H58N2O25/c1-8-17(42)22(47)25(50)32(54-8)61-29-24(49)19(44)12(5-38)57-34(29)60-28-16(36-10(3)41)30(52)55-14(20(28)45)7-53-31-15(35-9(2)40)21(46)27(13(6-39)58-31)59-33-26(51)23(48)18(43)11(4-37)56-33/h8,11-34,37-39,42-52H,4-7H2,1-3H3,(H,35,40)(H,36,41)/t8-,11+,12+,13+,14+,15+,16+,17+,18-,19-,20-,21+,22+,23-,24-,25-,26+,27+,28+,29+,30-,31+,32-,33-,34-/m0/s1