GlyConnect

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taxonomy (15) protein (36) source (38) structure (1) composition (1) disease (14) reference (47) site (41) peptide (0)

Taxonomy

Protein

Source

Reported structure

O-Linked / Core 1 / Gal(b1-3)[NeuAc(a2-6)]GalNAc

Composition

Hex:1 HexNAc:1 NeuAc:1 (avg mass : 674.6106 )

Disease

Reference

Glycoproteome remodeling in MLL-rearranged B-cell precursor acute lymphoblastic leukemia. (2021 - Oliveira T, Zhang M, Joo EJ, Abdel-Azim H, Chen CW, Yang L, Chou CH, Qin X, Chen J, Alagesan K, Almeida A, Jacob F, Packer NH, von Itzstein M, Heisterkamp N, Kolarich D) / Status : Reviewed
Colorectal cancer cell lines show striking diversity of their O-glycome reflecting the cellular differentiation phenotype (2021 - Katarina Madunić, Tao Zhang, Oleg A Mayboroda, Stephanie Holst, Kathrin Stavenhagen, Chunsheng Jin, Niclas G Karlsson, Guinevere S M Lageveen-Kammeijer, Manfred Wuhrer) / Status : Reviewed
The O-Glycome of Human Nigrostriatal Tissue and Its Alteration in Parkinson's Disease. (2021 - Wilkinson H, Thomsson KA, Rebelo AL, Hilliard M, Pandit A, Rudd PM, Karlsson NG, Saldova R.) / Status : Unreviewed
Bisecting GlcNAc Protein N-Glycosylation Is Characteristic of Human Adipogenesis. (2020 - Katherine Wongtrakul-Kish, Benjamin R Herbert, Nicolle H Packer) / Status : Reviewed
The Glycosylation of Human Serum IgD and IgE and the Accessibility of Identified Oligomannose Structures for Interaction with Mannan-Binding Lectin (2004 - James N. Arnold, Catherine M. Radcliffe, Mark R. Wormald, Louise Royle, David J. Harvey, Max Crispin, Raymond A. Dwek, Robert B. Sim and Pauline M. Rudd) / Status : Reviewed
Identification of the blood group Lewis(a) determinant in the oviducal mucins of Xenopus tropicalis. (2003 - Guérardel Y, Petit D, Madigou T, Guillet B, Maes E, Maftah A, Boujard D, Strecker G, Kol O) / Status : Reviewed
Species-specificity of amphibia carbohydrate chains: the Bufo viridis case study (2002 - Coppin, Maes, Strecker) / Status : Reviewed
Recombinant MUC1 probe authentically reflects cell-specific O-glycosylation profiles of endogenous breast cancer mucin. High density and prevalent core 2-based glycosylation. (2002 - Muller S, Hanisch FG) / Status : Reviewed
O-glycan analysis of natural human neutrophil gelatinase B using a combination of normal phase-HPLC and online tandem mass spectrometry: implications for the domain organization of the enzyme. (2000 - Mattu T, Royle L, Langridge J, Wormald M, Van den Steen P, Van Damme J, Opdenakker G, Harvey D, Dwek R, Rudd P) / Status : Reviewed
High prevalence of 2-mono- and 2,6-di-substituted manol-terminating sequences among O-glycans released from brain glycopeptides by reductive alkaline hydrolysis. (1999 - Chai W, Yuen C, Kogelberg H, Carruthers R, Margolis R, Feizi T, Lawson A) / Status : Reviewed
Purification and characterization of the MUC1 mucin-type glycoprotein, epitectin, from human urine: structures of the major oligosaccharide alditols. (1998 - Bhavanandan V, Zhu Q, Yamakami K, Dilulio N, Nair S, Capon C, Lemoine J, Fournet B) / Status : Reviewed
Structural study of the O-linked sugar chains of human leukocyte tyrosine phosphatase CD45. (1998 - Furukawa K, Funakoshi Y, Autero M, Horejsi V, Kobata A, Gahmberg C) / Status : Reviewed
Structural analysis of oligosaccharide-alditols released by reductive beta-elimination from oviducal mucins of Rana dalmatina. (1998 - Morelle W, Guytant R, Strecker G) / Status : Reviewed
The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fc alpha receptor interactions. (1998 - Mattu T, Pleass R, Willis A, Kilian M, Wormald M, Lellouch A, Rudd P, Woof J, Dwek R) / Status : Reviewed
Structural characterisation of N-linked and O-linked oligosaccharides derived from interferon-alpha2b and interferon-alpha14c produced by Sendai-virus-induced human peripheral blood leukocytes (1998 - Nyman, Kalkkinen, Tolo, Helin) / Status : Reviewed
Structural analysis of oligosaccharide-alditols released by reductive beta-elimination from the jelly coats of the anuran Bufo arenarum. (1998 - Morelle W, Cabada M, Strecker G) / Status : Reviewed
Structural analysis of oligosaccharide-alditols released by reductive beta-elimination from oviducal mucins of Bufo bufo: characterization of the carbohydrate sequence Gal(alpha1-3)GalNAc(alpha1-3)[Fuc(alpha1-2)]Gal. (1997 - Morelle W, Strecker G) / Status : Reviewed
Structure of the O-linked oligosaccharides from a major thyroid cell surface glycoprotein. (1997 - Edge A, Spiro R) / Status : Reviewed
O-glycosylated species of natural human tumor-necrosis factor-alpha. (1996 - Takakura-Yamamoto R, Yamamoto S, Fukuda S, Kurimoto M) / Status : Reviewed
Structures of monosialyl oligosaccharides isolated from the respiratory mucins of a non-secretor (O, Lea+b-) patient suffering from chronic bronchitis. Characterization of a novel type of mucin carbohydrate core structure. (1994 - van Halbeek H, Strang A, Lhermitte M, Rahmoune H, Lamblin G, Roussel P) / Status : Reviewed
Isolation, structural determination, and calcium-binding properties of the major glycoprotein present in Bufo japonicus japonicus egg jelly. (1994 - Shimoda Y, Kitajima K, Inoue S, Inoue Y) / Status : Reviewed
An improved approach to the analysis of the structure of small oligosaccharides of glycoproteins: application to the O-linked oligosaccharides from human glycophorin A. (1993 - Krotkiewski H, Lisowska E, Nilsson G, Grnberg G, Nilsson B) / Status : Reviewed
Structures of mucin-type sugar chains on human erythropoietins purified from urine and the culture medium of recombinant Chinese hamster ovary cells. (1993 - Inoue N, Takeuchi M, Asano K, Shimizu R, Takasaki S, Kobata A) / Status : Reviewed
The broad diversity of neutral and sialylated oligosaccharides derived from human salivary mucins. (1992 - Klein A, Carnoy C, Wieruszeski J, Strecker G, Strang A, van Halbeek H, Roussel P, Lamblin G) / Status : Reviewed
1H and 13C-NMR assignments for sialylated oligosaccharide-alditols related to mucins. Study of thirteen components from hen ovomucin and swallow nest mucin. (1992 - Strecker G, Wieruszeski J, Cuvillier O, Michalski J, Montreuil J) / Status : Reviewed
Structure determination of five sialylated trisaccharides with core types 1, 3 or 5 isolated from bovine submaxillary mucin. (1990 - Savage A, Donoghue C, D'Arcy S, Koeleman C, van den Eijnden D) / Status : Reviewed
Analysis of N- and O-glycosidically bound sialooligosaccharides in glycoproteins by high-performance liquid chromatography with pulsed amperometric detection. (1990 - Honda S, Suzuki S, Zaiki S, Kakehi K) / Status : Reviewed
Structures of O-glycosidically linked oligosaccharides isolated from human meconium glycoproteins. (1989 - Capon C, Leroy Y, Wieruszeski J, Ricart G, Strecker G, Montreuil J, Fournet B) / Status : Reviewed
Isolation and structural characterization of low-molecular-mass monosialyl oligosaccharides derived from respiratory-mucus glycoproteins of a patient suffering from bronchiectasis. (1988 - van Halbeek H, Breg J, Vliegenthart J, Klein A, Lamblin G, Roussel P) / Status : Reviewed
Comparative study of the mucin-type sugar chains of human chorionic gonadotropin present in the urine of patients with trophoblastic diseases and healthy pregnant women. (1988 - Amano J, Nishimura R, Mochizuki M, Kobata A) / Status : Reviewed
Structure of sialyloligosaccharides isolated from bonnet monkey (Macaca radiata) cervical mucus glycoproteins exhibiting multiple blood group activities. (1986 - Nasir-Ud-Din , Jeanloz R, Lamblin G, Roussel P, van Halbeek H, Mutsaers J, Vliegenthart J) / Status : Reviewed
Structures of O-linked oligosaccharides present in the proteoglycans secreted by human mammary epithelial cells. (1986 - Gowda D, Bhavanandan V, Davidson E) / Status : Reviewed
Characterization of O-glycosidically linked oligosaccharides of rat erythrocyte membrane sialoglycoproteins. (1986 - Edge A, Van Langenhove A, Reinhold V, Weber P) / Status : Reviewed
Carbohydrate structures of bovine submaxillary mucin. (1986 - Tsuji T, Osawa T) / Status : Reviewed
Porcine submaxillary mucin contains alpha 2----3- and alpha 2----6-linked N-acetyl- and N-glycolylneuraminic acid. (1986 - Savage A, Koppen P, Schiphorst W, Trippelvitz L, Van Halbeek H, Vliegenthart J, Van den Eijnden D) / Status : Reviewed
Structures of O-linked oligosaccharides isolated from normal granulocytes, chronic myelogenous leukemia cells, and acute myelogenous leukemia cells. (1986 - Fukuda M, Carlsson S, Klock J, Dell A) / Status : Reviewed
Structural variations of O-linked oligosaccharides present in leukosialin isolated from erythroid, myeloid, and T-lymphoid cell lines. (1986 - Carlsson S, Sasaki H, Fukuda M) / Status : Reviewed
Structures of the carbohydrate units of polysialoglycoproteins isolated from the eggs of four species of salmonid fishes. (1985 - Iwasaki M, Inoue S) / Status : Reviewed
Structural studies of O-glycosidic oligosaccharide units of dog erythrocyte glycophorin. (1985 - Yamashita T, Murayama J, Utsumi H, Hamada A) / Status : Reviewed
Purification and structures of oligosaccharide chains in swine trachea and Cowper's gland mucin glycoproteins. (1984 - Rana SS, Chandrasekaran EV, Kennedy J, Mendicino J) / Status : Reviewed
Structures of the O-glycosidically linked oligosaccharides of human IgD. (1983 - S J Mellis, J U Baenziger) / Status : Reviewed
Study of the carbohydrate moiety of human serum sex hormone-binding globulin. (1983 - Avvakumov G, Matveentseva I, Akhrem L, Strel'chyonok O, Akhrem A) / Status : Reviewed
Structures of the major oligosaccharides from a human rectal adenocarcinoma glycoprotein. (1983 - Kurosaka A, Nakajima H, Funakoshi I, Matsuyama M, Nagayo T, Yamashina I) / Status : Reviewed
Structures of the O-glycosidically linked oligosaccharides of human IgD. (1983 - Mellis S, Baenziger J) / Status : Reviewed
The structures of the carbohydrate moieties of bovine blood coagulation factor X. (1980 - Mizuochi T, Yamashita K, Fujikawa K, Titani K, Kobata A) / Status : Reviewed
A 360-MHz 1H-NMR study of three oligosaccharides isolated from cow kappa-casein. (1980 - van Halbeek H, Dorland L, Vliegenthart J, Fiat A, Jolles P) / Status : Reviewed
Isolation and characterization of oligosaccharides from canine submaxillary mucin. (1974 - Lombart C, Winzler R) / Status : Reviewed

Reported glycosite

Choriogonadotropin - alpha and beta chains / Homo sapiens
- Undefined site
Erythropoietin / Homo sapiens
- Undefined site
Glycophorin-A / Homo sapiens
- Undefined site
Immunoglobulin heavy constant alpha 1 / Homo sapiens
- Undefined site
Immunoglobulin heavy constant delta / Homo sapiens
- Undefined site
- Ser-109
- Thr-126
- Thr-127
- Thr-131
- Thr-132
Immunoglobulin heavy variable 4-39 / Homo sapiens
- Undefined site
Interferon alpha-2 / Homo sapiens
- Thr-129
Leukosialin (cd43) / Homo sapiens
- Undefined site
Matrix metalloproteinase-9 / Homo sapiens
- Undefined site
Muc1 fusion protein / Homo sapiens
- Undefined site
Mucin-1 / Homo sapiens
- Undefined site
Proteoglycan / Homo sapiens
- Undefined site
Receptor-type tyrosine-protein phosphatase C / Homo sapiens
- Undefined site
Rgm / Homo sapiens
- Undefined site
Sex hormone-binding globulin / Homo sapiens
- Thr-36
Tumor-necrosis factor-alpha / Homo sapiens
- Ser-80
Uncharacterized protein / Homo sapiens
- Undefined site
Unspecified mucin / Homo sapiens
- Undefined site
Coagulation factor x / Bos taurus
- Undefined site
Gp-3 / Bos taurus
- Undefined site
Kappa casein / Bos taurus
- Undefined site
Mucin / Bos taurus
- Undefined site
Glycophorin / Canis lupus familiaris
- Undefined site
Mucin / Canis lupus familiaris
- Undefined site
Mucin / Macaca radiata
- Undefined site
Brain non dialyzable glycopeptide / Oryctolagus cuniculus
- Undefined site
Sialoglycoprotein (rspg-4) / Rattus norvegicus
- Undefined site
Mucin / Sus scrofa
- Undefined site
Polysialoglycoprotein (psgp) / Salvelinus leucomaenis pluvius
- Undefined site
Mucin / Bufo arenarum
- Undefined site
Mucin / Bufo bufo
- Undefined site
Uncharacterized protein / Bufo japonicus
- Undefined site
Mucin / Bufo viridis
- Undefined site
Mucin / Rana dalmatina
- Undefined site
Mucin / Xenopus tropicalis
- Undefined site
Ovomucin / Gallus gallus
- Undefined site

Mass spectrometry observed peptide

- O-Linked / Core 1 (avg mass : 674.6106)

3D structure from GLYCAM

Cross-references

GlyTouCan : G56682BC

GlyGen : G56682BC

ChEBI : 63233

UniCarb-DB :

Composition

Hex:1 HexNAc:1 NeuAc:1

IUPAC

Gal(b1-3)[NeuAc(a2-6)]GalNAc

GlycoCT

RES
1b:a-dgal-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
5s:n-acetyl
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:1o(6+2)4d
4:4d(5+1)5n

GWS

freeEnd--?a1D-GalNAc,p(--3b1D-Gal,p)--6a2D-NeuAc,p$MONO,Und,0,0,freeEnd

SMILES

CC(=O)N[C@@H]1[C@H](C[C@@](O[C@H]1[C@@H]([C@@H](CO)O)O)(C(=O)O)OC[C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)O)NC(=O)C)O[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)O)O)O

InCHI key

WGMXQFVVADPLGR-KAISWPRVSA-N

InCHI

InChI=1S/C25H42N2O19/c1-7(30)26-13-9(32)3-25(24(40)41,46-21(13)15(34)10(33)4-28)42-6-12-17(36)20(14(22(39)43-12)27-8(2)31)45-23-19(38)18(37)16(35)11(5-29)44-23/h9-23,28-29,32-39H,3-6H2,1-2H3,(H,26,30)(H,27,31)(H,40,41)/t9-,10+,11+,12+,13+,14+,15+,16-,17-,18-,19+,20+,21+,22-,23-,25+/m0/s1