Structure

Glycan references

GlyTouCan : G80858MF

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Composition

Hex:3 HexNAc:4 dHex:1

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IUPAC

GlcNAc(b1-2)Man(a1-3)[GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc

GlycoCT

RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:b-dglc-HEX-1:5
4s:n-acetyl
5b:b-dman-HEX-1:5
6b:a-dman-HEX-1:5
7b:b-dglc-HEX-1:5
8s:n-acetyl
9b:a-dman-HEX-1:5
10b:b-dglc-HEX-1:5
11s:n-acetyl
12b:a-lgal-HEX-1:5|6:d
LIN
1:1d(2+1)2n
2:1o(4+1)3d
3:3d(2+1)4n
4:3o(4+1)5d
5:5o(3+1)6d
6:6o(2+1)7d
7:7d(2+1)8n
8:5o(6+1)9d
9:9o(2+1)10d
10:10d(2+1)11n
11:1o(6+1)12d

References (38)

Structural studies on IgG oligosaccharides of patients with primary Sjogren's syndrome. (2002)
Kuroda Y, Nakata M, Makino A, Matsumoto A, Ohashi K, Itahashi K, Takeuchi F, Goto M, Kojima N, Mizuochi T
Pubmed : 12652077  
Status : Reviewed

Localization of N-linked carbohydrate chains in glycoprotein ZPA of the bovine egg zona pellucida. (2002)
Ikeda K, Yonezawa N, Naoi K, Katsumata T, Hamano S, Nakano M
Pubmed : 12199704  
Status : Reviewed

A comparative study of the asparagine-linked oligosaccharides on siglec-5, siglec-7 and siglec-8, expressed in a CHO cell line, and their contribution to ligand recognition (2001)
Freeman, Birrell, D Alessio, Erickson-Miller, Kikly, Camilleri
Pubmed : 11231274  
Status : Reviewed

Sialylation of human IgG-Fc carbohydrate by transfected rat alpha2,6-sialyltransferase (2001)
Jassal, Jenkins, Charlwood, Camilleri, Jefferis, Lund
Pubmed : 11500028   DOI : 10.1006/bbrc.2001.5382
Status : Reviewed

Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells (2001)
Khandekar, Silverman, Wells-Marani, Bacon, Birrell, Brigham-Burke, DeMarini, Jonak, Camilleri, Fishman-Lobell
Pubmed : 11676606   DOI : 10.1006/prep.2001.1501
Status : Reviewed

Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines. (2001)
Charlwood J, Dingwall C, Matico R, Hussain I, Johanson K, Moore S, Powell DJ, Skehel JM, Ratcliffe S, Clarke B, Trill J, Sweitzer S, Camilleri P
Pubmed : 11278492   DOI : 10.1074/jbc.M009361200
Status : Reviewed

Identification of core alpha 1,3-fucosylated glycans and cloning of the requisite fucosyltransferase cDNA from Drosophila melanogaster. Potential basis of the neural anti-horseradish peroxidase epitope. (2001)
Fabini G, Freilinger A, Altmann F, Wilson I
Pubmed : 11382750   DOI : 10.1074/jbc.M100573200
Status : Reviewed

In vivo trafficking and catabolism of IgG1 antibodies with Fc associated carbohydrates of differing structure. (2000)
Wright A, Sato Y, Okada T, Chang K, Endo T, Morrison S
Pubmed : 11159927  
Status : Reviewed

N-linked oligosaccharide structures in the diamine oxidase from porcine kidney. (2000)
Huang Y, Mechref Y, Novotny M
Pubmed : 10782293  
Status : Reviewed

Remodeling of sugar chain structures of human interferon-gamma. (2000)
Fukuta K, Abe R, Yokomatsu T, Kono N, Asanagi M, Omae F, Minowa M, Takeuchi M, Makino T
Pubmed : 10764830  
Status : Reviewed

Oligosaccharide analysis and molecular modeling of soluble forms of glycoproteins belonging to the Ly-6, scavenger receptor, and immunoglobulin superfamilies expressed in Chinese hamster ovary cells. (1999)
Rudd P, Wormald M, Harvey D, Devasahayam M, McAlister M, Brown M, Davis S, Barclay A, Dwek R
Pubmed : 10207177  
Status : Reviewed

Glycosylation of a CNS-specific extracellular matrix glycoprotein, tenascin-R, is dominated by O-linked sialylated glycans and "brain-type" neutral N-glycans. (1999)
Zamze S, Harvey D, Pesheva P, Mattu T, Schachner M, Dwek R, Wing D
Pubmed : 10406848  
Status : Reviewed

Differential N-glycan patterns of secreted and intracellular IgG produced in Trichoplusia ni cells. (1997)
Hsu T, Takahashi N, Tsukamoto Y, Kato K, Shimada I, Masuda K, Whiteley E, Fan J, Lee Y, Betenbaugh M
Pubmed : 9083032  
Status : Reviewed

Multiple interactions of IgG with its core oligosaccharide can modulate recognition by complement and human Fc gamma recpetor I and influence the synthesis of its oligosaccharide chains (1996)
Lund, Takahashi, Pound, Goodall, Jefferis
Pubmed : 8943402  
Status : Reviewed

Elucidation of N-linked oligosaccharide structures of recombinant human factor VIII using fluorophore-assisted carbohydrate electrophoresis. (1996)
Kumar H, Hague C, Haley T, Starr C, Besman M, Lundblad R, Baker D
Pubmed : 8969451  
Status : Reviewed

Structural characterization of the N-linked carbohydrate chains of the zona pellucida glycoproteins from bovine ovarian and fertilized eggs. (1996)
Katsumata T, Noguchi S, Yonezawa N, Tanokura M, Nakano M
Pubmed : 8841411  
Status : Reviewed

Comparative study of the sugar chains of alkaline phosphatases purified from rat liver and rat AH-130 hepatoma cells. Occurrence of fucosylated high-mannose-type and hybrid-type sugar chains. (1996)
Endo T, Fujiwara T, Ikehara Y, Kobata A
Pubmed : 8612632  
Status : Reviewed

Identification of neutral and sialyl N-linked oligosaccharide structures from human serum glycoproteins using three kinds of high-performance liquid chromatography. (1995)
Nakagawa H, Kawamura Y, Kato K, Shimada I, Arata Y, Takahashi N
Pubmed : 7785764   DOI : 10.1006/abio.1995.1200
Status : Reviewed

Structural analysis of the oligosaccharides derived from glycodelin, a human glycoprotein with potent immunosuppressive and contraceptive activities. (1995)
Dell A, Morris H, Easton R, Panico M, Patankar M, Oehniger S, Koistinen R, Koistinen H, Seppala M, Clark G
Pubmed : 7592613  
Status : Reviewed

Structural characterization of the N-glycans of a humanized anti-CD18 murine immunoglobulin G. (1994)
Ip C, Miller W, Silberklang M, Mark G, Ellis R, Huang L, Glushka J, Van Halbeek H, Zhu J, Alhadeff J
Pubmed : 7906504  
Status : Reviewed

Structural changes in the N-linked sugar chains of serum immunoglobulin G of HTLV-I transgenic mice. (1993)
Endo T, Iwakura Y, Kobata A
Pubmed : 8507175   DOI : 10.1006/bbrc.1993.1516
Status : Reviewed

Structural study of the oligosaccharide moieties of sphingolipid activator proteins, saposins A, C and D obtained from the spleen of a Gaucher patient. (1993)
Ito K, Takahashi N, Takahashi A, Shimada I, Arata Y, O'Brien J, Kishimoto Y
Pubmed : 8344278  
Status : Reviewed

Control of IgG/Fc glycosylation: a comparison of oligosaccharides from chimeric human/mouse and mouse subclass immunoglobulin Gs. (1993)
Lund J, Takahashi N, Nakagawa H, Goodall M, Bentley T, Hindley S, Tyler R, Jefferis R
Pubmed : 8502242  
Status : Reviewed

Characterization of E-PHA-reactive alpha-fetoprotein isoforms by two-dimensional lectin affinity electrophoresis. (1993)
Taketa K, Fujii Y, Taga H
Pubmed : 7511099  
Status : Reviewed

A simple method for the release of asparagine-linked oligosaccharides from a glycoprotein purified by SDS-polyacrylamide gel electrophoresis. (1992)
Kawashima H, Murata T, Yamamoto K, Tateishi A, Irimura T, Osawa T
Pubmed : 1639758  
Status : Reviewed

Detailed structural analysis of asparagine-linked oligosaccharides of the nicotinic acetylcholine receptor from Torpedo californica. (1992)
Shoji H, Takahashi N, Nomoto H, Ishikawa M, Shimada I, Arata Y, Hayashi K
Pubmed : 1633814  
Status : Reviewed

Structural study of the sugar moieties of monoclonal antibodies secreted by human-mouse hybridoma. (1991)
Tandai M, Endo T, Sasaki S, Masuho Y, Kochibe N, Kobata A
Pubmed : 1952948  
Status : Reviewed

Neutral oligosaccharide structures linked to asparagines of porcine zona pellucida glycoproteins. (1991)
Mori E, Takasaki S, Hedrick J, Wardrip N, Mori T, Kobata A
Pubmed : 1998670  
Status : Reviewed

Oligosaccharide structures present on asparagine-289 of recombinant human plasminogen expressed in a Chinese hamster ovary cell line. (1991)
Davidson D, Castellino F
Pubmed : 1899031  
Status : Reviewed

Bovine glomerular basement membrane. Location and structure of the asparagine-linked oligosaccharide units and their potential role in the assembly of the 7 S collagen IV tetramer. (1991)
Langeveld J, Noelken M, Hrd K, Todd P, Vliegenthart J, Rouse J, Hudson B
Pubmed : 1990011  
Status : Reviewed

Carbohydrate structure of human pancreatic elastase 1. (1991)
Wendorf P, Linder D, Sziegoleit A, Geyer R
Pubmed : 1898343  
Status : Reviewed

A comparative study of the N-linked oligosaccharide structures of human IgG subclass proteins. (1990)
Jefferis R, Lund J, Mizutani H, Nakagawa H, Kawazoe Y, Arata Y, Takahashi N
Pubmed : 2363690  
Status : Reviewed

The carbohydrate structures of a mouse monoclonal IgG antibody OKT3. (1990)
Krotkiewski H, Grnberg G, Krotkiewska B, Nilsson B, Svensson S
Pubmed : 2122971  
Status : Reviewed

The polypeptide of immunoglobulin G influences its galactosylation in vivo. (1990)
Lee S, Connolly J, Ramirez-Soto D, Poretz R
Pubmed : 2108149  
Status : Reviewed

Structural heterogeneity of sugar chains in immunoglobulin G. Conformation of immunoglobulin G molecule and substrate specificities of glycosyltransferases. (1990)
Fujii S, Nishiura T, Nishikawa A, Miura R, Taniguchi N
Pubmed : 2138613  
Status : Reviewed

A protein structural change in aglycosylated IgG3 correlates with loss of huFc gamma R1 and huFc gamma R111 binding and/or activation. (1990)
Lund J, Tanaka T, Takahashi N, Sarmay G, Arata Y, Jefferis R
Pubmed : 2174119  
Status : Reviewed

Comparative structural study of the N-linked oligosaccharides of human normal and pathological immunoglobulin G. (1987)
Takahashi N, Ishii I, Ishihara H, Mori M, Tejima S, Jefferis R, Endo S, Arata Y
Pubmed : 3567160  
Status : Reviewed

Structures of the sugar chains of rabbit immunoglobulin G: occurrence of asparagine-linked sugar chains in Fab fragment. (1985)
Taniguchi T, Mizuochi T, Beale M, Dwek R, Rademacher T, Kobata A
Pubmed : 4074713  
Status : Reviewed