Structure

Taxonomy

• Homo sapiens (Human)

Protein

• Erythropoietin / Homo sapiens    P01588
• Low-density lipoprotein receptor / Homo sapiens    P01130
• Proteoglycan 4 (lubricin) / Homo sapiens    Q92954

Source

• Skin of Body (UBERON_0002097)   Fibroblast (CL_0000057)  
• Synovial Fluid (UBERON_0001090)  

Reported structure

• O-Linked / Undefined core / GlcNAc(?1-?)GalNAc

Composition

• HexNAc:2 (avg mass : 424.4053 )

Disease

• Arthritis, Rheumatoid (DOID:7148)
• Osteoarthritis (DOID:8398)

Reference

• The O-glycomap of lubricin, a novel mucin responsible for joint lubrication, identified by site-specific glycopeptide analysis (2014 - Ali L, Flowers SA, Jin C, Bennet EP, Ekwall AK, Karlsson NG) / Status : Reviewed
• Determination of site-specific glycan heterogeneity on glycoproteins (2012 - Kolarich D1, Jensen PH, Altmann F, Packer NH.) / Status : Reviewed
• Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor. (1983 - Cummings R, Kornfeld S, Schneider W, Hobgood K, Tolleshaug H, Brown M, Goldstein J) / Status : Reviewed

Reported glycosite

• Erythropoietin / Homo sapiens
  •        Ser-153
• Low-density lipoprotein receptor / Homo sapiens
  •        Undefined site
• Proteoglycan 4 (lubricin) / Homo sapiens
  •        Ser-553
  •        Thr-555
  •        Thr-1161

Mass spectrometry observed peptide

GlcNAc(?1-?)GalNAc

RES
1b:a-dgal-HEX-1:5
2b:x-dglc-HEX-1:5
3s:n-acetyl
4s:n-acetyl
LIN
1:1o(-1+1)2d
2:2d(2+1)3n
3:1d(2+1)4n