GlyConnect

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taxonomy (6) protein (14) source (38) structure (1) composition (1) disease (17) reference (18) site (14) peptide (0)

Taxonomy

Protein

Source

Reported structure

O-Linked / Core 2 / NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc

Composition

Hex:2 HexNAc:2 NeuAc:1 (avg mass : 1039.948 )

Disease

Reference

Colorectal cancer cell lines show striking diversity of their O-glycome reflecting the cellular differentiation phenotype (2021 - Katarina Madunić, Tao Zhang, Oleg A Mayboroda, Stephanie Holst, Kathrin Stavenhagen, Chunsheng Jin, Niclas G Karlsson, Guinevere S M Lageveen-Kammeijer, Manfred Wuhrer) / Status : Unreviewed
Glycoproteome remodeling in MLL-rearranged B-cell precursor acute lymphoblastic leukemia. (2021 - Oliveira T, Zhang M, Joo EJ, Abdel-Azim H, Chen CW, Yang L, Chou CH, Qin X, Chen J, Alagesan K, Almeida A, Jacob F, Packer NH, von Itzstein M, Heisterkamp N, Kolarich D) / Status : Reviewed
Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor (2020 - Peng Zhao, Jeremy L. Praissman, Oliver C. Grant, Yongfei Cai, Tianshu Xiao, Katelyn E. Rosenbalm, Kazuhiro Aoki, Benjamin P. Kellman, Robert Bridger, Dan H. Barouch, Melinda A. Brindley, Nathan E. Lewis, Michael Tiemeyer, Bing Chen, Robert J. Woods, Lance Wells) / Status : Reviewed
Murine and human zona pellucida 3 derived from mouse eggs express identical O-glycans. (2003 - Dell A, Chalabi S, Easton RL, Haslam SM, Sutton-Smith M, Patankar MS, Lattanzio F, Panico M, Morris HR, Clark GF) / Status : Reviewed
Recombinant MUC1 probe authentically reflects cell-specific O-glycosylation profiles of endogenous breast cancer mucin. High density and prevalent core 2-based glycosylation. (2002 - Muller S, Hanisch FG) / Status : Reviewed
High prevalence of 2-mono- and 2,6-di-substituted manol-terminating sequences among O-glycans released from brain glycopeptides by reductive alkaline hydrolysis. (1999 - Chai W, Yuen C, Kogelberg H, Carruthers R, Margolis R, Feizi T, Lawson A) / Status : Reviewed
Sialylation and sulfation of the carbohydrate chains in respiratory mucins from a patient with cystic fibrosis. (1994 - Lo-Guidice J, Wieruszeski J, Lemoine J, Verbert A, Roussel P, Lamblin G) / Status : Reviewed
Structures of monosialyl oligosaccharides isolated from the respiratory mucins of a non-secretor (O, Lea+b-) patient suffering from chronic bronchitis. Characterization of a novel type of mucin carbohydrate core structure. (1994 - van Halbeek H, Strang A, Lhermitte M, Rahmoune H, Lamblin G, Roussel P) / Status : Reviewed
Oligosaccharide structures of mucins secreted by the human colonic cancer cell line CL.16E. (1992 - Capon C, Laboisse C, Wieruszeski J, Maoret J, Augeron C, Fournet B) / Status : Reviewed
1H and 13C-NMR assignments for sialylated oligosaccharide-alditols related to mucins. Study of thirteen components from hen ovomucin and swallow nest mucin. (1992 - Strecker G, Wieruszeski J, Cuvillier O, Michalski J, Montreuil J) / Status : Reviewed
Structure determination of the major N- and O-linked carbohydrate chains of the beta subunit from equine chorionic gonadotropin. (1990 - Damm J, Hard K, Kamerling J, van Dedem G, Vliegenthart J) / Status : Reviewed
Comparative study of the mucin-type sugar chains of human chorionic gonadotropin present in the urine of patients with trophoblastic diseases and healthy pregnant women. (1988 - Amano J, Nishimura R, Mochizuki M, Kobata A) / Status : Reviewed
Structure of sialyl-oligosaccharides isolated from bronchial mucus glycoproteins of patients (blood group O) suffering from cystic fibrosis. (1987 - Breg J, Van Halbeek H, Vliegenthart J, Lamblin G, Houvenaghel M, Roussel P) / Status : Reviewed
Structures of O-linked oligosaccharides isolated from normal granulocytes, chronic myelogenous leukemia cells, and acute myelogenous leukemia cells. (1986 - Fukuda M, Carlsson S, Klock J, Dell A) / Status : Reviewed
Structural variations of O-linked oligosaccharides present in leukosialin isolated from erythroid, myeloid, and T-lymphoid cell lines. (1986 - Carlsson S, Sasaki H, Fukuda M) / Status : Reviewed
The structure of the O-glycosidic oligosaccharide chains of the major Zajdela hepatoma ascites-cell-membrane glycoprotein. (1986 - Nato F, Goulut C, Bourrillon R, Van Halbeek H, Vliegenthart J) / Status : Reviewed
The carbohydrate moiety of human platelet glycocalicin. (1983 - Tsuji T, Tsunehisa S, Watanabe Y, Yamamoto K, Tohyama H, Osawa T) / Status : Reviewed
Structure of O-glycosidically linked sugar units from plasma membranes of an ascites hepatoma, AH 66. (1982 - Funakoshi I, Yamashina I) / Status : Reviewed

Reported glycosite

Angiotensin-converting enzyme 2 / Homo sapiens
- Undefined site
Choriogonadotropin - alpha and beta chains / Homo sapiens
- Undefined site
Glycocalicin / Homo sapiens
- Undefined site
Leukosialin (cd43) / Homo sapiens
- Undefined site
Muc1 fusion protein / Homo sapiens
- Undefined site
Uncharacterized protein / Homo sapiens
- Undefined site
Uncharacterized protein / Homo sapiens
- Undefined site
Unspecified mucin / Homo sapiens
- Undefined site
Zona pellucida sperm-binding protein 3 / Homo sapiens
- Undefined site
Choriogonadotropin beta chain / Equus caballus
- Undefined site
Brain non dialyzable glycopeptide / Oryctolagus cuniculus
- Undefined site
Major membrane glycoprotein - MII2 / Rattus norvegicus
- Undefined site
Uncharacterized protein from Liver / Rattus norvegicus
- Undefined site
Mucin / Collocalia sp
- Undefined site

Mass spectrometry observed peptide

- O-Linked / Core 2 (avg mass : 1039.948)

Cross-references

GlyTouCan : G11457RF

UniCarb-DB :

Composition

Hex:2 HexNAc:2 NeuAc:1

IUPAC

NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc

GlycoCT

RES
1b:a-dgal-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:b-dglc-HEX-1:5
5s:n-acetyl
6b:b-dgal-HEX-1:5
7b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
8s:n-acetyl
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:1o(6+1)4d
4:4d(2+1)5n
5:4o(4+1)6d
6:6o(3+2)7d
7:7d(5+1)8n