Structure

Taxonomy

• Homo sapiens (Human)
• Bos taurus (Bovine)
• Oryctolagus cuniculus (Rabbit)
• Rattus norvegicus (Norway rat)
• Rana temporaria (Common frog)
• Rana utricularia

Protein

• Immunoglobulin heavy constant alpha 1 / Homo sapiens    P01876
• Mucin / Bos taurus    
• Brain non dialyzable glycopeptide / Oryctolagus cuniculus    
• Uncharacterized protein from Brain / Rattus norvegicus    
• Mucin / Rana temporaria    
• Mucin / Rana utricularia    

Source

• Blood Plasma (UBERON_0001969)  
• Brain (UBERON_0000955)  
• Submandibular Gland (UBERON_0001736)  
• Egg Cell   Jelly Coat  

Reported structure

• O-Linked / Core 8 / Gal(a1-3)GalNAc

Composition

• Hex:1 HexNAc:1 (avg mass : 383.3527 )

Disease

• Control/Healthy
• Myeloma, Multiple (DOID:9538)

Reference

• Naturally Occurring Structural Isomers in Serum IgA1 O-Glycosylation (2012 - Kazuo Takahashi, Archer D. Smith, IV, Knud Poulsen, Mogens Kilian, Bruce A. Julian, Jiri Mestecky, Jan Novak, Matthew B. Renfrow) / Status : Reviewed
• High prevalence of 2-mono- and 2,6-di-substituted manol-terminating sequences among O-glycans released from brain glycopeptides by reductive alkaline hydrolysis. (1999 - Chai W, Yuen C, Kogelberg H, Carruthers R, Margolis R, Feizi T, Lawson A) / Status : Reviewed
• Neutral core oligosaccharides of bovine submaxillary mucin--use of lead tetraacetate in the cold for establishing branch positions. (1998 - Martensson S, Levery S, Fang T, Bendiak B) / Status : Reviewed
• Structural analysis of the oligosaccharide-alditols released by reductive beta-elimination from oviducal mucins of Rana temporaria. (1997 - Maes E, Florea D, Delplace F, Lemoine J, Plancke Y, Strecker G) / Status : Reviewed
• Structural analysis of the oligosaccharide-alditols released by reductive beta-elimination from the jelly coat of Rana utricularia eggs. (1997 - Morelle W, Strecker G) / Status : Reviewed
• Structure of the O-glycosidically linked carbohydrate units of rat brain glycoproteins. (1975 - Finne J) / Status : Reviewed

Reported glycosite

• Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •        Thr-106
  •        Thr-109
  •        Ser-111
  •        Ser-113
  •        Thr-114
  •        Thr-117
• Mucin / Bos taurus
  •        Undefined site
• Brain non dialyzable glycopeptide / Oryctolagus cuniculus
  •        Undefined site
• Uncharacterized protein from Brain / Rattus norvegicus
  •        Undefined site
• Mucin / Rana temporaria
  •        Undefined site
• Mucin / Rana utricularia
  •        Undefined site

Mass spectrometry observed peptide

• HYTNPSQDVTVPCPVPSTPPTPSP (24aa)
  •    P01876    Thr-106     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Ser-111     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Ser-113     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Thr-109     Immunoglobulin heavy constant alpha 1 / Homo sapiens
• STPPTPSPSCCHPR (14aa)
  •    P01876    Thr-117     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Thr-114     Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •    P01876    Ser-113     Immunoglobulin heavy constant alpha 1 / Homo sapiens

Gal(a1-3)GalNAc

RES
1b:a-dgal-HEX-1:5
2s:n-acetyl
3b:a-dgal-HEX-1:5
LIN
1:1d(2+1)2n
2:1o(3+1)3d