GlyConnect

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taxonomy (12) protein (25) source (18) structure (1) composition (1) disease (9) reference (33) site (25) peptide (0)

Taxonomy

Protein

Source

Reported structure

O-Linked / Core 1 / Fuc(a1-2)Gal(b1-3)GalNAc

Composition

Hex:1 HexNAc:1 dHex:1 (avg mass : 529.4957 )

Disease

Reference

Colorectal cancer cell lines show striking diversity of their O-glycome reflecting the cellular differentiation phenotype (2021 - Katarina Madunić, Tao Zhang, Oleg A Mayboroda, Stephanie Holst, Kathrin Stavenhagen, Chunsheng Jin, Niclas G Karlsson, Guinevere S M Lageveen-Kammeijer, Manfred Wuhrer) / Status : Reviewed
Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor (2020 - Peng Zhao, Jeremy L. Praissman, Oliver C. Grant, Yongfei Cai, Tianshu Xiao, Katelyn E. Rosenbalm, Kazuhiro Aoki, Benjamin P. Kellman, Robert Bridger, Dan H. Barouch, Melinda A. Brindley, Nathan E. Lewis, Michael Tiemeyer, Bing Chen, Robert J. Woods, Lance Wells) / Status : Reviewed
Comparative study of carbohydrate chains released from the oviducal mucins of the two very closely related amphibian species Bombina bombina and Bombina variegata. (2003 - Coppin A, Florea D, Maes E, CogÃ¡lniceanu D, Strecker G) / Status : Reviewed
Intestinal mucins from cystic fibrosis mice show increased fucosylation due to an induced Fucalpha1-2 glycosyltransferase. (2002 - Thomsson KA, Hinojosa-Kurtzberg M, Axelsson KA, Domino SE, Lowe JB, Gendler SJ, Hansson GC) / Status : Reviewed
In vivo glycosylation of mucin tandem repeats (2001 - Silverman, Parry, Sutton-Smith, Burdick, McDermott, Reid, Batra, Morris, Hollingsworth, Dell, Harris) / Status : Reviewed
Structural analysis of 13 neutral oligosaccharide-alditols released by reductive beta-elimination from oviducal mucins of Rana temporaria (1999 - Coppin, Maes, Morelle, Strecker) / Status : Reviewed
Acquisition of species-specific O-linked carbohydrate chains from oviducal mucins in Rana arvalis. A case study (1999 - Coppin, Maes, Flahaut, Coddeville, Strecker) / Status : Reviewed
Neutral core oligosaccharides of bovine submaxillary mucin--use of lead tetraacetate in the cold for establishing branch positions. (1998 - Martensson S, Levery S, Fang T, Bendiak B) / Status : Reviewed
Structural analysis of oligosaccharide-alditols released by reductive beta-elimination from the jelly coats of the anuran Bufo arenarum. (1998 - Morelle W, Cabada M, Strecker G) / Status : Reviewed
Structural analysis of the oligosaccharide-alditols released by reductive beta-elimination from the jelly coat of Rana utricularia eggs. (1997 - Morelle W, Strecker G) / Status : Reviewed
Isolation, structural determination, and calcium-binding properties of the major glycoprotein present in Bufo japonicus japonicus egg jelly. (1994 - Shimoda Y, Kitajima K, Inoue S, Inoue Y) / Status : Reviewed
An improved approach to the analysis of the structure of small oligosaccharides of glycoproteins: application to the O-linked oligosaccharides from human glycophorin A. (1993 - Krotkiewski H, Lisowska E, Nilsson G, Grnberg G, Nilsson B) / Status : Reviewed
The broad diversity of neutral and sialylated oligosaccharides derived from human salivary mucins. (1992 - Klein A, Carnoy C, Wieruszeski J, Strecker G, Strang A, van Halbeek H, Roussel P, Lamblin G) / Status : Reviewed
Structural characterization of neutral oligosaccharides with blood-group A and H activity isolated from bovine submaxillary mucin. (1991 - Savage A, D'Arcy S, Donoghue C) / Status : Reviewed
Primary structure of neutral oligosaccharides derived from respiratory-mucus glycoproteins of a patient suffering from bronchiectasis, determined by combination of 500-MHz 1H-NMR spectroscopy and quantitative sugar analysis. 1. Structure of 16 oligosaccharides having the Gal beta(1---3)GalNAc-ol cor (1988 - Klein A, Lamblin G, Lhermitte M, Roussel P, Breg J, Van Halbeek H, Vliegenthart J) / Status : Reviewed
Characterization of the oligosaccharide alditols from ovarian cyst mucin glycoproteins of blood group A using high pressure liquid chromatography (HPLC) and high field 1H NMR spectroscopy. (1986 - Dua VK, Rao BN, Wu SS, Dube VE, Bush CA) / Status : Reviewed
Structure of neutral oligosaccharides derived from mucus glycoproteins of human seminal plasma. (1986 - Hanisch F-G, Egge H, Peter-Katalinic J, Uhlenbruck G) / Status : Reviewed
Oligosaccharide structures of the low-molecular-weight salivary mucin from a normal individual and one with cystic fibrosis. (1985 - Reddy M, Levine M, Prakobphol A) / Status : Reviewed
Purification and structures of oligosaccharide chains in swine trachea and Cowper's gland mucin glycoproteins. (1984 - Rana SS, Chandrasekaran EV, Kennedy J, Mendicino J) / Status : Reviewed
The combination of normal-phase and reverse-phase high-pressure liquid chromatography with NMR for the isolation and characterization of oligosaccharide alditols from ovarian cyst mucins. (1984 - Dua V, Dube V, Bush C) / Status : Reviewed
Isolation and characterisation of neutral oligosaccharides from human bronchial glycoproteins. (1982 - Lamblin G, Lhermitte M, Boersma A, Roussel P, Van Halbeek H, Dorland L, Vliegenthart J) / Status : Reviewed
Primary-structure determination of fourteen neutral oligosaccharides derived from bronchial-mucus glycoproteins of patients suffering from cystic fibrosis, employing 500-MHz 1H-NMR spectroscopy. (1982 - van Halbeek H, Dorland L, Vliegenthart J, Hull W, Lamblin G, Lhermitte M, Boersma A, Roussel P) / Status : Reviewed
Structure determination of oligosaccharides isolated from A+, H+ and A-H- hog-submaxillary-gland mucin glycoproteins, by 360-MHz 1H-NMR spectroscopy, permethylation analysis and mass spectrometry. (1981 - van Halbeek H, Dorland L, Haverkamp J, Veldink G, Vliegenthart J, Fournet B, Ricart G, Montreuil J, Gathmann W, Aminoff D) / Status : Reviewed
Oligosaccharides of human bronchial glycoproteins. Neutral di- and trisaccharides isolated from a patient suffering from chronic bronchitis. (1980 - Lamblin G, Lhermitte M, Boersma A, Roussel P, Reinhold V) / Status : Reviewed
Glycoproteins and blood group activity. Oligosaccharides of A+ hog submaxillary glycoproteins. (1979 - Aminoff D, Baig MM, Gathmann WD) / Status : Reviewed
Glycoproteins and blood group activity. Isolation and characterization of oligosaccharides of H+ hog submaxillary glycoprotein, and their comparison to those found in A+ and A-H- glycoproteins. (1979 - Aminoff D, Gathmann WD, Baig MM) / Status : Reviewed
Structure of some oligosaccharides derived from rat-intestinal glycoproteins. (1978 - Carlsson H, Sundblad G, Hammarstrm S, Lnngren J) / Status : Reviewed
The sugar chain structures of ABO blood group active glycoproteins obtained from human erythrocyte membrane. (1978 - Takasaki S, Yamashita K, Kobata A) / Status : Reviewed
Immunochemical studies on blood groups. Structures and immunochemical properties of oligosaccharides from two fractions of blood group substance from human ovarian cyst fluid differing in B, I, and i activities and reactivity toward concanavalin A. (1976 - Maisonrouge-McAuliffe F, Kabat E) / Status : Reviewed
Immunochemical studies on blood groups. Immunochemical properties of B-active and non-B-active blood group substances from horse gastric mucosae and the relative size distributions of oligosaccharides liberated by base-borohydride. (1976 - Newman W, Kabat E) / Status : Reviewed
Intestinal glycoproteins of germfree rats. IV. Oligosaccharides obtained by chemical degradation of a water-soluble glycoprotein fraction. (1975 - Wold J, Smestad B, Midtvedt T) / Status : Reviewed
Structures of oligosaccharides produced by base--borohydride degradation of human ovarian cyst blood group H, Le-b and Le-a active glycoproteins. (1973 - Rovis L, Anderson B, Kabat E, Gruenzo F, Liao J) / Status : Reviewed
Structures and immunochemical properties of oligosaccharides isolated from pig submaxillary mucins. (1968 - Carlson D) / Status : Reviewed

Reported glycosite

Angiotensin-converting enzyme 2 / Homo sapiens
- Undefined site
Glycophorin-A / Homo sapiens
- Undefined site
Glycoprotein ln / Homo sapiens
- Undefined site
Glycoprotein rg / Homo sapiens
- Undefined site
Mucin-7 / Homo sapiens
- Undefined site
Recombinant Mucin-1 Muc1f (delta tr) / Homo sapiens
- Undefined site
Recombinant Mucin-1 Muc1f/2tr / Homo sapiens
- Undefined site
Recombinant Mucin-1 Muc1f/4tr / Homo sapiens
- Undefined site
Recombinant Mucin-1 Muc1f/5actr / Homo sapiens
- Undefined site
Recombinant Mucin-1 Muc1f/5btr / Homo sapiens
- Undefined site
Uncharacterized protein / Homo sapiens
- Undefined site
Uncharacterized protein from Ovary / Homo sapiens
- Undefined site
Uncharacterized protein from Seminal Fluid / Homo sapiens
- Undefined site
Unspecified mucin / Homo sapiens
- Undefined site
Mucin / Bos taurus
- Undefined site
Mucin / Equus caballus
- Undefined site
Muc2 / Mus musculus
- Undefined site
Mucin / Rattus norvegicus
- Undefined site
Mucin / Sus scrofa
- Undefined site
Mucin / Bombina variegata
- Undefined site
Mucin / Bufo arenarum
- Undefined site
Uncharacterized protein / Bufo japonicus
- Undefined site
Mucin / Rana arvalis
- Undefined site
Mucin / Rana temporaria
- Undefined site
Mucin / Rana utricularia
- Undefined site

Mass spectrometry observed peptide

- O-Linked / Core 1 (avg mass : 529.4957)

3D structure from GLYCAM

Cross-references

GlyTouCan : G94435QH

GlyGen : G94435QH

ChEBI : 62152

UniCarb-DB :

Composition

Hex:1 HexNAc:1 dHex:1

IUPAC

Fuc(a1-2)Gal(b1-3)GalNAc

GlycoCT

RES
1b:a-dgal-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:a-lgal-HEX-1:5|6:d
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:3o(2+1)4d

GWS

freeEnd--?a1D-GalNAc,p--3b1D-Gal,p--2a1L-Fuc,p$MONO,Und,0,0,freeEnd

Glycam

LFucpa1-2DGalpb1-3DGalpNAca1-OH

SMILES

C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O[C@@H]2[C@H]([C@H]([C@H](O[C@H]2O[C@@H]3[C@H]([C@H](O[C@@H]([C@@H]3O)CO)O)NC(=O)C)CO)O)O)O)O)O

InCHI key

MGSDFCKWGHNUSM-AKRVIRTESA-N

InCHI

InChI=1S/C20H35NO15/c1-5-10(25)13(28)15(30)19(32-5)36-17-14(29)11(26)7(3-22)34-20(17)35-16-9(21-6(2)24)18(31)33-8(4-23)12(16)27/h5,7-20,22-23,25-31H,3-4H2,1-2H3,(H,21,24)/t5-,7+,8+,9+,10+,11-,12-,13+,14-,15-,16+,17+,18-,19-,20-/m0/s1