Primary structure determination of five sialylated oliogsaccharides derived from bronchial mucus glycoproteins of patients suffering from cystic fibrosis. The occurrence of the NeuAc alpha(2---3)Gal beta(1---4)[Fuc alpha(1---3)] GlcNAc beta(1---.) structural element revealed by 500-MHz 1H NMR spectr (1984)
Lamblin G, Boersma A, Klein A, Roussel P, van Halbeek H, Vliegenthart J
J Biol Chem, 1984 vol.259:9051-9058
SNFG,
Text,
Oxford
taxonomy (1)
protein (1)
source (1)
structure (5)
composition (5)
disease (1)
reference (1)
site (1)
peptide (0)
- Homo sapiens (Human)
Taxonomy
- Unspecified mucin / Homo sapiens
Protein
- Pulmonary Mucosa
Source
- O-Linked / Core 1 / NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-3)GalNAc
- O-Linked / Core 3 / NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)GalNAc
- O-Linked / Core 4 / NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)[GlcNAc(b1-3)]GalNAc
- O-Linked / Core 4 / NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-6)[GlcNAc(b1-3)]GalNAc
- O-Linked / Core 4 / NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-6)[Gal(b1-4)GlcNAc(b1-3)]GalNAc
Reported structure
- Hex:1 HexNAc:2 dHex:1 NeuAc:1 (avg mass : 1023.9486 )
- Hex:1 HexNAc:3 NeuAc:1 (avg mass : 1081.0006 )
- Hex:1 HexNAc:3 dHex:1 NeuAc:1 (avg mass : 1227.1436 )
- Hex:2 HexNAc:2 dHex:1 NeuAc:1 (avg mass : 1186.091 )
- Hex:2 HexNAc:3 dHex:1 NeuAc:1 (avg mass : 1389.286 )
Composition
- Cystic Fibrosis (DOID:1485)
Disease
-
Unspecified mucin / Homo sapiens
- Undefined site
Reported glycosite
Mass spectrometry observed peptide
-
- O-Linked / Core 1
(avg mass : 1186.091)
- Pulmonary Mucosa
- Cystic Fibrosis (DOID:1485)
-
Unspecified mucin / Homo sapiens
- Undefined site
-
- O-Linked / Core 3
(avg mass : 1023.9486)
- Pulmonary Mucosa
- Cystic Fibrosis (DOID:1485)
-
Unspecified mucin / Homo sapiens
- Undefined site
-
- O-Linked / Core 4
(avg mass : 1081.0006)
- Pulmonary Mucosa
- Cystic Fibrosis (DOID:1485)
-
Unspecified mucin / Homo sapiens
- Undefined site
-
- O-Linked / Core 4
(avg mass : 1227.1436)
- Pulmonary Mucosa
- Cystic Fibrosis (DOID:1485)
-
Unspecified mucin / Homo sapiens
- Undefined site
-
- O-Linked / Core 4
(avg mass : 1389.286)
- Pulmonary Mucosa
- Cystic Fibrosis (DOID:1485)
-
Unspecified mucin / Homo sapiens
- Undefined site
Source
Disease
Reported glycosite
- O-Linked / Core 4
(avg mass : 1389.286)
Source
Disease
Reported glycosite
- O-Linked / Core 4
(avg mass : 1227.1436)
Source
Disease
Reported glycosite
- O-Linked / Core 4
(avg mass : 1081.0006)
Source
Disease
Reported glycosite
- O-Linked / Core 3
(avg mass : 1023.9486)
Source
Disease
Reported glycosite
- O-Linked / Core 1
(avg mass : 1186.091)