Coagulation factor VII

Taxonomy

• Homo sapiens (Human)

Protein

• Coagulation factor VII / Homo sapiens    P08709

Source

• Blood Plasma (UBERON_0001969)  
• Kidney (UBERON_0002113)   BHK-21 (CVCL_1914)  

Reported structure

• O-Linked / No-core / Xyl(?1-?)Glc+"+ Xyl"
• O-Linked / O-Fuc / Fuc
• O-Linked / O-Glc / Glc
• O-Linked / O-Glc / Xyl(?1-?)Glc

Composition

• dHex:1 (avg mass : 164.1583 )
• Hex:1 (avg mass : 180.1577 )
• Hex:1 Pent:1 (avg mass : 312.2738 )
• Hex:1 Pent:2 (avg mass : 444.3899 )

Disease

Reference

• Human plasma and recombinant factor VII. Characterization of O-glycosylations at serine residues 52 and 60 and effects of site-directed mutagenesis of serine 52 to alanine. (1991 - Bjoern S, Foster D, Thim L, Wiberg F, Christensen M, Komiyama Y, Pedersen A, Kisiel W) / Status : Reviewed
• Identification of a disaccharide (Xyl-Glc) and a trisaccharide (Xyl2-Glc) O-glycosidically linked to a serine residue in the first epidermal growth factor-like domain of human factors VII and IX and protein Z and bovine protein Z. (1989 - Nishimura H, Kawabata S, Kisiel W, Hase S, Ikenaka T, Takao T, Shimonishi Y, Iwanaga S) / Status : Reviewed

Reported glycosite

• Coagulation factor VII / Homo sapiens
  •        Undefined site
  •        Ser-112
  •        Ser-120

Mass spectrometry observed peptide