Coagulation factor IX

Taxonomy

• Bos taurus (Bovine)

Protein

• Coagulation factor IX / Bos taurus    P00741

Source

• Blood Plasma (UBERON_0001969)  

Reported structure

• O-Linked / No-core / Xyl(a1-3)Xyl(a1-3)Glc
• N-Linked / Complex / NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-3)[NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GlcNAc(b1-2)Man(a1-3)[NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GlcNAc(b1-2)Man(a1-3)[NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)]Man(a1-6)[NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GlcNAc(b1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GlcNAc(b1-6)[NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)]Man(a1-6)[NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GlcNAc(b1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

• Hex:1 Pent:2 (avg mass : 444.3899 )
• Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )
• Hex:5 HexNAc:4 NeuAc:3 (avg mass : 2515.281 )
• Hex:5 HexNAc:4 NeuAc:4 (avg mass : 2806.5389 )
• Hex:6 HexNAc:5 NeuAc:4 (avg mass : 3171.8763 )
• Hex:6 HexNAc:5 NeuAc:5 (avg mass : 3463.1342 )

Disease

Reference

• The structure of (xylose)2glucose-O-serine 53 found in the first epidermal growth factor-like domain of bovine blood clotting factor IX. (1990 - Hase S, Nishimura H, Kawabata S, Iwanaga S, Ikenaka T) / Status : Reviewed
• The structures of the carbohydrate moieties of bovine blood coagulation factor IX (Christmas factor). (1983 - Mizuochi T, Taniguchi T, Fujikawa K, Titani K, Kobata A) / Status : Reviewed

Reported glycosite

• Coagulation factor IX / Bos taurus
  •        Undefined site
  •        Ser-53

Mass spectrometry observed peptide