Protein-lysine 6-oxidase

Taxonomy

• Homo sapiens (Human)

Protein

• Protein-lysine 6-oxidase / Homo sapiens    P28300

Source

• Blood Serum (UBERON_0001977)  
• Mammary Gland (UBERON_0001911)  
• Umbilical Vein (UBERON_0002066)   Endothelial Cell of Umbilical Vein (CL_0002618)  
• Urine (UBERON_0001088)  

Reported structure

Composition

• Hex:3 HexNAc:6 dHex:1 NeuAc:2 (avg mass : 2452.2713 )
• Hex:4 HexNAc:2 (avg mass : 1072.9749 )
• Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )
• Hex:5 HexNAc:4 dHex:1 (avg mass : 1787.6503 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:1 NeuGc:1 (avg mass : 2386.1655 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:2 (avg mass : 2370.1661 )
• Hex:6 HexNAc:4 NeuAc:1 (avg mass : 2094.9076 )
• Hex:6 HexNAc:4 dHex:2 (avg mass : 2095.9357 )
• Hex:6 HexNAc:6 NeuAc:2 (avg mass : 2792.5555 )
• Hex:6 HexNAc:6 NeuAc:3 (avg mass : 3083.8134 )
• Hex:6 HexNAc:6 dHex:1 NeuAc:3 (avg mass : 3229.9564 )
• Hex:7 HexNAc:6 dHex:1 NeuAc:2 (avg mass : 3100.8409 )

Disease

• Cancer, breast (DOID:1612)
• Prostate cancer (DOID:10283)

Reference

• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Large-scale intact glycopeptide identification by Mascot database search (2018 - Ravi Chand Bollineni, Christian Jeffrey Koehler, Randi Elin Gislefoss, Jan Haug Anonsen, Bernd Thiede) / Status : Unreviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Glycoproteomic analysis of the secretome of human endothelial cells (2013 - Yin X, Bern M, Xing Q, Ho J, Viner R, Mayr M.) / Status : Reviewed

Reported glycosite

• Protein-lysine 6-oxidase / Homo sapiens
  •        Asn-81
  •        Asn-97
  •        Asn-144
  •        Asn-381

Mass spectrometry observed peptide

• RDPGAAVPGAANASAQQPR (19aa)
  •    P28300    Asn-81     Protein-lysine 6-oxidase / Homo sapiens
• DPGAAVPGAANASAQQPR (18aa)
  •    P28300    Asn-81     Protein-lysine 6-oxidase / Homo sapiens
• AENQTAPGEVPALSNLRPPSR (21aa)
  •    P28300    Asn-144     Protein-lysine 6-oxidase / Homo sapiens
• VSVNPSYLVPESDYTNNVVR (20aa)
  •    P28300    Asn-381     Protein-lysine 6-oxidase / Homo sapiens