GlyConnect

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Site	Core / Type	Cartoon	Composition	Biological associations
Thr-37	O-Linked / Undefined core		Hex:2 HexNAc:2 NeuAc:2	taxonomy (1) protein (1) source (1) structure (0) composition (1) disease (1) reference (1) site (1) peptide (2) Taxonomy Homo sapiens (Human) Protein Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Source Urine (UBERON_0001088) Reported structure Composition Hex:2 HexNAc:2 NeuAc:2 (avg mass : 1331.2059 ) Disease Prostate cancer (DOID:10283) Reference Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed Reported glycosite Proheparin-binding EGF-like growth factor / Homo sapiens Thr-37 Mass spectrometry observed peptide GLAAGTSNPDPPTVSTDQLLPLGGGRDR (28aa) Q99075 Thr-37 Proheparin-binding EGF-like growth factor / Homo sapiens GLAAGTSNPDPPTVSTDQLLPLGGGR (26aa) Q99075 Ser-46 Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Thr-47 Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Thr-37 Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Thr-44 Proheparin-binding EGF-like growth factor / Homo sapiens
Thr-37	O-Linked / Undefined core		Hex:1 HexNAc:1 NeuAc:3	taxonomy (1) protein (1) source (1) structure (0) composition (1) disease (1) reference (1) site (1) peptide (1) Taxonomy Homo sapiens (Human) Protein Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Source Urine (UBERON_0001088) Reported structure Composition Hex:1 HexNAc:1 NeuAc:3 (avg mass : 1257.1264 ) Disease Prostate cancer (DOID:10283) Reference Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed Reported glycosite Proheparin-binding EGF-like growth factor / Homo sapiens Thr-37 Mass spectrometry observed peptide GLAAGTSNPDPPTVSTDQLLPLGGGRDRK (29aa) Q99075 Thr-37 Proheparin-binding EGF-like growth factor / Homo sapiens
Thr-44	O-Linked / Undefined core		Hex:1 HexNAc:1	taxonomy (1) protein (1) source (1) structure (0) composition (1) disease (0) reference (1) site (1) peptide (0) Taxonomy Homo sapiens (Human) Protein Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Source Urine (UBERON_0001088) Reported structure Composition Hex:1 HexNAc:1 (avg mass : 383.3527 ) Disease Reference Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD (2012 - Halim A, Nilsson J, Rüetschi U, Hesse C, Larson G) / Status : Reviewed Reported glycosite Proheparin-binding EGF-like growth factor / Homo sapiens Thr-44 Mass spectrometry observed peptide
Thr-44	O-Linked / Undefined core		Hex:4 HexNAc:6	taxonomy (1) protein (1) source (1) structure (0) composition (1) disease (1) reference (1) site (1) peptide (1) Taxonomy Homo sapiens (Human) Protein Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Source Urine (UBERON_0001088) Reported structure Composition Hex:4 HexNAc:6 (avg mass : 1885.7549 ) Disease Prostate cancer (DOID:10283) Reference Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed Reported glycosite Proheparin-binding EGF-like growth factor / Homo sapiens Thr-44 Mass spectrometry observed peptide GLAAGTSNPDPPTVSTDQLLPLGGGR (26aa) Q99075 Ser-46 Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Thr-47 Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Thr-37 Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Thr-44 Proheparin-binding EGF-like growth factor / Homo sapiens
Thr-44	O-Linked / Undefined core		Hex:3 HexNAc:3 NeuAc:2	taxonomy (1) protein (1) source (1) structure (0) composition (1) disease (1) reference (1) site (2) peptide (1) Taxonomy Homo sapiens (Human) Protein Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Source Urine (UBERON_0001088) Reported structure Composition Hex:3 HexNAc:3 NeuAc:2 (avg mass : 1696.5433 ) Disease Prostate cancer (DOID:10283) Reference Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed Reported glycosite Proheparin-binding EGF-like growth factor / Homo sapiens Thr-44 Thr-47 Mass spectrometry observed peptide RGLAAGTSNPDPPTVSTDQLLPLGGGR (27aa) Q99075 Thr-47 Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Thr-44 Proheparin-binding EGF-like growth factor / Homo sapiens
Ser-46	O-Linked / Undefined core		Hex:3 HexNAc:6 dHex:1	taxonomy (1) protein (1) source (1) structure (0) composition (1) disease (1) reference (1) site (1) peptide (1) Taxonomy Homo sapiens (Human) Protein Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Source Urine (UBERON_0001088) Reported structure Composition Hex:3 HexNAc:6 dHex:1 (avg mass : 1869.7555 ) Disease Prostate cancer (DOID:10283) Reference Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed Reported glycosite Proheparin-binding EGF-like growth factor / Homo sapiens Ser-46 Mass spectrometry observed peptide GLAAGTSNPDPPTVSTDQLLPLGGGR (26aa) Q99075 Ser-46 Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Thr-47 Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Thr-37 Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Thr-44 Proheparin-binding EGF-like growth factor / Homo sapiens
Thr-47	O-Linked / Undefined core		Hex:1 HexNAc:1 NeuAc:2	taxonomy (1) protein (1) source (1) structure (0) composition (1) disease (1) reference (1) site (1) peptide (1) Taxonomy Homo sapiens (Human) Protein Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Source Urine (UBERON_0001088) Reported structure Composition Hex:1 HexNAc:1 NeuAc:2 (avg mass : 965.8685 ) Disease Prostate cancer (DOID:10283) Reference Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed Reported glycosite Proheparin-binding EGF-like growth factor / Homo sapiens Thr-47 Mass spectrometry observed peptide GLAAGTSNPDPPTVSTDQLLPLGGGR (26aa) Q99075 Ser-46 Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Thr-47 Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Thr-37 Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Thr-44 Proheparin-binding EGF-like growth factor / Homo sapiens
Thr-47	O-Linked / Undefined core		Hex:3 HexNAc:3 NeuAc:2	taxonomy (1) protein (1) source (1) structure (0) composition (1) disease (1) reference (1) site (2) peptide (1) Taxonomy Homo sapiens (Human) Protein Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Source Urine (UBERON_0001088) Reported structure Composition Hex:3 HexNAc:3 NeuAc:2 (avg mass : 1696.5433 ) Disease Prostate cancer (DOID:10283) Reference Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed Reported glycosite Proheparin-binding EGF-like growth factor / Homo sapiens Thr-44 Thr-47 Mass spectrometry observed peptide RGLAAGTSNPDPPTVSTDQLLPLGGGR (27aa) Q99075 Thr-47 Proheparin-binding EGF-like growth factor / Homo sapiens Q99075 Thr-44 Proheparin-binding EGF-like growth factor / Homo sapiens

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