Proheparin-binding EGF-like growth factor

Taxonomy

• Homo sapiens (Human)

Protein

• Proheparin-binding EGF-like growth factor / Homo sapiens    Q99075

Source

• Urine (UBERON_0001088)  

Reported structure

Composition

• Hex:1 HexNAc:1 (avg mass : 383.3527 )
• Hex:1 HexNAc:1 NeuAc:2 (avg mass : 965.8685 )
• Hex:1 HexNAc:1 NeuAc:3 (avg mass : 1257.1264 )
• Hex:2 HexNAc:2 NeuAc:2 (avg mass : 1331.2059 )
• Hex:3 HexNAc:3 NeuAc:2 (avg mass : 1696.5433 )
• Hex:3 HexNAc:6 dHex:1 (avg mass : 1869.7555 )
• Hex:4 HexNAc:6 (avg mass : 1885.7549 )

Disease

• Prostate cancer (DOID:10283)

Reference

• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD (2012 - Halim A, Nilsson J, Rüetschi U, Hesse C, Larson G) / Status : Reviewed

Reported glycosite

• Proheparin-binding EGF-like growth factor / Homo sapiens
  •        Thr-37
  •        Thr-44
  •        Ser-46
  •        Thr-47

Mass spectrometry observed peptide

• GLAAGTSNPDPPTVSTDQLLPLGGGR (26aa)
  •    Q99075    Ser-46
• GLAAGTSNPDPPTVSTDQLLPLGGGR (26aa)
  •    Q99075    Thr-37
• GLAAGTSNPDPPTVSTDQLLPLGGGR (26aa)
  •    Q99075    Thr-44
• GLAAGTSNPDPPTVSTDQLLPLGGGR (26aa)
  •    Q99075    Thr-47
• GLAAGTSNPDPPTVSTDQLLPLGGGRDRK (29aa)
  •    Q99075    Thr-37
• GLAAGTSNPDPPTVSTDQLLPLGGGRDR (28aa)
  •    Q99075    Thr-37
• RGLAAGTSNPDPPTVSTDQLLPLGGGR (27aa)
  •    Q99075    Thr-47
• RGLAAGTSNPDPPTVSTDQLLPLGGGR (27aa)
  •    Q99075    Thr-44