Complement component c6

Taxonomy

• Homo sapiens (Human)

Protein

• Complement component c6 / Homo sapiens    P13671

Source

• Blood Plasma (UBERON_0001969)  
• Blood Serum (UBERON_0001977)  
• Mammary Gland (UBERON_0001911)  

Reported structure

• N-Linked / Complex / NeuAc(?2-?)Gal(?1-?)GlcNAc(?1-?)Man(a1-3)[NeuAc(?2-?)Gal(?1-?)GlcNAc(?1-?)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

• Hex:4 HexNAc:6 dHex:2 (avg mass : 2178.0409 )
• Hex:5 HexNAc:4 NeuAc:1 (avg mass : 1932.7652 )
• Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )
• Hex:5 HexNAc:4 dHex:2 NeuAc:1 (avg mass : 2225.0512 )
• Hex:6 HexNAc:5 dHex:1 NeuAc:2 (avg mass : 2735.5035 )

Disease

• Cancer, breast (DOID:1612)
• Esophageal cancer (DOID:5041)
• Prostate cancer (DOID:10283)

Reference

• Large-scale intact glycopeptide identification by Mascot database search (2018 - Ravi Chand Bollineni, Christian Jeffrey Koehler, Randi Elin Gislefoss, Jan Haug Anonsen, Bernd Thiede) / Status : Unreviewed
• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Computational framework for identification of intact glycopeptides in complex samples (2014 - Mayampurath A, Yu CY, Song E, Balan J, Mechref Y, Tang H.) / Status : Reviewed

Reported glycosite

• Complement component c6 / Homo sapiens
  •        Asn-59
  •        Asn-324
  •        Asn-855
  •        Asn-910

Mass spectrometry observed peptide

• YYQENFCEQICSK (13aa)
  •    P13671    Asn-59
• VLNFTTK (7aa)
  •    P13671    Asn-324
• LSSNSTK (7aa)
  •    P13671    Asn-855
• TLNICEVGTIR (11aa)
  •    P13671    Asn-910