Complement factor b

Taxonomy

• Homo sapiens (Human)

Protein

• Complement factor b / Homo sapiens    P00751

Source

• Blood Serum (UBERON_0001977)  
• Mammary Gland (UBERON_0001911)  
• Milk (UBERON_0001913)  

Reported structure

• N-Linked / Complex / Structure 9464
• N-Linked / No-core / Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

• Hex:1 HexNAc:2 (avg mass : 586.5477 )
• Hex:3 HexNAc:8 dHex:1 (avg mass : 2276.1455 )
• Hex:4 HexNAc:3 NeuAc:1 (avg mass : 1567.4278 )
• Hex:4 HexNAc:5 NeuAc:2 (avg mass : 2265.0757 )
• Hex:5 HexNAc:2 (avg mass : 1235.1173 )
• Hex:5 HexNAc:3 NeuAc:1 (avg mass : 1729.5702 )
• Hex:5 HexNAc:4 NeuAc:1 (avg mass : 1932.7652 )
• Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )
• Hex:6 HexNAc:4 dHex:1 (avg mass : 1949.7927 )
• Hex:6 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2241.0506 )

Disease

• Cancer, breast (DOID:1612)

Reference

• Quantitative Longitudinal Inventory of the N-Glycoproteome of Human Milk from a Single Donor Reveals the Highly Variable Repertoire and Dynamic Site-Specific Changes (2020 - Jing Zhu, Yu-Hsien Lin, Kelly A Dingess, Marko Mank, Bernd Stahl, Albert J R Heck) / Status : Reviewed
• Site-Specific Profiling of Serum Glycoproteins Using N-Linked Glycan and Glycosite Analysis Revealing Atypical N-Glycosylation Sites on Albumin and α-1B-Glycoprotein (2018 - Shisheng Sun, Yingwei Hu, Li Jia, Shadi Toghi Eshghi, Yang Liu, Punit Shah, Hui Zhang) / Status : Unreviewed
• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Selective glycopeptide profiling by acetone enrichment and LC/MS (2014 - Takakura D, Harazono A, Hashii N, Kawasaki N) / Status : Reviewed

Reported glycosite

• Complement factor b / Homo sapiens
  •        Asn-122
  •        Asn-142
  •        Asn-285
  •        Asn-378

Mass spectrometry observed peptide

• SPYYNVSDEISFHCYDGYTIR (21aa)
  •    P00751    Asn-122     Complement factor b / Homo sapiens
• RSPYYNVSDEISFHCYDGYTLRGSANRT (28aa)
  •    P00751    Asn-142     Complement factor b / Homo sapiens
  •    P00751    Asn-122     Complement factor b / Homo sapiens
• IVLDPSGSMNIYLVLDGSDSIGASNFTGAKK (31aa)
  •    P00751    Asn-285     Complement factor b / Homo sapiens
• KIVLDPSGSMNIYLVLDGSDSIGASNFTGAK (31aa)
  •    P00751    Asn-285     Complement factor b / Homo sapiens
• IYLVLDGSDSIGASNFTGAK (20aa)
  •    P00751    Asn-285     Complement factor b / Homo sapiens
• VLDGSDSIGASNFTGAK (17aa)
  •    P00751    Asn-285     Complement factor b / Homo sapiens
• LVLDGSDSIGASNFTGAK (18aa)
  •    P00751    Asn-285     Complement factor b / Homo sapiens
• IVIDPSGSMNIYIVIDGSDSIGASNFTGAK (30aa)
  •    P00751    Asn-285     Complement factor b / Homo sapiens
• ALQAVYSMMSWPDDVPPEGWNR (22aa)
  •    P00751    Asn-378     Complement factor b / Homo sapiens