Haptoglobin

Taxonomy

• Homo sapiens (Human)

Protein

• Haptoglobin / Homo sapiens    P00738

Source

• Blood Plasma (UBERON_0001969)  
• Blood Serum (UBERON_0001977)  
• Mammary Gland (UBERON_0001911)  
• Milk (UBERON_0001913)  
• Urine (UBERON_0001088)  
• Cerebrospinal Fluid Secretion (GO_0033326)  

Reported structure

• N-Linked / Complex / Structure 2843
• N-Linked / Complex / Structure 1994
• N-Linked / Complex / Structure 2011
• N-Linked / Complex / Structure 9500
• N-Linked / Complex / Structure 3532
• N-Linked / Complex / Gal(?1-?)GlcNAc(?1-?)Man(a1-3)[Gal(?1-?)GlcNAc(?1-?)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / Structure 2708
• N-Linked / Complex / Structure 231
• N-Linked / Complex / Structure 9431
• N-Linked / Complex / Structure 9523
• N-Linked / Complex / Gal(?1-?)GlcNAc(?1-?)Man(a1-3)[Gal(?1-?)GlcNAc(?1-?)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / Structure 3041
• N-Linked / Complex / Structure 9474
• N-Linked / Complex / Structure 1344
• N-Linked / Complex / Structure 3507
• N-Linked / Complex / Structure 32
• N-Linked / Complex / Structure 9430
• N-Linked / Complex / Structure 644
• N-Linked / Complex / Structure 9457
• N-Linked / Complex / Structure 183
• N-Linked / Complex / Structure 9455
• N-Linked / Complex / Structure 1523
• N-Linked / Complex / Structure 9390
• N-Linked / Complex / Structure 9374
• N-Linked / Complex / Structure 3534
• N-Linked / Complex / Structure 9385
• N-Linked / Complex / NeuAc(?2-?)Gal(?1-?)GlcNAc(?1-?)Man(a1-3)[NeuAc(?2-?)Gal(?1-?)GlcNAc(?1-?)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / Structure 538
• N-Linked / Complex / Structure 9425
• N-Linked / Complex / Structure 9486
• N-Linked / Complex / Structure 9368
• N-Linked / Complex / Structure 9487
• N-Linked / Complex / Structure 9470
• N-Linked / Complex / Structure 3232
• N-Linked / Complex / Structure 9508
• N-Linked / Complex / Structure 1280
• N-Linked / Complex / Structure 1519
• N-Linked / Complex / Structure 9372
• N-Linked / Complex / Structure 720
• N-Linked / Complex / Structure 9498
• N-Linked / Complex / Structure 9499
• N-Linked / Complex / Structure 257
• N-Linked / Complex / Structure 9512
• N-Linked / Complex / Structure 3126
• N-Linked / Complex / Structure 1479
• N-Linked / Complex / Structure 2391
• N-Linked / Complex / Structure 9462
• N-Linked / Complex / Structure 9490
• N-Linked / Complex / Structure 3528
• N-Linked / Complex / Structure 9494
• N-Linked / Complex / Structure 3627
• N-Linked / Complex / Structure 2121
• N-Linked / Complex / Structure 2575
• N-Linked / Complex / Structure 9414
• N-Linked / Complex / Structure 9517
• N-Linked / Complex / Structure 9482
• N-Linked / Complex / Structure 1991
• N-Linked / Complex / Structure 3629
• N-Linked / Complex / Structure 9441
• N-Linked / Complex / Structure 9465
• N-Linked / Complex / Structure 791
• N-Linked / Complex / Structure 9480
• N-Linked / Complex / Structure 1437
• N-Linked / Complex / Structure 3185
• N-Linked / Complex / Structure 9421
• N-Linked / Complex / Structure 495
• N-Linked / Complex / Structure 9522
• N-Linked / Complex / Structure 452
• N-Linked / Complex / Structure 9388
• N-Linked / Complex / Structure 2404
• N-Linked / Complex / Structure 2448
• N-Linked / Hybrid / Structure 9371
• N-Linked / Hybrid / Structure 9493
• N-Linked / Hybrid / Structure 9506
• N-Linked / Hybrid / Structure 9440
• N-Linked / Hybrid / Structure 9428
• N-Linked / Pauci-Mannose / Man(a1-3)[Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Pauci-Mannose / Man(a1-3)[Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Undefined core / Fuc(??-?)[HexNAc(??-?)]Hex(??-?)[Fuc(??-?)]HexNAc(??-?)Hex(??-?)[HexNAc(??-?)Hex(??-?)]Hex(??-?)HexNAc(??-?)[Fuc(??-?)]HexNAc
• N-Linked / Undefined core / NeuAc(??-?)Hex(??-?)HexNAc(??-?)Hex(??-?)[NeuAc(??-?)Hex(??-?)HexNAc(??-?)Hex(??-?)]Hex(??-?)HexNAc(??-?)HexNAc
• N-Linked / Undefined core / HexNAc(??-?)HexNAc(??-?)[HexNAc(??-?)]Hex(??-?)[HexNAc(??-?)HexNAc(??-?)[HexNAc(??-?)HexNAc(??-?)]Hex(??-?)]Hex(??-?)HexNAc(??-?)HexNAc

Composition

• HexNAc:1 (avg mass : 221.2103 )
• Hex:3 HexNAc:2 (avg mass : 910.8325 )
• Hex:3 HexNAc:2 dHex:1 (avg mass : 1056.9755 )
• Hex:3 HexNAc:3 (avg mass : 1114.0275 )
• Hex:3 HexNAc:3 dHex:2 NeuAc:2 (avg mass : 1988.8293 )
• Hex:3 HexNAc:6 dHex:1 NeuAc:2 (avg mass : 2452.2713 )
• Hex:3 HexNAc:6 dHex:2 NeuAc:1 (avg mass : 2307.1564 )
• Hex:3 HexNAc:9 (avg mass : 2333.1975 )
• Hex:4 HexNAc:3 (avg mass : 1276.1699 )
• Hex:4 HexNAc:3 NeuAc:1 (avg mass : 1567.4278 )
• Hex:4 HexNAc:3 dHex:1 (avg mass : 1422.3129 )
• Hex:4 HexNAc:3 dHex:1 NeuAc:1 (avg mass : 1713.5708 )
• Hex:4 HexNAc:4 (avg mass : 1479.3649 )
• Hex:4 HexNAc:4 NeuAc:1 (avg mass : 1770.6228 )
• Hex:4 HexNAc:4 dHex:2 (avg mass : 1771.6509 )
• Hex:4 HexNAc:4 dHex:2 NeuAc:1 (avg mass : 2062.9088 )
• Hex:4 HexNAc:5 NeuAc:1 (avg mass : 1973.8178 )
• Hex:4 HexNAc:5 NeuAc:2 (avg mass : 2265.0757 )
• Hex:4 HexNAc:5 dHex:2 NeuAc:1 (avg mass : 2266.1038 )
• Hex:4 HexNAc:5 dHex:3 (avg mass : 2120.9889 )
• Hex:4 HexNAc:6 dHex:2 (avg mass : 2178.0409 )
• Hex:5 HexNAc:3 dHex:1 (avg mass : 1584.4553 )
• Hex:5 HexNAc:4 (avg mass : 1641.5073 )
• Hex:5 HexNAc:4 NeuAc:1 (avg mass : 1932.7652 )
• Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )
• Hex:5 HexNAc:4 dHex:1 (avg mass : 1787.6503 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:2 (avg mass : 2370.1661 )
• Hex:5 HexNAc:4 dHex:2 (avg mass : 1933.7933 )
• Hex:5 HexNAc:4 dHex:2 NeuAc:1 (avg mass : 2225.0512 )
• Hex:5 HexNAc:4 dHex:3 (avg mass : 2079.9363 )
• Hex:5 HexNAc:4 dHex:3 NeuAc:1 (avg mass : 2371.1942 )
• Hex:5 HexNAc:4 dHex:3 NeuAc:2 (avg mass : 2662.4521 )
• Hex:5 HexNAc:4 dHex:4 (avg mass : 2226.0793 )
• Hex:5 HexNAc:5 (avg mass : 1844.7023 )
• Hex:5 HexNAc:5 NeuAc:1 (avg mass : 2135.9602 )
• Hex:5 HexNAc:5 NeuAc:2 (avg mass : 2427.2181 )
• Hex:5 HexNAc:5 dHex:1 NeuAc:1 (avg mass : 2282.1032 )
• Hex:5 HexNAc:5 dHex:2 NeuAc:1 (avg mass : 2428.2462 )
• Hex:5 HexNAc:6 dHex:1 (avg mass : 2194.0403 )
• Hex:5 HexNAc:6 dHex:1 NeuAc:2 (avg mass : 2776.5561 )
• Hex:6 HexNAc:3 dHex:2 (avg mass : 1892.7407 )
• Hex:6 HexNAc:4 NeuAc:1 (avg mass : 2094.9076 )
• Hex:6 HexNAc:4 NeuAc:2 (avg mass : 2386.1655 )
• Hex:6 HexNAc:4 dHex:1 (avg mass : 1949.7927 )
• Hex:6 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2241.0506 )
• Hex:6 HexNAc:5 (avg mass : 2006.8447 )
• Hex:6 HexNAc:5 NeuAc:1 (avg mass : 2298.1026 )
• Hex:6 HexNAc:5 NeuAc:2 (avg mass : 2589.3605 )
• Hex:6 HexNAc:5 NeuAc:3 (avg mass : 2880.6184 )
• Hex:6 HexNAc:5 dHex:1 (avg mass : 2152.9877 )
• Hex:6 HexNAc:5 dHex:1 NeuAc:1 (avg mass : 2444.2456 )
• Hex:6 HexNAc:5 dHex:1 NeuAc:2 (avg mass : 2735.5035 )
• Hex:6 HexNAc:5 dHex:1 NeuAc:3 (avg mass : 3026.7614 )
• Hex:6 HexNAc:5 dHex:2 (avg mass : 2299.1307 )
• Hex:6 HexNAc:5 dHex:2 NeuAc:1 (avg mass : 2590.3886 )
• Hex:6 HexNAc:5 dHex:2 NeuAc:2 (avg mass : 2881.6465 )
• Hex:6 HexNAc:5 dHex:3 (avg mass : 2445.2737 )
• Hex:6 HexNAc:5 dHex:3 NeuAc:1 (avg mass : 2736.5316 )
• Hex:6 HexNAc:5 dHex:4 (avg mass : 2591.4167 )
• Hex:6 HexNAc:6 dHex:1 NeuAc:2 (avg mass : 2938.6985 )
• Hex:7 HexNAc:3 dHex:2 (avg mass : 2054.8831 )
• Hex:7 HexNAc:5 (avg mass : 2168.9871 )
• Hex:7 HexNAc:5 dHex:1 NeuAc:2 (avg mass : 2897.6459 )
• Hex:7 HexNAc:6 (avg mass : 2372.1821 )
• Hex:7 HexNAc:6 NeuAc:1 (avg mass : 2663.44 )
• Hex:7 HexNAc:6 NeuAc:2 (avg mass : 2954.6979 )
• Hex:7 HexNAc:6 NeuAc:3 (avg mass : 3245.9558 )
• Hex:7 HexNAc:6 NeuAc:4 (avg mass : 3537.2137 )
• Hex:7 HexNAc:6 dHex:1 (avg mass : 2518.3251 )
• Hex:7 HexNAc:6 dHex:1 NeuAc:1 (avg mass : 2809.583 )
• Hex:7 HexNAc:6 dHex:1 NeuAc:2 (avg mass : 3100.8409 )
• Hex:7 HexNAc:6 dHex:1 NeuAc:3 (avg mass : 3392.0988 )
• Hex:7 HexNAc:6 dHex:1 NeuAc:4 (avg mass : 3683.3567 )
• Hex:7 HexNAc:6 dHex:2 (avg mass : 2664.4681 )
• Hex:7 HexNAc:6 dHex:2 NeuAc:1 (avg mass : 2955.726 )
• Hex:7 HexNAc:6 dHex:2 NeuAc:2 (avg mass : 3246.9839 )
• Hex:7 HexNAc:6 dHex:2 NeuAc:3 (avg mass : 3538.2418 )
• Hex:7 HexNAc:6 dHex:3 (avg mass : 2810.6111 )
• Hex:7 HexNAc:6 dHex:4 (avg mass : 2956.7541 )
• Hex:7 HexNAc:6 dHex:5 (avg mass : 3102.8971 )
• Hex:7 HexNAc:6 dHex:6 (avg mass : 3249.0401 )
• Hex:8 HexNAc:3 NeuAc:1 (avg mass : 2215.9974 )
• Hex:8 HexNAc:6 dHex:1 NeuAc:1 (avg mass : 2971.7254 )
• Hex:8 HexNAc:7 NeuAc:1 (avg mass : 3028.7774 )
• Hex:8 HexNAc:7 dHex:1 (avg mass : 2883.6625 )
• Hex:12 HexNAc:2 (avg mass : 2370.1141 )

Disease

• Cancer, breast (DOID:1612)
• Carcinoma (DOID:305)
• Carcinoma, Hepatocellular (DOID:684)
• Esophageal cancer (DOID:5041)
• Oral squamous cell carcinoma (DOID:0050866)
• Prostate cancer (DOID:10283)

Reference

• Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies for Glycopeptide Analysis (2021 - Rebeca Kawahara, Kathirvel Alagesan, Marshall Bern, Meng Bo, Weiqian Cao, Robert J Chalkley, Kai Cheng, Matthew S. Choo, Nathan Edwards, Radoslav Goldman, Marcus Hoffmann, Yingwei Hu, Yifan Huang, Jin Young Kim, Doron Kletter, Benoit Liquet-Weiland, Mingqi Liu, Yehia Mechref, Sriram Neelamegham, Terry Nguyen-Khuong, Jonas Nilsson, Adam Pap, Gun Wook Park, Benjamin L. Parker, Cassandra L. Pegg, Josef M. Penninger, Toan K. Phung, Markus Pioch, Erdmann Rapp, Enes Sakalli, Miloslav Sanda, Benjamin L. Schulz, Nichollas Scott, Georgy Sofronov, Johannes Stadlmann, Sergey Vakhrushev, Christina Woo, Hung-Yi Wu, Pengyuan Yang, Wantao Ying, Zhang Yong, Hui Zhang, Jingfu Zhao, Joseph Zaia, Stuart M. Haslam, Giuseppe Palmisano, Jong Shin Yoo, Goran Larson, Kai-Hooi Khoo, Katalin F. Medzihradszky, Daniel Kolarich, Nicolle H. Packer, and Morten Thaysen-Andersen) / Status : Reviewed
• Quantitative Longitudinal Inventory of the N-Glycoproteome of Human Milk from a Single Donor Reveals the Highly Variable Repertoire and Dynamic Site-Specific Changes (2020 - Jing Zhu, Yu-Hsien Lin, Kelly A Dingess, Marko Mank, Bernd Stahl, Albert J R Heck) / Status : Reviewed
• Site-Specific Profiling of Serum Glycoproteins Using N-Linked Glycan and Glycosite Analysis Revealing Atypical N-Glycosylation Sites on Albumin and α-1B-Glycoprotein (2018 - Shisheng Sun, Yingwei Hu, Li Jia, Shadi Toghi Eshghi, Yang Liu, Punit Shah, Hui Zhang) / Status : Unreviewed
• Tongue Cancer Patients Can be Distinguished from Healthy Controls by Specific N-Glycopeptides Found in Serum. (2018 - Mayank Saraswat, Antti Mäkitie, Tiialotta Tohmola, Amy Dickinson, Shruti Saraswat, Sakari Joenväärä, Suvi Renkonen) / Status : Reviewed
• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Large-scale intact glycopeptide identification by Mascot database search (2018 - Ravi Chand Bollineni, Christian Jeffrey Koehler, Randi Elin Gislefoss, Jan Haug Anonsen, Bernd Thiede) / Status : Unreviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Comparison of sialylated N-glycopeptide levels in serum of pancreatic cancer patients, acute pancreatitis patients, and healthy controls (2014 - Kontro H, Joenväärä S, Haglund C, Renkonen R) / Status : Reviewed
• Protein and Site Specificity of Fucosylation in Liver-Secreted Glycoproteins (2014 - Pompach P, Ashline DJ, Brnakova Z, Benicky J, Sanda M, Goldman R.) / Status : Reviewed
• Selective glycopeptide profiling by acetone enrichment and LC/MS (2014 - Takakura D, Harazono A, Hashii N, Kawasaki N) / Status : Reviewed
• Computational framework for identification of intact glycopeptides in complex samples (2014 - Mayampurath A, Yu CY, Song E, Balan J, Mechref Y, Tang H.) / Status : Reviewed
• Quantitative analysis of site-specific N-glycans on sera haptoglobin β chain in liver diseases. (2013 - Zhang S, Jiang K, Sun C, Lu H, Liu Y.) / Status : Reviewed
• Exploring site-specific N-glycosylation microheterogeneity of haptoglobin using glycopeptide CID tandem mass spectra and glycan database search (2013 - Chandler KB1, Pompach P, Goldman R, Edwards N.) / Status : Reviewed
• Enrichment of glycopeptides for glycan structure and attachment site identification (2009 - Nilsson J, Rüetschi U, Halim A, Hesse C, Carlsohn E, Brinkmalm G, Larson G.) / Status : Reviewed
• Simultaneous glycosylation analysis of human serum glycoproteins by high-performance liquid chromatography/tandem mass spectrometry (2008 - Harazono A, Kawasaki N, Itoh S, Hashii N, Matsuishi-Nakajima Y, Kawanishi T, Yamaguchi T) / Status : Reviewed

Reported glycosite

• Haptoglobin / Homo sapiens
  •        Asn-181
  •        Asn-184
  •        Asn-207
  •        Asn-211
  •        Asn-241

Mass spectrometry observed peptide

• VSHHNLTTGATLINEQWLLTTAK (23aa)
  •    P00738    Asn-184     Haptoglobin / Homo sapiens
• MVSHHNLTTGATL (13aa)
  •    P00738    Asn-184     Haptoglobin / Homo sapiens
• MVSHHNLTTGATLINEQWLLTTAK (24aa)
  •    P00738    Asn-181     Haptoglobin / Homo sapiens
  •    P00738    Asn-184     Haptoglobin / Homo sapiens
• MVSHHNITTGATIINEQWIITTAK (24aa)
  •    P00738    Asn-184     Haptoglobin / Homo sapiens
• MVSHHNLTTGATLIN (15aa)
  •    P00738    Asn-184     Haptoglobin / Homo sapiens
• KMVSHHNLTTGATLINEQWLLTTAKN (26aa)
  •    P00738    Asn-184     Haptoglobin / Homo sapiens
• NLFLNHS (7aa)
  •    P00738    Asn-207     Haptoglobin / Homo sapiens
• NLFLNHSENATAK (13aa)
  •    P00738    Asn-211     Haptoglobin / Homo sapiens
  •    P00738    Asn-207     Haptoglobin / Homo sapiens
• LFLNHSENATAK (12aa)
  •    P00738    Asn-207     Haptoglobin / Homo sapiens
• NLFLNHSENATAKDIAPTLTLYVGKK (26aa)
  •    P00738    Asn-211     Haptoglobin / Homo sapiens
• NLFLNHSENAT (11aa)
  •    P00738    Asn-211     Haptoglobin / Homo sapiens
  •    P00738    Asn-207     Haptoglobin / Homo sapiens
• KNLFLNHSENATAKD (15aa)
  •    P00738    Asn-211     Haptoglobin / Homo sapiens
  •    P00738    Asn-207     Haptoglobin / Homo sapiens
• NIFINHSENATAK (13aa)
  •    P00738    Asn-211     Haptoglobin / Homo sapiens
  •    P00738    Asn-207     Haptoglobin / Homo sapiens
• VVLHPNYSQVDIGLIK (16aa)
  •    P00738    Asn-241     Haptoglobin / Homo sapiens
• VVLHPNYSQVDIGLIKLK (18aa)
  •    P00738    Asn-241     Haptoglobin / Homo sapiens
• VLHPNYSQVDIGLIK (15aa)
  •    P00738    Asn-241     Haptoglobin / Homo sapiens
• QLVEIEKVVLHPNYSQVDIGLIK (23aa)
  •    P00738    Asn-241     Haptoglobin / Homo sapiens
• QLVEIEKVVLHPNYSQVDIGLIKLK (25aa)
  •    P00738    Asn-241     Haptoglobin / Homo sapiens
• KVVLHPNYSQVDIGLIKL (18aa)
  •    P00738    Asn-241     Haptoglobin / Homo sapiens
• KQLVEIEKVVLHPNYSQVDIGLIK (24aa)
  •    P00738    Asn-241     Haptoglobin / Homo sapiens
• VVIHPNYSQVDIGIIK (16aa)
  •    P00738    Asn-241     Haptoglobin / Homo sapiens