GlyConnect

Taxonomy (1) Protein (1) Source (2) Structure (0) Composition (17) Disease (1) Site (8) Peptide (8)

Taxonomy

Homo sapiens (Human)

Protein

Lysosomal alpha-glucosidase / Homo sapiens P10253

Source

Reported structure

Composition

Disease

Cancer, breast (DOID:1612)

Reported glycosite

Lysosomal alpha-glucosidase / Homo sapiens :
- Undefined site
- Asn-140
- Asn-233
- Asn-390
- Asn-470
- Asn-652
- Asn-882
- Asn-925

Mass spectrometry validated peptide

IENISSSEMGYTATITR (17aa)
- P10253 Asn-140
VLLNTTVAPL (10aa)
- P10253 Asn-233
QVVENMTR (8aa)
- P10253 Asn-390
GVFITNETGQPIIGK (15aa)
- P10253 Asn-470
RGVFITNETGQPIIGK (16aa)
- P10253 Asn-470
GVPLVGADVCGFLGNTSEELCVR (23aa)
- P10253 Asn-652
NNTIVNEIVR (10aa)
- P10253 Asn-882
VTVIGVATAPQQVISNGVPVSNFTYSPDTK (30aa)
- P10253 Asn-925

- Hex:5 HexNAc:2 (avg mass : 1235.1173 )
- Hex:4 HexNAc:3 NeuAc:1 (avg mass : 1567.4278 )
- Hex:5 HexNAc:3 NeuAc:1 (avg mass : 1729.5702 )
- Hex:6 HexNAc:2 (avg mass : 1397.2597 )
- Hex:6 HexNAc:3 NeuAc:1 (avg mass : 1891.7126 )
- Hex:3 HexNAc:2 (avg mass : 910.8325 )
- Hex:3 HexNAc:2 dHex:1 (avg mass : 1056.9755 )
- Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )
- Hex:4 HexNAc:2 (avg mass : 1072.9749 )
- Hex:6 HexNAc:3 dHex:1 (avg mass : 1746.5977 )
- Hex:7 HexNAc:2 (avg mass : 1559.4021 )
- Hex:5 HexNAc:3 (avg mass : 1438.3123 )
- Hex:5 HexNAc:2 dHex:1 (avg mass : 1381.2603 )
- Hex:6 HexNAc:3 (avg mass : 1600.4547 )
- Hex:3 HexNAc:3 (avg mass : 1114.0275 )
- Hex:9 HexNAc:2 (avg mass : 1883.6869 )
- Hex:3 HexNAc:3 dHex:2 (avg mass : 1406.3135 )

Protein and gene references

UniProtKB : P10253

neXtProt : NX_P10253

GeneCards : GAA

GlycoDomain : P10253

3D structure from PDB

Select a PDB entry

Github Wiki

3D visualization by LiteMol

References (2)

Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018)
Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang
Pubmed : 29741879 DOI : 10.1021/acs.analchem.8b01137
Status : Unreviewed

Glycoproteomic analysis of the secretome of human endothelial cells (2013)
Yin X, Bern M, Xing Q, Ho J, Viner R, Mayr M.
Pubmed : 23345538 DOI : 10.1074/mcp.M112.024018
Status : Reviewed