Interleukin-6 receptor subunit beta

Taxonomy

• Homo sapiens (Human)

Protein

• Interleukin-6 receptor subunit beta / Homo sapiens    P40189

Source

• Blood Serum (UBERON_0001977)  
• Mammary Gland (UBERON_0001911)  
• Umbilical Vein (UBERON_0002066)   Endothelial Cell of Umbilical Vein (CL_0002618)  

Reported structure

Composition

• Hex:1 HexNAc:2 (avg mass : 586.5477 )
• Hex:4 HexNAc:4 (avg mass : 1479.3649 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:2 (avg mass : 2370.1661 )
• Hex:5 HexNAc:4 dHex:2 NeuAc:2 (avg mass : 2516.3091 )
• Hex:6 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2241.0506 )
• Hex:6 HexNAc:5 NeuAc:1 (avg mass : 2298.1026 )
• Hex:6 HexNAc:5 NeuAc:2 (avg mass : 2589.3605 )
• Hex:6 HexNAc:5 dHex:1 NeuAc:1 (avg mass : 2444.2456 )
• Hex:6 HexNAc:5 dHex:2 NeuAc:2 (avg mass : 2881.6465 )
• Hex:6 HexNAc:5 dHex:2 NeuAc:3 (avg mass : 3172.9044 )
• Hex:6 HexNAc:6 NeuAc:2 (avg mass : 2792.5555 )
• Hex:6 HexNAc:6 dHex:1 NeuAc:3 (avg mass : 3229.9564 )
• Hex:6 HexNAc:6 dHex:2 NeuAc:2 (avg mass : 3084.8415 )
• Hex:6 HexNAc:6 dHex:3 NeuAc:2 (avg mass : 3230.9845 )
• Hex:9 HexNAc:2 (avg mass : 1883.6869 )

Disease

• Cancer, breast (DOID:1612)
• Prostate cancer (DOID:10283)

Reference

• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Large-scale intact glycopeptide identification by Mascot database search (2018 - Ravi Chand Bollineni, Christian Jeffrey Koehler, Randi Elin Gislefoss, Jan Haug Anonsen, Bernd Thiede) / Status : Unreviewed
• Glycoproteomic analysis of the secretome of human endothelial cells (2013 - Yin X, Bern M, Xing Q, Ho J, Viner R, Mayr M.) / Status : Reviewed

Reported glycosite

• Interleukin-6 receptor subunit beta / Homo sapiens
  •        Asn-83
  •        Asn-131
  •        Asn-157
  •        Asn-246
  •        Asn-379
  •        Asn-390
  •        Asn-553
  •        Asn-687
  •        Asn-818

Mass spectrometry observed peptide

• EQYTIINR (8aa)
  •    P40189    Asn-83     Interleukin-6 receptor subunit beta / Homo sapiens
• NLSCIVNEGK (10aa)
  •    P40189    Asn-131     Interleukin-6 receptor subunit beta / Homo sapiens
• ETHLETNFTLK (11aa)
  •    P40189    Asn-157     Interleukin-6 receptor subunit beta / Homo sapiens
• LTWTNPSIK (9aa)
  •    P40189    Asn-246     Interleukin-6 receptor subunit beta / Homo sapiens
• SHLQNYTVNATK (12aa)
  •    P40189    Asn-379     Interleukin-6 receptor subunit beta / Homo sapiens
• LTVNLTNDR (9aa)
  •    P40189    Asn-390     Interleukin-6 receptor subunit beta / Homo sapiens
• NYTIFYR (7aa)
  •    P40189    Asn-553     Interleukin-6 receptor subunit beta / Homo sapiens
• DQMYSDGNFTDVSVVEIEANDK (22aa)
  •    P40189    Asn-687     Interleukin-6 receptor subunit beta / Homo sapiens