A disintegrin and metalloproteinase with thrombospondin motifs (13adamts13)

Taxonomy

• Homo sapiens (Human)

Protein

• A disintegrin and metalloproteinase with thrombospondin motifs (13adamts13) / Homo sapiens    Q76LX8

Source

• Blood Plasma (UBERON_0001969)  
• Blood Serum (UBERON_0001977)  

Reported structure

• O-Linked / O-Fuc / Fuc

Composition

• dHex:1 (avg mass : 164.1583 )
• Hex:1 (avg mass : 180.1577 )
• Hex:5 HexNAc:4 NeuAc:1 (avg mass : 1932.7652 )
• Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:2 (avg mass : 2370.1661 )
• Hex:6 HexNAc:4 dHex:2 NeuAc:1 (avg mass : 2387.1936 )
• Hex:6 HexNAc:5 NeuAc:3 (avg mass : 2880.6184 )
• Hex:6 HexNAc:5 dHex:1 NeuAc:3 (avg mass : 3026.7614 )
• Hex:6 HexNAc:5 dHex:2 NeuAc:2 (avg mass : 2881.6465 )
• Hex:6 HexNAc:6 NeuAc:2 (avg mass : 2792.5555 )
• Hex:7 HexNAc:6 dHex:2 NeuAc:1 (avg mass : 2955.726 )

Disease

• Prostate cancer (DOID:10283)

Reference

• Large-scale intact glycopeptide identification by Mascot database search (2018 - Ravi Chand Bollineni, Christian Jeffrey Koehler, Randi Elin Gislefoss, Jan Haug Anonsen, Bernd Thiede) / Status : Unreviewed
• Identification of N-linked glycosylation and putative O-fucosylation, C-mannosylation sites in plasma derived ADAMTS13 (2014 - Sorvillo N, Kaijen PH, Matsumoto M, Fujimura Y, van der Zwaan C, Verbij FC, Pos W, Fijnheer R, Voorberg J, Meijer AB) / Status : Reviewed

Reported glycosite

• A disintegrin and metalloproteinase with thrombospondin motifs (13adamts13) / Homo sapiens
  •        Trp-390
  •        Asn-552
  •        Asn-614
  •        Ser-698
  •        Asn-707
  •        Trp-884
  •        Ser-907
  •        Ser-1087
  •        Asn-1235
  •        Asn-1345

Mass spectrometry observed peptide

• CQVCGGDNSTCSPR (14aa)
  •    Q76LX8    Asn-552     A disintegrin and metalloproteinase with thrombospondin motifs (13adamts13) / Homo sapiens
• MSISPNTTYPSLLEDGR (17aa)
  •    Q76LX8    Asn-614     A disintegrin and metalloproteinase with thrombospondin motifs (13adamts13) / Homo sapiens
• WVNYSCLDQAR (11aa)
  •    Q76LX8    Asn-707     A disintegrin and metalloproteinase with thrombospondin motifs (13adamts13) / Homo sapiens
• VLESSLNCSAGDMLLLWGR (19aa)
  •    Q76LX8    Asn-1235     A disintegrin and metalloproteinase with thrombospondin motifs (13adamts13) / Homo sapiens
• IAIHALATNMGAGTEGANASYILIR (25aa)
  •    Q76LX8    Asn-1345     A disintegrin and metalloproteinase with thrombospondin motifs (13adamts13) / Homo sapiens