Myeloperoxidase

Taxonomy

• Homo sapiens (Human)

Protein

• Myeloperoxidase / Homo sapiens    P05164

Source

• Blood Serum (UBERON_0001977)  
• Mammary Gland (UBERON_0001911)  
• Milk (UBERON_0001913)  
• Urine (UBERON_0001088)  

Reported structure

• N-Linked / High-Mannose / Man(a1-3)[Man(a1-6)]Man(a1-6)[Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / High-Mannose / Man(a1-3)[Man(a1-6)]Man(a1-6)[Man(a1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / High-Mannose / Structure 314
• N-Linked / Pauci-Mannose / Man(a1-3)[Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc

Composition

• Hex:2 HexNAc:2 dHex:1 NeuAc:2 (avg mass : 1477.3489 )
• Hex:3 HexNAc:2 (avg mass : 910.8325 )
• Hex:3 HexNAc:2 dHex:1 (avg mass : 1056.9755 )
• Hex:3 HexNAc:3 dHex:1 (avg mass : 1260.1705 )
• Hex:3 HexNAc:4 dHex:1 (avg mass : 1463.3655 )
• Hex:4 HexNAc:3 dHex:1 (avg mass : 1422.3129 )
• Hex:4 HexNAc:3 dHex:1 NeuAc:1 (avg mass : 1713.5708 )
• Hex:5 HexNAc:2 (avg mass : 1235.1173 )
• Hex:5 HexNAc:2 dHex:1 (avg mass : 1381.2603 )
• Hex:5 HexNAc:3 (avg mass : 1438.3123 )
• Hex:5 HexNAc:4 NeuAc:1 (avg mass : 1932.7652 )
• Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:2 (avg mass : 2370.1661 )
• Hex:5 HexNAc:4 dHex:2 NeuAc:1 (avg mass : 2225.0512 )
• Hex:5 HexNAc:4 dHex:2 NeuAc:2 (avg mass : 2516.3091 )
• Hex:6 HexNAc:2 (avg mass : 1397.2597 )
• Hex:6 HexNAc:5 NeuAc:1 (avg mass : 2298.1026 )
• Hex:6 HexNAc:5 NeuAc:2 (avg mass : 2589.3605 )
• Hex:6 HexNAc:5 NeuAc:3 (avg mass : 2880.6184 )
• Hex:6 HexNAc:5 dHex:1 NeuAc:2 (avg mass : 2735.5035 )
• Hex:6 HexNAc:5 dHex:1 NeuAc:3 (avg mass : 3026.7614 )
• Hex:6 HexNAc:6 NeuAc:2 (avg mass : 2792.5555 )
• Hex:7 HexNAc:2 (avg mass : 1559.4021 )
• Hex:7 HexNAc:6 NeuAc:2 NeuGc:2 (avg mass : 3569.2125 )
• Hex:7 HexNAc:6 dHex:1 (avg mass : 2518.3251 )
• Hex:7 HexNAc:6 dHex:3 NeuAc:1 (avg mass : 3101.869 )

Disease

• Cancer, breast (DOID:1612)
• Prostate cancer (DOID:10283)

Reference

• Quantitative Longitudinal Inventory of the N-Glycoproteome of Human Milk from a Single Donor Reveals the Highly Variable Repertoire and Dynamic Site-Specific Changes (2020 - Jing Zhu, Yu-Hsien Lin, Kelly A Dingess, Marko Mank, Bernd Stahl, Albert J R Heck) / Status : Reviewed
• Site-Specific Profiling of Serum Glycoproteins Using N-Linked Glycan and Glycosite Analysis Revealing Atypical N-Glycosylation Sites on Albumin and α-1B-Glycoprotein (2018 - Shisheng Sun, Yingwei Hu, Li Jia, Shadi Toghi Eshghi, Yang Liu, Punit Shah, Hui Zhang) / Status : Unreviewed
• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Large-scale intact glycopeptide identification by Mascot database search (2018 - Ravi Chand Bollineni, Christian Jeffrey Koehler, Randi Elin Gislefoss, Jan Haug Anonsen, Bernd Thiede) / Status : Unreviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8 A resolution. (2000 - Fiedler T, Davey C, Fenna R) / Status : Reviewed

Reported glycosite

• Myeloperoxidase / Homo sapiens
  •        Ser-322
  •        Asn-323
  •        Asn-355
  •        Asn-391
  •        Ser-481
  •        Asn-483
  •        Asn-729

Mass spectrometry observed peptide

• SCPACPGSNITIR (13aa)
  •    P05164    Ser-322     Myeloperoxidase / Homo sapiens
  •    P05164    Asn-323     Myeloperoxidase / Homo sapiens
• RNLRNMSNQLGLLAVNQRF (19aa)
  •    P05164    Asn-355     Myeloperoxidase / Homo sapiens
• RNMSNQLGLLAVNQRF (16aa)
  •    P05164    Asn-355     Myeloperoxidase / Homo sapiens
• NMSNQLGLLAVNQR (14aa)
  •    P05164    Asn-355     Myeloperoxidase / Homo sapiens
• NLRNMSNQLGLLAVNQR (17aa)
  •    P05164    Asn-355     Myeloperoxidase / Homo sapiens
• AIIPFDNIHDDPCIITNR (18aa)
  •    P05164    Asn-391     Myeloperoxidase / Homo sapiens
• ALLPFDNLHDDPCLLTNRSAR (21aa)
  •    P05164    Asn-391     Myeloperoxidase / Homo sapiens
• ALLPFDNLHDDPCLLTNR (18aa)
  •    P05164    Asn-391     Myeloperoxidase / Homo sapiens
• SYNDSVDPR (9aa)
  •    P05164    Asn-483     Myeloperoxidase / Homo sapiens
  •    P05164    Ser-481     Myeloperoxidase / Homo sapiens
• DFVNCSTLPALNLASWR (17aa)
  •    P05164    Asn-729     Myeloperoxidase / Homo sapiens