Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Body Fluid (UBERON_0006314)  
• Blood Serum (UBERON_0001977)  

Reported structure

• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-2)Man(a1-3)[Gal(b1-4)GlcNAc(b1-2)Man(a1-6)][GlcNAc(b1-4)]Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

• Hex:5 HexNAc:5 (avg mass : 1844.7023 )

Disease

• Carcinoma, Gallbladder which metastasises to the liver (DOID:4948)
• Carcinoma, Hepatocellular (DOID:684)

Reference

• Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans. (1993 - Aoyagi Y, Suzuki Y, Igarashi K, Saitoh A, Oguro M, Yokota T, Mori S, Suda T, Isemura M, Asakura H) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Undefined site

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Endothelial Cell of Umbilical Vein (CL_0002618)  

Reported structure

Composition

• Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )

Disease

Reference

• Glycoproteomic analysis of the secretome of human endothelial cells (2013 - Yin X, Bern M, Xing Q, Ho J, Viner R, Mayr M.) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Undefined site

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Hep-G2 (CVCL_0027)   Liver (UBERON_0002107)  

Reported structure

• N-Linked / Complex / NeuAc(a2-6)Gal(b1-4)[Fuc(a1-?)]GlcNAc(b1-2)Man(a1-?)[NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc

Composition

• Hex:5 HexNAc:4 dHex:2 NeuAc:2 (avg mass : 2516.3091 )

Disease

• Carcinoma, Hepatocellular (DOID:684)

Reference

• Human alpha-fetoprotein produced from Hep G2 cell line: structure and heterogeneity of the oligosaccharide moiety. (1995 - Ferranti P, Pucci P, Marino G, Fiume I, Terrana B, Ceccarini C, Malorni A) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Undefined site

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Hep-G2 (CVCL_0027)   Liver (UBERON_0002107)  

Reported structure

• N-Linked / Complex / NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-3)[NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

• Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )

Disease

• Carcinoma, Hepatocellular (DOID:684)

Reference

• Human alpha-fetoprotein produced from Hep G2 cell line: structure and heterogeneity of the oligosaccharide moiety. (1995 - Ferranti P, Pucci P, Marino G, Fiume I, Terrana B, Ceccarini C, Malorni A) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Undefined site

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Body Fluid (UBERON_0006314)  
• Blood Serum (UBERON_0001977)  

Reported structure

• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-2)[Gal(b1-4)GlcNAc(b1-4)]Man(a1-3)[Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc

Composition

• Hex:6 HexNAc:5 dHex:1 (avg mass : 2152.9877 )

Disease

• Carcinoma, Gallbladder which metastasises to the liver (DOID:4948)
• Carcinoma, Hepatocellular (DOID:684)

Reference

• Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans. (1993 - Aoyagi Y, Suzuki Y, Igarashi K, Saitoh A, Oguro M, Yokota T, Mori S, Suda T, Isemura M, Asakura H) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Undefined site

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Body Fluid (UBERON_0006314)  
• Blood Serum (UBERON_0001977)  

Reported structure

• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-2)Man(a1-3)[Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc

Composition

• Hex:5 HexNAc:4 dHex:1 (avg mass : 1787.6503 )

Disease

• Carcinoma, Gallbladder which metastasises to the liver (DOID:4948)
• Carcinoma, Hepatocellular (DOID:684)

Reference

• Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans. (1993 - Aoyagi Y, Suzuki Y, Igarashi K, Saitoh A, Oguro M, Yokota T, Mori S, Suda T, Isemura M, Asakura H) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Undefined site

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Body Fluid (UBERON_0006314)  
• Blood Serum (UBERON_0001977)  

Reported structure

• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-2)Man(a1-3)[Gal(b1-4)GlcNAc(b1-2)Man(a1-6)][GlcNAc(b1-4)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc

Composition

• Hex:5 HexNAc:5 dHex:1 (avg mass : 1990.8453 )

Disease

• Carcinoma, Gallbladder which metastasises to the liver (DOID:4948)
• Carcinoma, Hepatocellular (DOID:684)

Reference

• Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans. (1993 - Aoyagi Y, Suzuki Y, Igarashi K, Saitoh A, Oguro M, Yokota T, Mori S, Suda T, Isemura M, Asakura H) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Undefined site

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Body Fluid (UBERON_0006314)  
• Blood Serum (UBERON_0001977)  

Reported structure

• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-2)Man(a1-3)[Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

• Hex:5 HexNAc:4 (avg mass : 1641.5073 )

Disease

• Carcinoma, Gallbladder which metastasises to the liver (DOID:4948)
• Carcinoma, Hepatocellular (DOID:684)

Reference

• Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans. (1993 - Aoyagi Y, Suzuki Y, Igarashi K, Saitoh A, Oguro M, Yokota T, Mori S, Suda T, Isemura M, Asakura H) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Undefined site

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Hep-G2 (CVCL_0027)   Liver (UBERON_0002107)  

Reported structure

• N-Linked / Complex / NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-3)[NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc

Composition

• Hex:5 HexNAc:4 dHex:1 NeuAc:2 (avg mass : 2370.1661 )

Disease

• Carcinoma, Hepatocellular (DOID:684)

Reference

• Human alpha-fetoprotein produced from Hep G2 cell line: structure and heterogeneity of the oligosaccharide moiety. (1995 - Ferranti P, Pucci P, Marino G, Fiume I, Terrana B, Ceccarini C, Malorni A) / Status : Reviewed
• Unique structure of glycopeptide from alpha-fetoprotein produced in human hepatoma cell line, as determined by 1H-nuclear magnetic resonance spectroscopy. (1990 - Terrana B, Tecce M, Manetti R, Ceccarini C, Lamba D, Segre A) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Undefined site

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Body Fluid (UBERON_0006314)  
• Blood Serum (UBERON_0001977)  

Reported structure

• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-2)[Gal(b1-4)GlcNAc(b1-4)]Man(a1-3)[Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

• Hex:6 HexNAc:5 (avg mass : 2006.8447 )

Disease

• Carcinoma, Gallbladder which metastasises to the liver (DOID:4948)
• Carcinoma, Hepatocellular (DOID:684)

Reference

• Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans. (1993 - Aoyagi Y, Suzuki Y, Igarashi K, Saitoh A, Oguro M, Yokota T, Mori S, Suda T, Isemura M, Asakura H) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Undefined site

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Endothelial Cell of Umbilical Vein (CL_0002618)  

Reported structure

Composition

• Hex:4 HexNAc:2 dHex:1 (avg mass : 1219.1179 )

Disease

Reference

• Glycoproteomic analysis of the secretome of human endothelial cells (2013 - Yin X, Bern M, Xing Q, Ho J, Viner R, Mayr M.) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Undefined site

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Blood Serum (UBERON_0001977)  

Reported structure

• N-Linked / Complex / NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-2)Man(a1-6)[NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc

Composition

• Hex:5 HexNAc:4 dHex:1 NeuAc:2 (avg mass : 2370.1661 )

Disease

Reference

• Sugar chains of human cord serum alpha-fetoprotein: characteristics of N-linked sugar chains of glycoproteins produced in human liver and hepatocellular carcinomas. (1993 - Yamashita K, Taketa K, Nishi S, Fukushima K, Ohkura T) / Status : Reviewed
• Characterization of E-PHA-reactive alpha-fetoprotein isoforms by two-dimensional lectin affinity electrophoresis. (1993 - Taketa K, Fujii Y, Taga H) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Asn-251

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Blood Serum (UBERON_0001977)  

Reported structure

• N-Linked / Complex / NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-6)[Gal(b1-4)GlcNAc(b1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc

Composition

• Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )

Disease

Reference

• Characterization of E-PHA-reactive alpha-fetoprotein isoforms by two-dimensional lectin affinity electrophoresis. (1993 - Taketa K, Fujii Y, Taga H) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Asn-251

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Blood Serum (UBERON_0001977)  

Reported structure

• N-Linked / Complex / NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-6)[GlcNAc(b1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc

Composition

• Hex:4 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 1916.7658 )

Disease

Reference

• Characterization of E-PHA-reactive alpha-fetoprotein isoforms by two-dimensional lectin affinity electrophoresis. (1993 - Taketa K, Fujii Y, Taga H) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Asn-251

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Blood Serum (UBERON_0001977)  

Reported structure

• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-2)Man(a1-6)[GlcNAc(b1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

• Hex:4 HexNAc:4 (avg mass : 1479.3649 )

Disease

Reference

• Characterization of E-PHA-reactive alpha-fetoprotein isoforms by two-dimensional lectin affinity electrophoresis. (1993 - Taketa K, Fujii Y, Taga H) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Asn-251

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Blood Serum (UBERON_0001977)  

Reported structure

• N-Linked / Complex / NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-6)[GlcNAc(b1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

• Hex:4 HexNAc:4 NeuAc:1 (avg mass : 1770.6228 )

Disease

Reference

• Characterization of E-PHA-reactive alpha-fetoprotein isoforms by two-dimensional lectin affinity electrophoresis. (1993 - Taketa K, Fujii Y, Taga H) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Asn-251

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Blood Serum (UBERON_0001977)  

Reported structure

• N-Linked / Complex / NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-3)[GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

• Hex:4 HexNAc:4 NeuAc:1 (avg mass : 1770.6228 )

Disease

Reference

• Characterization of E-PHA-reactive alpha-fetoprotein isoforms by two-dimensional lectin affinity electrophoresis. (1993 - Taketa K, Fujii Y, Taga H) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Asn-251

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Blood Serum (UBERON_0001977)  

Reported structure

• N-Linked / Complex / NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-2)Man(a1-6)[Gal(b1-4)GlcNAc(b1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc

Composition

• Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )

Disease

Reference

• Characterization of E-PHA-reactive alpha-fetoprotein isoforms by two-dimensional lectin affinity electrophoresis. (1993 - Taketa K, Fujii Y, Taga H) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Asn-251

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Blood Serum (UBERON_0001977)  

Reported structure

• N-Linked / Complex / NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-2)Man(a1-6)[NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

• Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )

Disease

Reference

• Sugar chains of human cord serum alpha-fetoprotein: characteristics of N-linked sugar chains of glycoproteins produced in human liver and hepatocellular carcinomas. (1993 - Yamashita K, Taketa K, Nishi S, Fukushima K, Ohkura T) / Status : Reviewed
• Characterization of E-PHA-reactive alpha-fetoprotein isoforms by two-dimensional lectin affinity electrophoresis. (1993 - Taketa K, Fujii Y, Taga H) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Asn-251

Mass spectrometry validated peptide

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-fetoprotein / Homo sapiens    P02771

Source

• Blood Serum (UBERON_0001977)  

Reported structure

• N-Linked / Complex / NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-2)Man(a1-6)[Gal(b1-4)GlcNAc(b1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

• Hex:5 HexNAc:4 NeuAc:1 (avg mass : 1932.7652 )

Disease

Reference

• Characterization of E-PHA-reactive alpha-fetoprotein isoforms by two-dimensional lectin affinity electrophoresis. (1993 - Taketa K, Fujii Y, Taga H) / Status : Reviewed

Reported glycosite

• Alpha-fetoprotein / Homo sapiens :
  •        Asn-251

Mass spectrometry validated peptide