Recombinant Mucin-1 Muc1f/4tr

Taxonomy

• Homo sapiens (Human)

Protein

• Recombinant Mucin-1 Muc1f/4tr / Homo sapiens    P15941    Q99102

Source

• Colon (UBERON_0001155)   Caco-2 (CVCL_0025)  
• Milk (UBERON_0001913)  

Reported structure

• N-Linked / Complex / Gal(?1-?)GlcNAc(?1-?)Man(a1-3)[Gal(?1-?)GlcNAc(?1-?)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / Structure 1523
• N-Linked / Complex / Structure 9425
• N-Linked / Complex / Structure 1519
• N-Linked / Complex / Structure 9372
• N-Linked / Complex / Structure 9499
• N-Linked / Complex / Structure 9443
• O-Linked / Core 1 / Gal(b1-3)GalNAc
• O-Linked / Core 1 / Fuc(a1-2)Gal(b1-3)GalNAc
• O-Linked / Core 1 / Gal(b1-3)GalNAc+"+ NeuAc(a2-?)"
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc+"+ Fuc(a1-2)"
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc+"+ NeuAc(a2-?)"
• O-Linked / Undefined core / Gal(b1-3)GalNAc+"+ GlcNAc(?1-?)"
• O-Linked / Undefined core / Gal(b1-3)GalNAc+"+ 2 x Gal(b1-4)GlcNAc(b1-?)"

Composition

• Hex:1 HexNAc:1 (avg mass : 383.3527 )
• Hex:1 HexNAc:1 NeuAc:1 (avg mass : 674.6106 )
• Hex:1 HexNAc:1 dHex:1 (avg mass : 529.4957 )
• Hex:1 HexNAc:2 (avg mass : 586.5477 )
• Hex:2 HexNAc:2 (avg mass : 748.6901 )
• Hex:2 HexNAc:2 NeuAc:1 (avg mass : 1039.948 )
• Hex:2 HexNAc:2 dHex:1 (avg mass : 894.8331 )
• Hex:3 HexNAc:3 (avg mass : 1114.0275 )
• Hex:5 HexNAc:4 dHex:1 (avg mass : 1787.6503 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:2 (avg mass : 2370.1661 )
• Hex:5 HexNAc:4 dHex:2 NeuAc:1 (avg mass : 2225.0512 )
• Hex:5 HexNAc:4 dHex:3 NeuAc:1 (avg mass : 2371.1942 )
• Hex:6 HexNAc:5 dHex:1 NeuAc:1 (avg mass : 2444.2456 )
• Hex:7 HexNAc:6 dHex:1 (avg mass : 2518.3251 )

Disease

• Adenocarcinoma (DOID:299)

Reference

• Quantitative Longitudinal Inventory of the N-Glycoproteome of Human Milk from a Single Donor Reveals the Highly Variable Repertoire and Dynamic Site-Specific Changes (2020 - Jing Zhu, Yu-Hsien Lin, Kelly A Dingess, Marko Mank, Bernd Stahl, Albert J R Heck) / Status : Reviewed
• In vivo glycosylation of mucin tandem repeats (2001 - Silverman, Parry, Sutton-Smith, Burdick, McDermott, Reid, Batra, Morris, Hollingsworth, Dell, Harris) / Status : Reviewed

Reported glycosite

• Recombinant Mucin-1 Muc1f/4tr / Homo sapiens
  •        Undefined site
  •        Asn-1647
  •        Asn-1802
  •        Asn-2049

Mass spectrometry observed peptide

• KRNDQLPSNFTPVFYSQLQKN (21aa)
  •    Q99102    Asn-1647
  •    P15941    Asn-1647
• RTVVCHCNAESQCLYNQTSRV (21aa)
  •    Q99102    Asn-1802
  •    P15941    Asn-1802
• RDVTALNVSTLKA (13aa)
  •    Q99102    Asn-2049
  •    P15941    Asn-2049