GlyConnect

Taxonomy (1) Protein (1) Source (3) Structure (22) Composition (36) Disease (2) Site (2) Peptide (3)

Taxonomy

Homo sapiens (Human)

Protein

Metalloproteinase inhibitor 1 / Homo sapiens P01033

Source

Reported structure

Composition

Disease

Prostate cancer (DOID:10283)
Cancer, breast (DOID:1612)

Reported glycosite

Metalloproteinase inhibitor 1 / Homo sapiens :
- Asn-53
- Asn-101

Mass spectrometry validated peptide

FVGTPEVNQTTIYQR (15aa)
- P01033 Asn-53
FVGTPEVNQTTLYQR (15aa)
- P01033 Asn-53
SHNRSEEFLIAGK (13aa)
- P01033 Asn-101

- N-Linked / Complex (avg mass : 1463.3655 )
- N-Linked / Complex (avg mass : 2356.1827 )
- N-Linked / Complex (avg mass : 2119.9608 )
- N-Linked / Pauci-Mannose (avg mass : 1056.9755 )
- N-Linked / Complex (avg mass : 1828.7029 )
- N-Linked / Complex (avg mass : 1713.5708 )
- N-Linked / Complex (avg mass : 2282.1032 )
- N-Linked / Complex (avg mass : 1666.5605 )
- N-Linked / Complex (avg mass : 1260.1705 )
- N-Linked / Complex (avg mass : 2370.1661 )
- N-Linked / Complex (avg mass : 2735.5035 )
- N-Linked / Complex (avg mass : 1625.5079 )
- N-Linked / Complex (avg mass : 2444.2456 )
- N-Linked / Complex (avg mass : 1422.3129 )
- N-Linked / Complex (avg mass : 2078.9082 )
- N-Linked / Complex (avg mass : 2152.9877 )
- N-Linked / Complex (avg mass : 1990.8453 )
- N-Linked / No-core (avg mass : 367.3533 )
- N-Linked / Complex (avg mass : 1916.7658 )
- N-Linked / Complex (avg mass : 1787.6503 )
- N-Linked / Complex (avg mass : 2518.3251 )
- N-Linked / High-Mannose (avg mass : 1072.9749 )

- Hex:3 HexNAc:6 dHex:3 (avg mass : 2162.0415 )
- Hex:12 HexNAc:2 (avg mass : 2370.1141 )
- Hex:3 HexNAc:6 dHex:2 (avg mass : 2015.8985 )
- Hex:4 HexNAc:5 dHex:2 NeuAc:1 (avg mass : 2266.1038 )
- Hex:4 HexNAc:6 dHex:2 (avg mass : 2178.0409 )
- Hex:5 HexNAc:5 dHex:2 (avg mass : 2136.9883 )
- Hex:9 HexNAc:2 (avg mass : 1883.6869 )
- Hex:8 HexNAc:2 (avg mass : 1721.5445 )
- Hex:6 HexNAc:5 dHex:1 NeuAc:3 (avg mass : 3026.7614 )
- Hex:4 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 1916.7658 )
- Hex:5 HexNAc:4 dHex:3 NeuAc:1 (avg mass : 2371.1942 )
- Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )
- Hex:6 HexNAc:5 dHex:1 (avg mass : 2152.9877 )
- Hex:4 HexNAc:5 dHex:1 NeuAc:1 (avg mass : 2119.9608 )
- Hex:5 HexNAc:4 dHex:1 NeuAc:2 (avg mass : 2370.1661 )
- Hex:4 HexNAc:5 dHex:1 NeuAc:2 (avg mass : 2411.2187 )
- Hex:4 HexNAc:3 dHex:1 NeuAc:1 (avg mass : 1713.5708 )
- Hex:6 HexNAc:7 (avg mass : 2413.2347 )
- Hex:5 HexNAc:4 dHex:2 NeuAc:1 (avg mass : 2225.0512 )
- Hex:3 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 1754.6234 )

Protein and gene references

UniProtKB : P01033

neXtProt : NX_P01033

GeneCards : TIMP1

3D structure from PDB

Either no PDB or existing PDB of non-glycosylated form

References (3)

Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018)
Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang
Pubmed : 29741879 DOI : 10.1021/acs.analchem.8b01137
Status : Unreviewed

Distinct urinary glycoprotein signatures in prostate cancer patients (2018)
Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano
Pubmed : 30237853 DOI : 10.18632/oncotarget.26005
Status : Unreviewed

Site-specific characterization of glycoprotein carbohydrates by exoglycosidase digestion and laser desorption mass spectrometry. (1994)
Sutton C, O'Neill J, Cottrell J
Pubmed : 8053566
Status : Reviewed