Keratin, type II cytoskeletal 8

Taxonomy

• Homo sapiens (Human)

Protein

• Keratin, type II cytoskeletal 8 / Homo sapiens    P05787

Source

• Colon (UBERON_0001155)   HT-29 (CVCL_0320)  
• Mammary Gland (UBERON_0001911)  
• HeLa (CVCL_0030)  

Reported structure

• O-Linked / O-GlcNAc / GlcNAc(b

Composition

• HexNAc:1 (avg mass : 221.2103 )
• Hex:4 HexNAc:5 dHex:1 NeuAc:1 (avg mass : 2119.9608 )
• Hex:7 HexNAc:2 (avg mass : 1559.4021 )

Disease

• Adenocarcinoma, Grade II (DOID:299)
• Cancer, breast (DOID:1612)

Reference

• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Extensive Crosstalk Between O-GlcNAcylation and Phosphorylation Regulates Cytokinesis (2010 - Zihao Wang, Namrata D Udeshi, Chad Slawson, Philip D Compton, Kaoru Sakabe, Win D Cheung, Jeffrey Shabanowitz, Donald F Hunt, Gerald W Hart) / Status : Reviewed
• Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18. (1991 - Chou C, Smith A, Omary M) / Status : Reviewed

Reported glycosite

• Keratin, type II cytoskeletal 8 / Homo sapiens
  •        Undefined site
  •        Ser-13
  •        Ser-15
  •        Asn-408

Mass spectrometry observed peptide

• VSTSGPR (7aa)
  •    P05787    Ser-15     Keratin, type II cytoskeletal 8 / Homo sapiens
  •    P05787    Ser-13     Keratin, type II cytoskeletal 8 / Homo sapiens
• NMSIHTK (7aa)
  •    P05787    Asn-408     Keratin, type II cytoskeletal 8 / Homo sapiens