Keratin, type i cytoskeletal 18

Taxonomy

• Homo sapiens (Human)

Protein

• Keratin, type i cytoskeletal 18 / Homo sapiens    P05783

Source

• Colon (UBERON_0001155)   HT-29 (CVCL_0320)  
• Mammary Gland (UBERON_0001911)  
• Ovary (UBERON_0000992)   Sf9 (CVCL_0549)  

Reported structure

• O-Linked / Undefined core / GlcNAc

Composition

• HexNAc:1 (avg mass : 221.2103 )
• Hex:7 HexNAc:6 (avg mass : 2372.1821 )
• Hex:8 HexNAc:2 (avg mass : 1721.5445 )
• Hex:12 HexNAc:2 (avg mass : 2370.1141 )

Disease

• Adenocarcinoma, Grade II (DOID:299)
• Cancer, breast (DOID:1612)

Reference

• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Identification and mutational analysis of the glycosylation sites of human keratin 18. (1995 - Ku N, Omary M) / Status : Reviewed
• Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18. (1991 - Chou C, Smith A, Omary M) / Status : Reviewed

Reported glycosite

• Keratin, type i cytoskeletal 18 / Homo sapiens
  •        Ser-29
  •        Ser-30
  •        Ser-48
  •        Asn-423

Mass spectrometry observed peptide

• VVSETNDTK (9aa)
  •    P05783    Asn-423