Interferon alpha-2

Taxonomy

• Homo sapiens (Human)

Protein

• Interferon alpha-2 / Homo sapiens    P01563

Source

• Leukocyte (CL_0000738)  

Reported structure

• O-Linked / Core 1 / Gal(b1-3)[NeuAc(a2-6)]GalNAc
• O-Linked / Core 1 / NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc
• O-Linked / Undefined core / Gal(?1-?)GalNAc
• O-Linked / Undefined core / Gal(?1-?)GalNAc+"+ NeuAc"
• O-Linked / Undefined core / Gal(?1-?)GlcNAc(?1-?)[Gal(?1-?)]GalNAc
• O-Linked / Undefined core / Gal(?1-?)GalNAc+"+ 2 x NeuAc"

Composition

• Hex:1 HexNAc:1 (avg mass : 383.3527 )
• Hex:1 HexNAc:1 NeuAc:1 (avg mass : 674.6106 )
• Hex:1 HexNAc:1 NeuAc:2 (avg mass : 965.8685 )
• Hex:2 HexNAc:2 (avg mass : 748.6901 )
• Hex:2 HexNAc:2 NeuAc:1 (avg mass : 1039.948 )

Disease

Reference

• Structural characterisation of N-linked and O-linked oligosaccharides derived from interferon-alpha2b and interferon-alpha14c produced by Sendai-virus-induced human peripheral blood leukocytes (1998 - Nyman, Kalkkinen, Tolo, Helin) / Status : Reviewed
• Natural human interferon-alpha 2 is O-glycosylated. (1991 - Adolf G, Kalsner I, Ahorn H, Maurer-Fogy I, Cantell K) / Status : Reviewed

Reported glycosite

• Interferon alpha-2 / Homo sapiens
  •        Thr-129

Mass spectrometry observed peptide