GlyConnect

Taxonomy (1) Protein (1) Source (3) Structure (1) Composition (36) Disease (2) Site (6) Peptide (5)

Taxonomy

Homo sapiens (Human)

Protein

Protein AMBP / Homo sapiens P02760

Source

Reported structure

O-Linked / Undefined core / NeuAc(?2-?)Gal(?1-?)GalNAc(?1-?)GalNAc

Composition

Disease

Cancer, breast (DOID:1612)
Prostate cancer (DOID:10283)

Reported glycosite

Protein AMBP / Homo sapiens :
- Undefined site
- Thr-24
- Asn-115
- Asn-250
- Thr-252
- Thr-258

Mass spectrometry validated peptide

SKWNITMESY (10aa)
- P02760 Asn-115
SKWNITMESYVVHTNYDEYAIFITK (25aa)
- P02760 Asn-115
WNITMESYVVHTNYDEYAIFLTK (23aa)
- P02760 Asn-115
YFYNGTSMACETFQYGGCMGNGNNFVTEK (29aa)
- P02760 Asn-250
YFYNGTSMACETFQYGGCMGNGNNFVTEK (29aa)
- P02760 Thr-258
YFYNGTSMACETFQYGGCMGNGNNFVTEK (29aa)
- P02760 Thr-252
YFYNGTSMACETFQYGGCMGNGNNFVTEKECLQTCR (36aa)
- P02760 Thr-252

- O-Linked / Undefined core (avg mass : 877.8056 )

- Hex:11 HexNAc:11 NeuAc:1
- Hex:5 HexNAc:5 dHex:3 (avg mass : 2283.1313 )
- Hex:6 HexNAc:5 NeuAc:1 (avg mass : 2298.1026 )
- Hex:3 HexNAc:5 (avg mass : 1520.4175 )
- Hex:6 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2241.0506 )
- Hex:6 HexNAc:6 dHex:1 (avg mass : 2356.1827 )
- Hex:5 HexNAc:4 NeuGc:1 (avg mass : 1948.7646 )
- Hex:3 HexNAc:3 dHex:1 NeuAc:1 (avg mass : 1551.4284 )
- Hex:4 HexNAc:5 NeuGc:1
- Hex:8 HexNAc:5 (avg mass : 2331.1295 )
- Hex:3 HexNAc:3 dHex:2 NeuAc:2 (avg mass : 1988.8293 )
- Hex:3 HexNAc:6 dHex:2 NeuAc:1 (avg mass : 2307.1564 )
- Hex:5 HexNAc:4 dHex:2 (avg mass : 1933.7933 )
- Hex:3 HexNAc:5 (avg mass : 1520.4175 )
- Hex:1 HexNAc:2 dHex:1 (avg mass : 732.6907 )
- Hex:5 HexNAc:6 dHex:3 (avg mass : 2486.3263 )
- Hex:5 HexNAc:4 NeuGc:2 (avg mass : 2256.0219 )
- Hex:4 HexNAc:5 NeuGc:2
- Hex:3 HexNAc:5 (avg mass : 1520.4175 )
- Hex:1 HexNAc:2 dHex:1 (avg mass : 732.6907 )
- Hex:5 HexNAc:4 dHex:2 NeuAc:1 (avg mass : 2225.0512 )
- Hex:5 HexNAc:5 dHex:1 NeuAc:1 (avg mass : 2282.1032 )
- Hex:7 HexNAc:4 NeuAc:1 (avg mass : 2257.05 )
- Hex:6 HexNAc:5 NeuGc:1 (avg mass : 2314.102 )
- Hex:6 HexNAc:6 NeuAc:1 NeuGc:1
- Hex:6 HexNAc:5 (avg mass : 2006.8447 )
- Hex:5 HexNAc:4 NeuAc:1 NeuGc:1 (avg mass : 2240.0225 )
- Hex:4 HexNAc:5 NeuAc:1 NeuGc:1
- Hex:8 HexNAc:2 (avg mass : 1721.5445 )
- Hex:7 HexNAc:4 (avg mass : 1965.7921 )
- Hex:5 HexNAc:4 NeuAc:1 (avg mass : 1932.7652 )
- Hex:6 HexNAc:4 dHex:3 (avg mass : 2242.0787 )
- Hex:5 HexNAc:6 dHex:1 NeuAc:1 (avg mass : 2485.2982 )
- Hex:5 HexNAc:5 dHex:3 (avg mass : 2283.1313 )
- Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )
- Hex:5 HexNAc:4 (avg mass : 1641.5073 )
- Hex:6 HexNAc:5 dHex:2 (avg mass : 2299.1307 )
- Hex:5 HexNAc:5 dHex:3 (avg mass : 2283.1313 )
- Hex:6 HexNAc:4 dHex:1 (avg mass : 1949.7927 )
- Hex:5 HexNAc:6 dHex:2 (avg mass : 2340.1833 )

Protein and gene references

UniProtKB : P02760

neXtProt : NX_P02760

GeneCards : AMBP

3D structure from PDB

Select a PDB entry

Github Wiki

3D visualization by LiteMol

References (4)

Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018)
Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang
Pubmed : 29741879 DOI : 10.1021/acs.analchem.8b01137
Status : Unreviewed

Distinct urinary glycoprotein signatures in prostate cancer patients (2018)
Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano
Pubmed : 30237853 DOI : 10.18632/oncotarget.26005
Status : Unreviewed

Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD (2012)
Halim A, Nilsson J, Rüetschi U, Hesse C, Larson G
Pubmed : 22171320 DOI : 10.1074/mcp.M111.013649
Status : Reviewed

Location and characterization of the three carbohydrate prosthetic groups of human protein HC. (1990)
Escribano J, Lopex-Otin C, Hjerpe A, Grubb A, Mendez E
Pubmed : 1694784
Status : Reviewed