GlyConnect

Taxonomy (1) Protein (1) Source (1) Structure (0) Composition (11) Disease (1) Site (1) Peptide (1)

Taxonomy

Homo sapiens (Human)

Protein

Type 2 lactosamine alpha-2,3-sialyltransferase / Homo sapiens Q9Y274

Source

Mammary Gland (UBERON_0001911)

Reported structure

Composition

Disease

Cancer, breast (DOID:1612)

Reported glycosite

Type 2 lactosamine alpha-2,3-sialyltransferase / Homo sapiens :
- Asn-308

Mass spectrometry validated peptide

NVTAEQLFLK (10aa)
- Q9Y274 Asn-308

- Hex:6 HexNAc:3 dHex:1 (avg mass : 1746.5977 )
- Hex:5 HexNAc:6 dHex:1 NeuAc:1 (avg mass : 2485.2982 )
- Hex:4 HexNAc:6 NeuAc:1 (avg mass : 2177.0128 )
- Hex:6 HexNAc:5 dHex:4 (avg mass : 2591.4167 )
- Hex:6 HexNAc:5 NeuAc:2 (avg mass : 2589.3605 )
- Hex:6 HexNAc:3 dHex:2
- Hex:5 HexNAc:5 dHex:1 NeuAc:1 (avg mass : 2282.1032 )
- Hex:6 HexNAc:4 dHex:2 (avg mass : 2095.9357 )
- Hex:8 HexNAc:2 (avg mass : 1721.5445 )
- Hex:4 HexNAc:6 dHex:1 (avg mass : 2031.8979 )
- Hex:6 HexNAc:5 dHex:2 NeuAc:1 (avg mass : 2590.3886 )

Protein and gene references

UniProtKB : Q9Y274

neXtProt : NX_Q9Y274

GeneCards : ST3GAL6

3D structure from PDB

Either no PDB or existing PDB of non-glycosylated form

References (1)

Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018)
Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang
Pubmed : 29741879 DOI : 10.1021/acs.analchem.8b01137
Status : Unreviewed