Receptor tyrosine-protein kinase erbB-2

Taxonomy

• Homo sapiens (Human)

Protein

• Receptor tyrosine-protein kinase erbB-2 / Homo sapiens    P04626

Source

• Mammary Gland (UBERON_0001911)  
• Urine (UBERON_0001088)  

Reported structure

Composition

• Hex:3 HexNAc:4 NeuAc:2 (avg mass : 1899.7383 )
• Hex:4 HexNAc:4 dHex:2 NeuAc:1 (avg mass : 2062.9088 )
• Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )
• Hex:5 HexNAc:4 dHex:2 (avg mass : 1933.7933 )
• Hex:6 HexNAc:2 (avg mass : 1397.2597 )
• Hex:6 HexNAc:5 dHex:1 NeuAc:3 (avg mass : 3026.7614 )
• Hex:6 HexNAc:5 dHex:2 (avg mass : 2299.1307 )
• Hex:6 HexNAc:5 dHex:3 (avg mass : 2445.2737 )
• Hex:6 HexNAc:5 dHex:4 (avg mass : 2591.4167 )
• Hex:7 HexNAc:2 (avg mass : 1559.4021 )
• Hex:7 HexNAc:6 dHex:5 (avg mass : 3102.8971 )
• Hex:8 HexNAc:2 (avg mass : 1721.5445 )
• Hex:9 HexNAc:2 (avg mass : 1883.6869 )
• Hex:12 HexNAc:2 (avg mass : 2370.1141 )

Disease

• Cancer, breast (DOID:1612)
• Prostate cancer (DOID:10283)

Reference

• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed

Reported glycosite

• Receptor tyrosine-protein kinase erbB-2 / Homo sapiens
  •        Asn-124
  •        Asn-187
  •        Asn-259
  •        Asn-530
  •        Asn-629
  •        Ser-998

Mass spectrometry observed peptide

• GTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLR (35aa)
  •    P04626    Asn-124     Receptor tyrosine-protein kinase erbB-2 / Homo sapiens
• NNQLALTLIDTNR (13aa)
  •    P04626    Asn-187     Receptor tyrosine-protein kinase erbB-2 / Homo sapiens
• HSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGR (40aa)
  •    P04626    Asn-259     Receptor tyrosine-protein kinase erbB-2 / Homo sapiens
• GHCWGPGPTQCVNCSQFLR (19aa)
  •    P04626    Asn-530     Receptor tyrosine-protein kinase erbB-2 / Homo sapiens
• GPTQCVNCSQFIR (13aa)
  •    P04626    Asn-530     Receptor tyrosine-protein kinase erbB-2 / Homo sapiens
• FPDEEGACQPCPINCTHSCVDLDDK (25aa)
  •    P04626    Asn-629     Receptor tyrosine-protein kinase erbB-2 / Homo sapiens
• DPQRFVVIQNEDLGPASPLDSTFYR (25aa)
  •    P04626    Ser-998     Receptor tyrosine-protein kinase erbB-2 / Homo sapiens