BRCA2-interacting transcriptional repressor EMSY

Taxonomy

• Homo sapiens (Human)

Protein

• BRCA2-interacting transcriptional repressor EMSY / Homo sapiens    Q7Z589

Source

• Mammary Gland (UBERON_0001911)  
• HeLa (CVCL_0030)  

Reported structure

• O-Linked / O-GlcNAc / GlcNAc(b

Composition

• HexNAc:1 (avg mass : 221.2103 )
• Hex:6 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2241.0506 )
• Hex:6 HexNAc:6 dHex:1 (avg mass : 2356.1827 )

Disease

• Cancer, breast (DOID:1612)

Reference

• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Extensive Crosstalk Between O-GlcNAcylation and Phosphorylation Regulates Cytokinesis (2010 - Zihao Wang, Namrata D Udeshi, Chad Slawson, Philip D Compton, Kaoru Sakabe, Win D Cheung, Jeffrey Shabanowitz, Donald F Hunt, Gerald W Hart) / Status : Reviewed

Reported glycosite

• BRCA2-interacting transcriptional repressor EMSY / Homo sapiens
  •        Ser-228
  •        Ser-236
  •        Thr-271
  •        Thr-501
  •        Thr-506
  •        Thr-534
  •        Thr-535
  •        Ser-557
  •        Thr-1120
  •        Asn-1199

Mass spectrometry observed peptide

• AVVPVSK (7aa)
  •    Q7Z589    Ser-228     BRCA2-interacting transcriptional repressor EMSY / Homo sapiens
• TITVPVSGSPK (11aa)
  •    Q7Z589    Ser-236     BRCA2-interacting transcriptional repressor EMSY / Homo sapiens
• PSTQTTNTTTQK (12aa)
  •    Q7Z589    Thr-271     BRCA2-interacting transcriptional repressor EMSY / Homo sapiens
• LVTTPTGTQATYTRPTVSPSIGR (23aa)
  •    Q7Z589    Thr-501     BRCA2-interacting transcriptional repressor EMSY / Homo sapiens
  •    Q7Z589    Thr-506     BRCA2-interacting transcriptional repressor EMSY / Homo sapiens
• TTSGSIITVVPK (12aa)
  •    Q7Z589    Thr-535     BRCA2-interacting transcriptional repressor EMSY / Homo sapiens
  •    Q7Z589    Thr-534     BRCA2-interacting transcriptional repressor EMSY / Homo sapiens
• IISSNIVSGTTTK (13aa)
  •    Q7Z589    Ser-557     BRCA2-interacting transcriptional repressor EMSY / Homo sapiens
• ITGGSSVPK (9aa)
  •    Q7Z589    Thr-1120     BRCA2-interacting transcriptional repressor EMSY / Homo sapiens
• NSTPQQQK (8aa)
  •    Q7Z589    Asn-1199     BRCA2-interacting transcriptional repressor EMSY / Homo sapiens