Legumain

Taxonomy

• Homo sapiens (Human)

Protein

• Legumain / Homo sapiens    Q99538

Source

• Mammary Gland (UBERON_0001911)  
• Milk (UBERON_0001913)  

Reported structure

• N-Linked / High-Mannose / Man(a1-3)[Man(a1-6)]Man(a1-6)[Man(a1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

• Hex:3 HexNAc:2 (avg mass : 910.8325 )
• Hex:3 HexNAc:6 dHex:1 NeuAc:2 (avg mass : 2452.2713 )
• Hex:5 HexNAc:2 (avg mass : 1235.1173 )
• Hex:6 HexNAc:2 (avg mass : 1397.2597 )
• Hex:7 HexNAc:2 (avg mass : 1559.4021 )

Disease

• Cancer, breast (DOID:1612)

Reference

• Quantitative Longitudinal Inventory of the N-Glycoproteome of Human Milk from a Single Donor Reveals the Highly Variable Repertoire and Dynamic Site-Specific Changes (2020 - Jing Zhu, Yu-Hsien Lin, Kelly A Dingess, Marko Mank, Bernd Stahl, Albert J R Heck) / Status : Reviewed
• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed

Reported glycosite

• Legumain / Homo sapiens
  •        Asn-167
  •        Asn-263

Mass spectrometry observed peptide

• KDLNETIHYMYKH (13aa)
  •    Q99538    Asn-167     Legumain / Homo sapiens
• DINETIHYMYK (11aa)
  •    Q99538    Asn-167     Legumain / Homo sapiens
• SHTNTSHVMQYGNK (14aa)
  •    Q99538    Asn-263     Legumain / Homo sapiens