GlyConnect

Taxonomy (1) Protein (1) Source (1) Structure (0) Composition (18) Disease (1) Site (2) Peptide (2)

Taxonomy

Homo sapiens (Human)

Protein

Lactadherin / Homo sapiens Q08431

Source

Mammary Gland (UBERON_0001911)

Reported structure

Composition

Disease

Cancer, breast (DOID:1612)

Reported glycosite

Lactadherin / Homo sapiens :
- Asn-238
- Asn-325

Mass spectrometry validated peptide

NNSIPDK (7aa)
- Q08431 Asn-238
VAYSNDSANWTEYQDPR (17aa)
- Q08431 Asn-325

- Hex:4 HexNAc:6 dHex:1 (avg mass : 2031.8979 )
- Hex:5 HexNAc:4 dHex:2 NeuAc:1 (avg mass : 2225.0512 )
- Hex:6 HexNAc:3 (avg mass : 1600.4547 )
- Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )
- Hex:12 HexNAc:2 (avg mass : 2370.1141 )
- Hex:5 HexNAc:4 dHex:3 (avg mass : 2079.9363 )
- Hex:5 HexNAc:4 dHex:4
- Hex:8 HexNAc:2 (avg mass : 1721.5445 )
- Hex:6 HexNAc:2 (avg mass : 1397.2597 )
- Hex:6 HexNAc:3 NeuAc:1 (avg mass : 1891.7126 )
- Hex:6 HexNAc:3 dHex:1 NeuAc:1 (avg mass : 2037.8556 )
- Hex:5 HexNAc:2 (avg mass : 1235.1173 )
- Hex:9 HexNAc:2 (avg mass : 1883.6869 )
- Hex:6 HexNAc:3 dHex:2
- Hex:3 HexNAc:6 (avg mass : 1723.6125 )
- Hex:5 HexNAc:3 NeuAc:1 (avg mass : 1729.5702 )
- Hex:7 HexNAc:2 (avg mass : 1559.4021 )
- Hex:4 HexNAc:6 (avg mass : 1885.7549 )

Protein and gene references

UniProtKB : Q08431

neXtProt : NX_Q08431

GeneCards : MFGE8

3D structure from PDB

Either no PDB or existing PDB of non-glycosylated form

References (1)

Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018)
Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang
Pubmed : 29741879 DOI : 10.1021/acs.analchem.8b01137
Status : Unreviewed