GlyConnect

Taxonomy (1) Protein (1) Source (4) Structure (52) Composition (50) Disease (3) Site (11) Peptide (10)

Taxonomy

Homo sapiens (Human)

Protein

Epidermal growth factor receptor / Homo sapiens P00533

Source

Reported structure

Composition

Disease

Reported glycosite

Epidermal growth factor receptor / Homo sapiens :
- Undefined site
- Asn-56
- Asn-175
- Asn-196
- Asn-271
- Asn-352
- Asn-361
- Asn-413
- Asn-468
- Asn-603
- Asn-816

Mass spectrometry validated peptide

MFNNCEVVLGNLEITYVQR (19aa)
- P00533 Asn-56
DIVSSDFLSNMSMDFQNHLGSCQK (24aa)
- P00533 Asn-175
CDPSCPNGSCWGAGEENCQK (20aa)
- P00533 Asn-196
DTCPPLMLYNPTTYQMDVNPEGK (23aa)
- P00533 Asn-271
DSISINATNIK (11aa)
- P00533 Asn-352
NCTSISGDLHILPVAFR (17aa)
- P00533 Asn-361
EITGFLLIQAWPENR (15aa)
- P00533 Asn-413
NLCYANTINWK (11aa)
- P00533 Asn-468
TCPAGVMGENNTLVWK (16aa)
- P00533 Asn-603
DNIGSQYLLNWCVQIAK (17aa)
- P00533 Asn-816

- N-Linked / Complex (avg mass : 2516.3091 )
- N-Linked / Complex (avg mass : 2574.3892 )
- N-Linked / Complex (avg mass : 2428.2462 )
- N-Linked / Complex (avg mass : 3683.3567 )
- N-Linked / Complex
- N-Linked / Complex (avg mass : 2371.1942 )
- N-Linked / Complex (avg mass : 4048.6941 )
- N-Linked / Complex (avg mass : 2225.0512 )
- N-Linked / Complex (avg mass : 2428.2462 )
- N-Linked / Complex (avg mass : 2136.9883 )
- N-Linked / Complex (avg mass : 2152.9877 )
- N-Linked / Complex (avg mass : 2516.3091 )
- N-Linked / Complex (avg mass : 2371.1942 )
- N-Linked / Complex (avg mass : 2370.1661 )
- N-Linked / Complex (avg mass : 2136.9883 )
- N-Linked / High-Mannose (avg mass : 1235.1173 )
- N-Linked / Complex (avg mass : 1932.7652 )
- N-Linked / Complex (avg mass : 2282.1032 )
- N-Linked / Complex (avg mass : 3829.4997 )
- N-Linked / Complex (avg mass : 2283.1313 )
- N-Linked / Complex (avg mass : 3829.4997 )
- N-Linked / Complex (avg mass : 2078.9082 )
- N-Linked / Complex (avg mass : 2486.3263 )
- N-Linked / Complex (avg mass : 2340.1833 )
- N-Linked / Complex (avg mass : 2078.9082 )
- N-Linked / High-Mannose (avg mass : 1721.5445 )
- N-Linked / Complex (avg mass : 2079.9363 )
- N-Linked / Complex (avg mass : 2502.3257 )
- N-Linked / Complex (avg mass : 2178.0409 )
- N-Linked / Complex (avg mass : 2502.3257 )
- N-Linked / High-Mannose (avg mass : 1397.2597 )
- N-Linked / Complex (avg mass : 4340.9801 )
- N-Linked / Complex (avg mass : 2078.9082 )
- N-Linked / Complex (avg mass : 2225.0512 )
- N-Linked / Complex (avg mass : 2299.1307 )
- N-Linked / Complex (avg mass : 2356.1827 )
- N-Linked / Complex (avg mass : 2006.8447 )
- N-Linked / Complex (avg mass : 2282.1032 )
- N-Linked / Complex (avg mass : 2224.0231 )
- N-Linked / Complex (avg mass : 2136.9883 )
- N-Linked / Complex (avg mass : 4048.6941 )
- N-Linked / High-Mannose (avg mass : 1559.4021 )
- N-Linked / Complex
- N-Linked / Complex (avg mass : 2152.9877 )
- N-Linked / Complex (avg mass : 2225.0512 )
- N-Linked / Complex (avg mass : 2356.1827 )
- N-Linked / Complex (avg mass : 2283.1313 )
- N-Linked / Complex (avg mass : 2152.9877 )
- N-Linked / High-Mannose (avg mass : 1559.4021 )
- N-Linked / Complex (avg mass : 2299.1307 )
- N-Linked / Complex (avg mass : 1787.6503 )
- N-Linked / Complex (avg mass : 2078.9082 )

- Hex:6 HexNAc:5 NeuAc:1 (avg mass : 2298.1026 )
- Hex:4 HexNAc:3 NeuAc:1 (avg mass : 1567.4278 )
- Hex:7 HexNAc:2 (avg mass : 1559.4021 )
- Hex:5 HexNAc:2 (avg mass : 1235.1173 )
- Hex:6 HexNAc:6 dHex:1 NeuAc:2 (avg mass : 2938.6985 )
- Hex:6 HexNAc:4 dHex:3 (avg mass : 2242.0787 )
- Hex:6 HexNAc:5 dHex:1 NeuAc:3 (avg mass : 3026.7614 )
- Hex:3 HexNAc:4 dHex:1 (avg mass : 1463.3655 )
- Hex:5 HexNAc:4 dHex:1 NeuAc:2 (avg mass : 2370.1661 )
- Hex:5 HexNAc:4 dHex:2 NeuAc:1 (avg mass : 2225.0512 )
- Hex:9 HexNAc:2 (avg mass : 1883.6869 )
- Hex:4 HexNAc:4 dHex:1 (avg mass : 1625.5079 )
- Hex:6 HexNAc:2 (avg mass : 1397.2597 )
- Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )
- Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )
- Hex:5 HexNAc:5 NeuAc:1 (avg mass : 2135.9602 )
- Hex:6 HexNAc:5 dHex:1 NeuAc:2 (avg mass : 2735.5035 )
- Hex:6 HexNAc:6 (avg mass : 2210.0397 )
- Hex:5 HexNAc:4 dHex:3 (avg mass : 2079.9363 )
- Hex:7 HexNAc:6 NeuAc:3 (avg mass : 3245.9558 )
- Hex:6 HexNAc:5 NeuAc:3 (avg mass : 2880.6184 )
- Hex:8 HexNAc:2 (avg mass : 1721.5445 )
- Hex:6 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2241.0506 )
- Hex:6 HexNAc:5 dHex:2 NeuAc:2 (avg mass : 2881.6465 )
- Hex:6 HexNAc:5 NeuAc:2 (avg mass : 2589.3605 )
- Hex:12 HexNAc:2 (avg mass : 2370.1141 )
- Hex:6 HexNAc:5 dHex:1 NeuAc:1 (avg mass : 2444.2456 )
- Hex:7 HexNAc:6 NeuAc:2 (avg mass : 2954.6979 )
- Hex:5 HexNAc:4 NeuAc:1 (avg mass : 1932.7652 )

Protein and gene references

UniProtKB : P00533

neXtProt : NX_P00533

GeneCards : EGFR

3D structure from PDB

Select a PDB entry

Github Wiki

3D visualization by LiteMol

References (4)

Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018)
Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang
Pubmed : 29741879 DOI : 10.1021/acs.analchem.8b01137
Status : Unreviewed

Large-scale intact glycopeptide identification by Mascot database search (2018)
Ravi Chand Bollineni, Christian Jeffrey Koehler, Randi Elin Gislefoss, Jan Haug Anonsen, Bernd Thiede
Pubmed : 29391424 DOI : 10.1038/s41598-018-20331-2
Status : Unreviewed

Characterization of the carbohydrate chains of the secreted form of the human epidermal growth factor receptor. (2000)
Stroop C, Weber W, Gerwig G, Nimtz M, Kamerling J, Vliegenthart J
Pubmed : 10988252
Status : Reviewed

Characterisation of the N-oligosaccharides attached to the atypical Asn-X-Cys sequence of recombinant human epidermal growth factor receptor (2000)
Sato, Kim, Abe, Saito, Yokoyama, Kohda
Pubmed : 10731668
Status : Reviewed