Hepatocyte growth factor activator

Taxonomy

• Homo sapiens (Human)

Protein

• Hepatocyte growth factor activator / Homo sapiens    Q04756

Source

• Blood Serum (UBERON_0001977)  
• Mammary Gland (UBERON_0001911)  

Reported structure

Composition

• Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:1 (avg mass : 2078.9082 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:2 (avg mass : 2370.1661 )
• Hex:5 HexNAc:4 dHex:2 NeuAc:1 (avg mass : 2225.0512 )
• Hex:5 HexNAc:4 dHex:2 NeuAc:2 (avg mass : 2516.3091 )
• Hex:6 HexNAc:4 NeuAc:1 (avg mass : 2094.9076 )
• Hex:6 HexNAc:4 dHex:2 NeuAc:1 (avg mass : 2387.1936 )
• Hex:6 HexNAc:5 NeuAc:2 (avg mass : 2589.3605 )
• Hex:6 HexNAc:5 dHex:1 NeuAc:2 (avg mass : 2735.5035 )
• Hex:6 HexNAc:5 dHex:1 NeuAc:3 (avg mass : 3026.7614 )
• Hex:6 HexNAc:5 dHex:2 NeuAc:3 (avg mass : 3172.9044 )
• Hex:6 HexNAc:5 dHex:3 NeuAc:1 (avg mass : 2736.5316 )
• Hex:6 HexNAc:5 dHex:3 NeuAc:2 (avg mass : 3027.7895 )

Disease

• Cancer, breast (DOID:1612)
• Prostate cancer (DOID:10283)

Reference

• Site-Specific Profiling of Serum Glycoproteins Using N-Linked Glycan and Glycosite Analysis Revealing Atypical N-Glycosylation Sites on Albumin and α-1B-Glycoprotein (2018 - Shisheng Sun, Yingwei Hu, Li Jia, Shadi Toghi Eshghi, Yang Liu, Punit Shah, Hui Zhang) / Status : Unreviewed
• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Large-scale intact glycopeptide identification by Mascot database search (2018 - Ravi Chand Bollineni, Christian Jeffrey Koehler, Randi Elin Gislefoss, Jan Haug Anonsen, Bernd Thiede) / Status : Unreviewed

Reported glycosite

• Hepatocyte growth factor activator / Homo sapiens
  •        Asn-290
  •        Asn-468
  •        Asn-492
  •        Asn-546

Mass spectrometry observed peptide

• CFLGNGTGYR (10aa)
  •    Q04756    Asn-290     Hepatocyte growth factor activator / Homo sapiens
• DSVSVVLGQHFFNR (14aa)
  •    Q04756    Asn-468     Hepatocyte growth factor activator / Homo sapiens
• DSVSVVIGQHFFNR (14aa)
  •    Q04756    Asn-468     Hepatocyte growth factor activator / Homo sapiens
• YIPYTLYSVFNPSDHDLVLIR (21aa)
  •    Q04756    Asn-492     Hepatocyte growth factor activator / Homo sapiens
• CQIAGWGHLDENVSGYSSSLR (21aa)
  •    Q04756    Asn-546     Hepatocyte growth factor activator / Homo sapiens