Extracellular sulfatase Sulf-2

Taxonomy

• Homo sapiens (Human)

Protein

• Extracellular sulfatase Sulf-2 / Homo sapiens    Q8IWU5

Source

• Mammary Gland (UBERON_0001911)  
• Urine (UBERON_0001088)  

Reported structure

Composition

• Hex:5 HexNAc:2 (avg mass : 1235.1173 )
• Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )
• Hex:6 HexNAc:5 NeuAc:2 (avg mass : 2589.3605 )
• Hex:8 HexNAc:2 (avg mass : 1721.5445 )
• Hex:9 HexNAc:2 (avg mass : 1883.6869 )

Disease

• Cancer, breast (DOID:1612)
• Prostate cancer (DOID:10283)

Reference

• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed

Reported glycosite

• Extracellular sulfatase Sulf-2 / Homo sapiens
  •        Asn-112
  •        Asn-132
  •        Asn-149
  •        Asn-198

Mass spectrometry observed peptide

• YVHNHNTYTNNENCSSPSWQAQHESR (26aa)
  •    Q8IWU5    Asn-112
• TFAVYINSTGYR (12aa)
  •    Q8IWU5    Asn-132
• YLNEYNGSYVPPGWKEWVGLLK (22aa)
  •    Q8IWU5    Asn-149
• DYLTDLITNDSVSFFR (16aa)
  •    Q8IWU5    Asn-198