Epididymis-specific alpha-mannosidase

Taxonomy

• Homo sapiens (Human)

Protein

• Epididymis-specific alpha-mannosidase / Homo sapiens    Q9Y2E5

Source

• Blood Serum (UBERON_0001977)  
• Mammary Gland (UBERON_0001911)  

Reported structure

Composition

• Hex:3 HexNAc:2 (avg mass : 910.8325 )
• Hex:4 HexNAc:3 NeuAc:1 (avg mass : 1567.4278 )
• Hex:4 HexNAc:4 NeuAc:1 (avg mass : 1770.6228 )
• Hex:5 HexNAc:3 NeuAc:1 (avg mass : 1729.5702 )
• Hex:5 HexNAc:4 NeuAc:1 (avg mass : 1932.7652 )
• Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )
• Hex:5 HexNAc:4 dHex:1 NeuAc:2 (avg mass : 2370.1661 )
• Hex:6 HexNAc:2 (avg mass : 1397.2597 )
• Hex:6 HexNAc:5 NeuAc:2 (avg mass : 2589.3605 )
• Hex:6 HexNAc:5 dHex:2 NeuAc:2 (avg mass : 2881.6465 )

Disease

• Cancer, breast (DOID:1612)
• Prostate cancer (DOID:10283)

Reference

• Large-scale intact glycopeptide identification by Mascot database search (2018 - Ravi Chand Bollineni, Christian Jeffrey Koehler, Randi Elin Gislefoss, Jan Haug Anonsen, Bernd Thiede) / Status : Unreviewed
• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed

Reported glycosite

• Epididymis-specific alpha-mannosidase / Homo sapiens
  •        Asn-336
  •        Asn-516
  •        Asn-748

Mass spectrometry observed peptide

• AIHAINVTWR (10aa)
  •    Q9Y2E5    Asn-336
• ALHALNVTWR (10aa)
  •    Q9Y2E5    Asn-336
• VTDEAGHPVPSQIQNSTETPSAYDIIIITTIPGISYR (37aa)
  •    Q9Y2E5    Asn-516
• RPYVSYVNNSIAR (13aa)
  •    Q9Y2E5    Asn-748