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  • E3 ubiquitin-protein ligase HERC2

E3 ubiquitin-protein ligase HERC2

Taxonomy : Homo sapiens

SNFG, Text, Oxford
Taxonomy (1) Protein (1) Source (2) Structure (0) Composition (2) Disease (1) Site (2) Peptide (2)

    Taxonomy

  • Homo sapiens (Human)

    Protein

  • E3 ubiquitin-protein ligase HERC2 / Homo sapiens    O95714

    Source

  • Blood Serum (UBERON_0001977)  
  • Mammary Gland (UBERON_0001911)  

    Reported structure

    Composition

  • Hex:5 HexNAc:4 NeuAc:1 (avg mass : 1932.7652 )
  • Hex:6 HexNAc:2 (avg mass : 1397.2597 )

    Disease

  • Cancer, breast (DOID:1612)

    Reported glycosite

  • E3 ubiquitin-protein ligase HERC2 / Homo sapiens :
    •        Asn-2790
    •        Asn-3746

    Mass spectrometry validated peptide

  • SLNVSSSVNQASR (13aa)
    •    O95714    Asn-2790
  • LNLASNR (7aa)
    •    O95714    Asn-3746
  • 5 x 4 x 1 x
    • Hex:5 HexNAc:4 NeuAc:1 (avg mass : 1932.7652 )
    • Site (1) Suggested Structure (0)

        Suggested structure

        Reported glycosite

      • E3 ubiquitin-protein ligase HERC2 / Homo sapiens :
        •        Asn-2790
  • 6 x 2 x
    • Hex:6 HexNAc:2 (avg mass : 1397.2597 )
    • Site (1) Suggested Structure (0)

        Suggested structure

        Reported glycosite

      • E3 ubiquitin-protein ligase HERC2 / Homo sapiens :
        •        Asn-3746

Protein and gene references

UniProtKB : O95714

neXtProt : NX_O95714

GeneCards : HERC2

3D structure from PDB

Either no PDB or existing PDB of non-glycosylated form

References (2)

Site-Specific Profiling of Serum Glycoproteins Using N-Linked Glycan and Glycosite Analysis Revealing Atypical N-Glycosylation Sites on Albumin and α-1B-Glycoprotein (2018)
Shisheng Sun, Yingwei Hu, Li Jia, Shadi Toghi Eshghi, Yang Liu, Punit Shah, Hui Zhang
Pubmed : 29671580   DOI : 10.1021/acs.analchem.8b01051
Status : Unreviewed

Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018)
Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang
Pubmed : 29741879   DOI : 10.1021/acs.analchem.8b01137
Status : Unreviewed

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