Pro-opiomelanocortin

Taxonomy

• Mus musculus (House mouse)

Protein

• Pro-opiomelanocortin / Mus musculus    P01193

Source

• Brain (UBERON_0000955)  
• Pituitary Gland (UBERON_0000007)   AtT-20 (CVCL_2300)  

Reported structure

• N-Linked / Complex / HSO3(-4)GalNAc(b1-4)GlcNAc(b1-2)Man(a1-?)[GalNAc(b1-4)GlcNAc(b1-2)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / HSO3(-4)GalNAc(b1-4)GlcNAc(b1-2)Man(a1-3)[HSO3(-4)GalNAc(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / HSO3(-4)GalNAc(b1-4)GlcNAc(b1-2)Man(a1-?)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-2)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

• Hex:3 HexNAc:6 (avg mass : 1723.6125 )
• Hex:3 HexNAc:6 Su:1 (avg mass : 1803.6767 )
• Hex:3 HexNAc:6 Su:2 (avg mass : 1883.7409 )
• Hex:4 HexNAc:5 NeuAc:1 Su:1 (avg mass : 2053.882 )
• Hex:8 HexNAc:2 (avg mass : 1721.5445 )

Disease

• Tumor, Pituitary (DOID:1785)

Reference

• Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis (2019 - Nicholas M. Riley, Alexander S. Hebert, Michael S. Westphall & Joshua J. Coon ) / Status : Unreviewed
• Pro-opiomelanocortin synthesized by corticotrophs bears asparagine-linked oligosaccharides terminating with SO4-4GalNAc beta 1,4GlcNAc beta 1,2Man alpha. (1992 - Skelton T, Kumar S, Smith P, Beranek M, Baenziger J) / Status : Reviewed

Reported glycosite

• Pro-opiomelanocortin / Mus musculus
  •        Undefined site
  •        Asn-152

Mass spectrometry observed peptide

• VYPNVAENESAEAFPLEFK (19aa)
  •    P01193    Asn-152