GlyConnect

Taxonomy (1) Protein (1) Source (1) Structure (0) Composition (20) Disease (1) Site (2) Peptide (2)

Taxonomy

Homo sapiens (Human)

Protein

Cation-dependent mannose-6-phosphate receptor / Homo sapiens P20645

Source

Mammary Gland (UBERON_0001911)

Reported structure

Composition

Disease

Cancer, breast (DOID:1612)

Reported glycosite

Cation-dependent mannose-6-phosphate receptor / Homo sapiens :
- Asn-57
- Asn-83

Mass spectrometry validated peptide

LKPLFNK (7aa)
- P20645 Asn-57
EAGNHTSGAGIVQINK (16aa)
- P20645 Asn-83

- Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )
- Hex:6 HexNAc:3 dHex:3
- Hex:7 HexNAc:2 (avg mass : 1559.4021 )
- Hex:6 HexNAc:5 dHex:4 (avg mass : 2591.4167 )
- Hex:8 HexNAc:2 (avg mass : 1721.5445 )
- Hex:6 HexNAc:5 dHex:1 (avg mass : 2152.9877 )
- Hex:6 HexNAc:3 (avg mass : 1600.4547 )
- Hex:12 HexNAc:2 (avg mass : 2370.1141 )
- Hex:6 HexNAc:3 dHex:2
- Hex:6 HexNAc:5 dHex:2 (avg mass : 2299.1307 )
- Hex:6 HexNAc:3 dHex:1 NeuAc:1 (avg mass : 2037.8556 )
- Hex:6 HexNAc:5 dHex:3 (avg mass : 2445.2737 )
- Hex:5 HexNAc:2 dHex:1 (avg mass : 1381.2603 )
- Hex:5 HexNAc:4 dHex:2 NeuAc:1 (avg mass : 2225.0512 )
- Hex:5 HexNAc:2 (avg mass : 1235.1173 )
- Hex:6 HexNAc:5 dHex:3 NeuAc:1
- Hex:6 HexNAc:2 (avg mass : 1397.2597 )
- Hex:8 HexNAc:7 dHex:1 (avg mass : 2883.6625 )
- Hex:6 HexNAc:3 NeuAc:1 (avg mass : 1891.7126 )
- Hex:6 HexNAc:5 dHex:7

Protein and gene references

UniProtKB : P20645

neXtProt : NX_P20645

GeneCards : M6PR

3D structure from PDB

Either no PDB or existing PDB of non-glycosylated form

References (1)

Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018)
Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang
Pubmed : 29741879 DOI : 10.1021/acs.analchem.8b01137
Status : Unreviewed